Wedelolactone, an Anti-inflammatory Botanical, Interrupts c-Myc Oncogenic Signaling and Synergizes with Enzalutamide to Induce Apoptosis in Prostate Cancer Cells

• Published in: Molecular cancer therapeutics Vol. 15; no. 11; pp. 2791 - 2801
• Main Authors: Sarveswaran, Sivalokanathan, Ghosh, Ritisha, Parikh, Rujul, Ghosh, Jagadananda
• Format: Journal Article
• Language: English
• Published: United States 01.11.2016
• Subjects: Animals; Apoptosis - drug effects; Cell Line, Tumor; Cell Survival - drug effects; Coumarins - pharmacology; Disease Models, Animal; Drug Synergism; Gene Expression Regulation, Neoplastic - drug effects; Humans; Male; Mice; Neoplastic Stem Cells - drug effects; Neoplastic Stem Cells - metabolism; Phenylthiohydantoin - analogs & derivatives; Phenylthiohydantoin - pharmacology; Prostatic Neoplasms - genetics; Prostatic Neoplasms - metabolism; Protein Transport; Proto-Oncogene Proteins c-myc - genetics; Proto-Oncogene Proteins c-myc - metabolism; Signal Transduction - drug effects; Tumor Stem Cell Assay; Xenograft Model Antitumor Assays

The c-Myc gene encodes an oncoprotein transcription factor that is frequently upregulated in almost all cancer types and is the subject of intense investigation for management of cancer because of its pleiotropic effects controlling a spectrum of cellular functions. However, due of its nonenzymatic...