Ethyl diazoacetate synthesis in flow

• Published in: Beilstein journal of organic chemistry Vol. 9; no. 1; pp. 1813 - 1818
• Main Authors: Delville, Mariëlle M E, van Hest, Jan C M, Rutjes, Floris P J T
• Format: Journal Article
• Language: English
• Published: Germany Beilstein-Institut 05.09.2013
• Subjects: Chemistry; diazo compounds; diazotization; ethyl diazoacetate (EDA); flow chemistry; Full Research Paper; microreactor technology; diazotization; diazo compounds; ethyl diazoacetate (EDA); microreactor technology; flow chemistry

Ethyl diazoacetate is a versatile compound in organic chemistry and frequently used on lab scale. Its highly explosive nature, however, severely limits its use in industrial processes. The in-line coupling of microreactor synthesis and separation technology enables the synthesis of this compound in...