Gold Nanorod Assisted Enhanced Plasmonic Detection Scheme of COVID‐19 SARS‐CoV‐2 Spike Protein

The beautiful interplay between light and matter can give rise to many striking physical phenomena, surface plasmon resonance (SPR) being one of them. Plasmonic immunosensors monitor refractive index changes that occur as a result of specific ligand–analyte or antibody–antigen interactions taking pl...

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Published inAdvanced theory and simulations Vol. 3; no. 11; pp. 2000185 - n/a
Main Authors Das, Chandreyee Manas, Guo, Yan, Yang, Guang, Kang, Lixing, Xu, Gaixia, Ho, Ho‐Pui, Yong, Ken‐Tye
Format Journal Article
LanguageEnglish
Published Hoboken John Wiley and Sons Inc 01.11.2020
Subjects
COVID‐19
gold nanorods
kretschmann layouts
plasmonic immunosensors
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Abstract The beautiful interplay between light and matter can give rise to many striking physical phenomena, surface plasmon resonance (SPR) being one of them. Plasmonic immunosensors monitor refractive index changes that occur as a result of specific ligand–analyte or antibody–antigen interactions taking place on the sensor surface. The coronavirus disease (COVID‐19) pandemic has jeopardized the entire world and has resulted in economic slowdown of most countries. In this work, a model of a sandwich plasmonic biosensor that utilizes gold nanorods (Au NRs) for the detection of COVID‐19 SARS‐CoV‐2 spike protein is presented. Simulation results for different prismatic configurations for the basic Kretschmann layout are presented. It is found that a BK7 glass prism‐based SPR sensor has an incremental sensitivity of 111.11 deg RIU−1. Additionally, using Comsol Multiphysics the electric field enhancement observed for various aspect ratios and layouts of Au NRs are discussed in depth. The coronavirus disease (COVID‐19) pandemic has adversely affected the entire world, where apart from stressing the medical fraternity, it has resulted in a major economic slowdown. In this paper, a unique detection scheme for quantifying SARS‐CoV‐2 virus using a plasmonic immunosensor that uses gold nanorods for signal amplification is presented.
AbstractList The beautiful interplay between light and matter can give rise to many striking physical phenomena, surface plasmon resonance (SPR) being one of them. Plasmonic immunosensors monitor refractive index changes that occur as a result of specific ligand-analyte or antibody-antigen interactions taking place on the sensor surface. The coronavirus disease (COVID-19) pandemic has jeopardized the entire world and has resulted in economic slowdown of most countries. In this work, a model of a sandwich plasmonic biosensor that utilizes gold nanorods (Au NRs) for the detection of COVID-19 SARS-CoV-2 spike protein is presented. Simulation results for different prismatic configurations for the basic Kretschmann layout are presented. It is found that a BK7 glass prism-based SPR sensor has an incremental sensitivity of 111.11 deg RIU-1. Additionally, using Comsol Multiphysics the electric field enhancement observed for various aspect ratios and layouts of Au NRs are discussed in depth.The beautiful interplay between light and matter can give rise to many striking physical phenomena, surface plasmon resonance (SPR) being one of them. Plasmonic immunosensors monitor refractive index changes that occur as a result of specific ligand-analyte or antibody-antigen interactions taking place on the sensor surface. The coronavirus disease (COVID-19) pandemic has jeopardized the entire world and has resulted in economic slowdown of most countries. In this work, a model of a sandwich plasmonic biosensor that utilizes gold nanorods (Au NRs) for the detection of COVID-19 SARS-CoV-2 spike protein is presented. Simulation results for different prismatic configurations for the basic Kretschmann layout are presented. It is found that a BK7 glass prism-based SPR sensor has an incremental sensitivity of 111.11 deg RIU-1. Additionally, using Comsol Multiphysics the electric field enhancement observed for various aspect ratios and layouts of Au NRs are discussed in depth.
The beautiful interplay between light and matter can give rise to many striking physical phenomena, surface plasmon resonance (SPR) being one of them. Plasmonic immunosensors monitor refractive index changes that occur as a result of specific ligand–analyte or antibody–antigen interactions taking place on the sensor surface. The coronavirus disease (COVID‐19) pandemic has jeopardized the entire world and has resulted in economic slowdown of most countries. In this work, a model of a sandwich plasmonic biosensor that utilizes gold nanorods (Au NRs) for the detection of COVID‐19 SARS‐CoV‐2 spike protein is presented. Simulation results for different prismatic configurations for the basic Kretschmann layout are presented. It is found that a BK7 glass prism‐based SPR sensor has an incremental sensitivity of 111.11 deg RIU −1 . Additionally, using Comsol Multiphysics the electric field enhancement observed for various aspect ratios and layouts of Au NRs are discussed in depth.
