Bioinformatic analysis reveals an evolutional selection for DNA:RNA hybrid G-quadruplex structures as putative transcription regulatory elements in warm-blooded animals

• Published in: Nucleic acids research Vol. 41; no. 22; pp. 10379 - 10390
• Main Authors: Xiao, Shan, Zhang, Jia-Yu, Zheng, Ke-Wei, Hao, Yu-Hua, Tan, Zheng
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.12.2013
• Subjects: Animals; Computational Biology; DNA - chemistry; Evolution, Molecular; G-Quadruplexes; Genomics; Regulatory Elements, Transcriptional; RNA - chemistry; Selection, Genetic; Transcription Initiation Site

Recently, we reported the co-transcriptional formation of DNA:RNA hybrid G-quadruplex (HQ) structure by the non-template DNA strand and nascent RNA transcript, which in turn modulates transcription under both in vitro and in vivo conditions. Here we present bioinformatic analysis on putative HQ-form...