Primary Cardiac Intimal Sarcoma: Multi-Layered Strategy and Core Role of MDM2 Amplification/Co-Amplification and MDM2 Immunostaining

• Published in: Diagnostics (Basel) Vol. 14; no. 9; p. 919
• Main Authors: Nistor, Claudiu, Stanciu Gavan, Camelia, Birceanu, Adelina, Betianu, Cezar, Carsote, Mara, Cucu, Anca-Pati, Stanciu, Mihaela, Popa, Florina, Ciuche, Adrian, Ciobica, Mihai-Lucian
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 28.04.2024
• Subjects: Biopsy; cardiac sarcoma; Case reports; Chemotherapy; dyspnoea; Epidemiology; Gene amplification; Heart failure; heart surgery; immunohistochemistry; MDM2; Medical prognosis; Metastasis; Patients; Sarcoma; Surgery; Surveillance; Tomography; Transplants & implants; Tumors; ultrasound-guided cardiac coaxial needle biopsy; heart surgery; MDM2; cardiac sarcoma; gene testing; immunohistochemistry; dyspnoea; ultrasound-guided cardiac coaxial needle biopsy

Primary cardiac tumours are relatively uncommon (75% are benign). Across the other 25%, representing malignant neoplasia, sarcomas account for 75–95%, and primary cardiac intimal sarcoma (PCIS) is one of the rarest findings. We aimed to present a comprehensive review and practical considerations fro...