Acute Kidney Injury in Patients Treated with Vancomycin and Piperacillin‐Tazobactam: A Retrospective Cohort Analysis

• Published in: Journal of hospital medicine Vol. 12; no. 2; pp. 77 - 82
• Main Authors: Rutter, W. Cliff, Burgess, Donna R., Talbert, Jeffery C., Burgess, David S.
• Format: Journal Article
• Language: English
• Published: United States Frontline Medical Communications 01.02.2017
• Subjects: Acute Kidney Injury - chemically induced; Acute Kidney Injury - epidemiology; Anti-Bacterial Agents - therapeutic use; Antibiotics; Cohort analysis; Drug Therapy, Combination; Female; Humans; Incidence; Kidneys; Male; Middle Aged; Penicillanic Acid - analogs & derivatives; Penicillanic Acid - therapeutic use; Piperacillin - therapeutic use; Retrospective Studies; Vancomycin - therapeutic use

BACKGROUND Empiric antimicrobial therapy often consists of the combination of gram‐positive coverage with vancomycin (VAN) and gram‐negative coverage, specifically an antipseudomonal beta‐lactam such as piperacillin‐tazobactam (PTZ). Nephrotoxicity is commonly associated with VAN therapy; however, r...