Vitamin E and changes in serum alanine aminotransferase levels in patients with non‐alcoholic steatohepatitis

• Published in: Alimentary pharmacology & therapeutics Vol. 38; no. 2; pp. 134 - 143
• Main Authors: Hoofnagle, J. H., Natta, M. L., Kleiner, D. E., Clark, J. M., Kowdley, K. V., Loomba, R., Neuschwander‐Tetri, B. A., Sanyal, A. J., Tonascia, J.
• Format: Journal Article
• Language: English
• Published: Oxford Blackwell 01.07.2013
• Subjects: Adult; Alanine Transaminase - blood; Antioxidants - therapeutic use; Biological and medical sciences; Digestive system; Fatty Liver - drug therapy; Fatty Liver - enzymology; Female; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Hypoglycemic Agents - therapeutic use; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; Medical sciences; Middle Aged; Non-alcoholic Fatty Liver Disease; Other diseases. Semiology; Pharmacology. Drug treatments; Thiazolidinediones - therapeutic use; Vitamin E - therapeutic use; Weight Loss; Human; Biological fluid; Enzyme; Vitamin E; Transaminases; Transferases; Non alcoholic steatohepatitis; Alanine transaminase; Digestive diseases; Hepatic disease; Serum

Summary Background Non‐alcoholic steatohepatitis (NASH) is a common cause of serum alanine aminotransferase (ALT) elevations and chronic liver disease, but it is unclear how well ALT elevations reflect the liver injury. Aim To assess how well changes in ALT elevations reflect improvements in liver h...