Long‐term regulation of signalling components of adenylyl cyclase and mitogen‐activated protein kinase in the pre‐frontal cortex of human opiate addicts - Ferrer‐Alcón, M.; J. García‐Fuster, M.; La Harpe, R; García‐Sevilla, J. A. (Journal of neurochemistry, 2004)
Keywords: Adenylyl Cyclases - metabolism; Adolescent; Adult; Animals; Biological and medical sciences; cAMP signalling; Cell Line; Chronic Disease; Cyclic AMP Response Element-Binding Protein - drug effects; Cyclic AMP Response Element-Binding Protein - metabolism; Cyclic AMP-Dependent Protein Kinases - drug effects; Cyclic AMP-Dependent Protein Kinases - metabolism; Disease Models, Animal; Dose-Response Relationship, Drug; Drug addictions; Enzyme Inhibitors - pharmacology; Female; human post‐mortem brain; Humans; Male; MAPK signalling; Medical sciences; Middle Aged; Mitogen-Activated Protein Kinase 1 - drug effects; Mitogen-Activated Protein Kinase 1 - metabolism; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases - drug effects; Mitogen-Activated Protein Kinase Kinases - metabolism; Mitogen-Activated Protein Kinases - drug effects; Mitogen-Activated Protein Kinases - metabolism; Morphine - pharmacology; opiate addiction; Opioid-Related Disorders - metabolism; Opioid-Related Disorders - pathology; Prefrontal Cortex - drug effects; Prefrontal Cortex - metabolism; Prefrontal Cortex - pathology; Proto-Oncogene Proteins c-raf - drug effects; Proto-Oncogene Proteins c-raf - metabolism; ras Proteins - drug effects; ras Proteins - metabolism; rat brain; Rats; Rats, Sprague-Dawley; SH‐SY5Y cells; Signal Transduction - drug effects; Time; Toxicology; Phosphorylation; Rat; Toxicity; Central nervous system; μ Opioid receptor; Opiates; Frontal cortex; Protein kinase Raf-1; Encephalon; cAMP signalling; Signal transduction; human post-mortem brain; Dependence; Plasticity; Transcription factor CREB; Enzyme; Rodentia; Mitogen-activated protein kinase; rat brain; Gene expression; MAPK signalling; Vertebrata; opiate addiction; Mammalia; Addiction; Animal; SH-SY5Y cells