Improved sacral neuromodulation in the treatment of the hyperactive detrusor: signal modification in an animal model

• Published in: BJU international Vol. 91; no. 7; pp. 711 - 715
• Main Authors: Seif, C., Cherwon, E., Martinez Portilló, F.J., Alken, P., Jünemann, K.P., Braun, P.M.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.05.2003; Blackwell
• Subjects: Animals; Biological and medical sciences; Electric Stimulation; hyperactive detrusor; Lumbosacral Plexus - physiology; Medical sciences; Muscle Contraction - physiology; Nephrology. Urinary tract diseases; overactive bladder; Peripheral Nervous System - physiology; Pressure; QT‐stimulation; sacral neuromodulation; selective neuromodulation; Signal Transduction; Swine; Urinary Bladder Diseases - physiopathology; Urinary Bladder Diseases - therapy; Urinary system involvement in other diseases. Miscellaneous; Urinary tract. Prostate gland; Urodynamics; Animal model; QT-stimulation; Stimulation; Neuromodulation; hyperactive detrusor; sacral neuromodulation; selective neuromodulation; Electrodiagnosis; Detrusor muscle; Electromyography; Minipig; Ungulata; Sacral nerve; Urinary system disease; Treatment efficiency; Instrumentation therapy; Experimental study; Muscle contraction; Neurophysiology; Unstable bladder; Vertebrata; Mammalia; Animal; Bladder disease; Artiodactyla; Signal analysis; overactive bladder

OBJECTIVE To investigate different stimulation signals for the peripheral nerve evaluation test (PNE, carried out before implanting a sacral neuromodulator for functional voiding dysfunction) in an animal model and to determine their efficacy, as up to 80% of patients do not respond to the PNE test....