The beautiful interplay between light and matter can give rise to many striking physical phenomena, surface plasmon resonance (SPR) being one of them. Plasmonic immunosensors monitor refractive index changes that occur as a result of specific ligand–analyte or antibody–antigen interactions taking place on the sensor surface. The coronavirus disease (COVID‐19) pandemic has jeopardized the entire world and has resulted in economic slowdown of most countries. In this work, a model of a sandwich plasmonic biosensor that utilizes gold nanorods (Au NRs) for the detection of COVID‐19 SARS‐CoV‐2 spike protein is presented. Simulation results for different prismatic configurations for the basic Kretschmann layout are presented. It is found that a BK7 glass prism‐based SPR sensor has an incremental sensitivity of 111.11 deg RIU−1. Additionally, using Comsol Multiphysics the electric field enhancement observed for various aspect ratios and layouts of Au NRs are discussed in depth. The coronavirus disease (COVID‐19) pandemic has adversely affected the entire world, where apart from stressing the medical fraternity, it has resulted in a major economic slowdown. In this paper, a unique detection scheme for quantifying SARS‐CoV‐2 virus using a plasmonic immunosensor that uses gold nanorods for signal amplification is presented.
The beautiful interplay between light and matter can give rise to many striking physical phenomena, surface plasmon resonance (SPR) being one of them. Plasmonic immunosensors monitor refractive index changes that occur as a result of specific ligand–analyte or antibody–antigen interactions taking place on the sensor surface. The coronavirus disease (COVID‐19) pandemic has jeopardized the entire world and has resulted in economic slowdown of most countries. In this work, a model of a sandwich plasmonic biosensor that utilizes gold nanorods (Au NRs) for the detection of COVID‐19 SARS‐CoV‐2 spike protein is presented. Simulation results for different prismatic configurations for the basic Kretschmann layout are presented. It is found that a BK7 glass prism‐based SPR sensor has an incremental sensitivity of 111.11 deg RIU −1 . Additionally, using Comsol Multiphysics the electric field enhancement observed for various aspect ratios and layouts of Au NRs are discussed in depth. The coronavirus disease (COVID‐19) pandemic has adversely affected the entire world, where apart from stressing the medical fraternity, it has resulted in a major economic slowdown. In this paper, a unique detection scheme for quantifying SARS‐CoV‐2 virus using a plasmonic immunosensor that uses gold nanorods for signal amplification is presented.
Author Guo, Yan
Xu, Gaixia
Yang, Guang
Das, Chandreyee Manas
Ho, Ho‐Pui
Yong, Ken‐Tye
Kang, Lixing
AuthorAffiliation 5 Department of Biomedical Engineering The Chinese University of Hong Kong New Territories Hong Kong SAR 999077 China
4 Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging Department of Biomedical Engineering School of Medicine Shenzhen University Shenzhen 518060 China
1 CINTRA CNRS/NTU/THALES UMI 3288 Research Techno Plaza 50 Nanyang Drive Border X Block Singapore 637553 Singapore
3 School of Automation Hangzhou Dianzi University Hangzhou Zhejiang 310018 China
2 School of Electrical and Electronic Engineering Nanyang Technological University 50 Nanyang Avenue Singapore 639798 Singapore
AuthorAffiliation_xml – name: 4 Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging Department of Biomedical Engineering School of Medicine Shenzhen University Shenzhen 518060 China
– name: 5 Department of Biomedical Engineering The Chinese University of Hong Kong New Territories Hong Kong SAR 999077 China
– name: 2 School of Electrical and Electronic Engineering Nanyang Technological University 50 Nanyang Avenue Singapore 639798 Singapore
– name: 1 CINTRA CNRS/NTU/THALES UMI 3288 Research Techno Plaza 50 Nanyang Drive Border X Block Singapore 637553 Singapore
– name: 3 School of Automation Hangzhou Dianzi University Hangzhou Zhejiang 310018 China
Author_xml – sequence: 1
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  surname: Das
  fullname: Das, Chandreyee Manas
  organization: Nanyang Technological University
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  givenname: Yan
  surname: Guo
  fullname: Guo, Yan
  organization: Hangzhou Dianzi University
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  fullname: Yang, Guang
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  givenname: Ho‐Pui
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  givenname: Ken‐Tye
  orcidid: 0000-0001-7936-2941
  surname: Yong
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  email: ktyong@ntu.edu.sg
  organization: Nanyang Technological University
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Snippet The beautiful interplay between light and matter can give rise to many striking physical phenomena, surface plasmon resonance (SPR) being one of them....
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SubjectTerms COVID‐19
gold nanorods
kretschmann layouts
plasmonic immunosensors
Title Gold Nanorod Assisted Enhanced Plasmonic Detection Scheme of COVID‐19 SARS‐CoV‐2 Spike Protein
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fadts.202000185
https://www.proquest.com/docview/2459624958
https://pubmed.ncbi.nlm.nih.gov/PMC7646005
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