Cumulative Effects of Aging and Mechanical Ventilation on In Vitro Diaphragm Function

• Published in: Chest Vol. 124; no. 6; pp. 2302 - 2308
• Main Authors: Criswell, David S., Shanely, R. Andrew, Betters, Jenna J., McKenzie, Michael J., Sellman, Jeff E., Van Gammeren, Darin L., Powers, Scott K.
• Format: Journal Article
• Language: English
• Published: Northbrook, IL Elsevier Inc 01.12.2003; American College of Chest Physicians
• Subjects: Age; Aging; Aging - metabolism; Aging - physiology; Airway management; Anesthesia; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Animals; artificial respiration; Biological and medical sciences; Cardiology. Vascular system; Catheters; contractile function; diaphragm; Diaphragm (Anatomy); Diaphragm - metabolism; Diaphragm - physiology; Drugs; Electric Stimulation; Homeostasis; Hypotheses; Male; Medical sciences; Muscle Contraction - physiology; Musculoskeletal system; Older people; Oxidation; Oxidative stress; Pneumology; Rats; Rats, Inbred F344; Respiration; Respiration, Artificial; Sodium; Ventilators; Weaning; Young adults; Norway; contractile function; artificial respiration; diaphragm; MV; TPT; aging; Ageing; Anesthesia; Circulatory system; Diaphragm; Artificial ventilation; Cardiology; Respiration; In vitro; Mechanical ventilation

Unloading the diaphragm, via mechanical ventilation (MV), results in significant diaphragmatic atrophy, contractile dysfunction, and oxidative stress in young adult animals. Since aging increases skeletal muscle susceptibility to atrophy and injury, we tested the hypothesis that MV-induced diaphragm...