Assessment of K-Ras mutant frequency and micronucleus incidence in the mouse duodenum following 90-days of exposure to Cr(VI) in drinking water

• Published in: Mutation research Vol. 754; no. 1-2; pp. 15 - 21
• Main Authors: O’Brien, Travis J., Ding, Hao, Suh, Mina, Thompson, Chad M., Parsons, Barbara L., Harris, Mark A., Winkelman, William A., Wolf, Jeffrey C., Hixon, J. Gregory, Schwartz, Arnold M., Myers, Meagan B., Haws, Laurie C., Proctor, Deborah M.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 14.06.2013; Elsevier BV
• Subjects: Animals; Base Sequence; Cancer risk assessment; Carcinogenesis; Chromium; Chromium - toxicity; Codon; Cytotoxicity; DNA Primers; Drinking Water; Duodenum - drug effects; Duodenum - metabolism; Female; Genes, ras; Genotoxicity; Hexavalent chromium; K-Ras; Mice; Micronucleus; Micronucleus Tests; Mode of action; Mutation; Polymerase Chain Reaction; Rodents; Small intestine; Tumors; Hexavalent chromium; Mutation; K-Ras; Micronucleus; Cancer risk assessment

•Cr(VI) did not significantly affect mitotic or apoptotic indices in the duodenum.•Cr(VI) did not increase micronuclei and karyorrhectic nuclei in the duodenal crypts.•Cr(VI) did not increase K-Ras codon 12 GAT mutations in mouse duodenum.•Data support that Cr(VI) induces small intestinal tumors in...