Ly6C+ monocytes in the skin promote systemic alphavirus dissemination

• Published in: Cell reports (Cambridge) Vol. 43; no. 3; p. 113876
• Main Authors: Holmes, Autumn C., Lucas, Cormac J., Brisse, Morgan E., Ware, Brian C., Hickman, Heather D., Morrison, Thomas E., Diamond, Michael S.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 26.03.2024; Elsevier
• Subjects: alphavirus; Animals; Chikungunya Fever - pathology; Chikungunya virus; CP: Immunology; CP: Microbiology; dissemination; immunity; lymph node; monocytes; Monocytes - pathology; Mosquito Vectors; mouse models; Myeloid Cells; pathogenesis; viremia; Virus Replication; mouse models; CP: Immunology; pathogenesis; monocytes; dissemination; lymph node; CP: Microbiology; alphavirus; immunity; viremia

Alphaviruses are mosquito-transmitted pathogens that induce high levels of viremia, which facilitates dissemination and vector transmission. One prevailing paradigm is that, after skin inoculation, alphavirus-infected resident dendritic cells migrate to the draining lymph node (DLN), facilitating fu...