Antimicrobial resistance of diarrheagenic Escherichia coli isolated from children under the age of 5 years from Ifakara, Tanzania
Diarrhea caused by multidrug-resistant bacteria is an important public health problem among children in developing countries. The prevalence and antimicrobial susceptibility of diarrheagenic Escherichia coli in 346 children under 5 years of age in Ifakara, Tanzania, were studied. Thirty-eight percen...
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| Published in | Antimicrobial agents and chemotherapy Vol. 43; no. 12; pp. 3022 - 3024 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Washington, DC
American Society for Microbiology
01.12.1999
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| Series | Note |
| Subjects | |
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| Abstract | Diarrhea caused by multidrug-resistant bacteria is an important public health problem among children in developing countries. The prevalence and antimicrobial susceptibility of diarrheagenic Escherichia coli in 346 children under 5 years of age in Ifakara, Tanzania, were studied. Thirty-eight percent of the cases of diarrhea were due to multiresistant enterotoxigenic E. coli, enteroaggregative E. coli, or enteropathogenic E. coli. Strains of all three E. coli categories showed high-level resistance to ampicillin, tetracycline, co-trimoxazole, and chloramphenicol but were highly susceptible to quinolones. Guidelines for appropriate use of antibiotics in developing countries need updating. |
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| AbstractList | Diarrhea caused by multidrug-resistant bacteria is an important public health problem among children in developing countries. The prevalence and antimicrobial susceptibility of diarrheagenic
Escherichia coli
in 346 children under 5 years of age in Ifakara, Tanzania, were studied. Thirty-eight percent of the cases of diarrhea were due to multiresistant enterotoxigenic
E. coli
, enteroaggregative
E. coli
, or enteropathogenic
E. coli
. Strains of all three
E. coli
categories showed high-level resistance to ampicillin, tetracycline, co-trimoxazole, and chloramphenicol but were highly susceptible to quinolones. Guidelines for appropriate use of antibiotics in developing countries need updating. ABSTRACT Diarrhea caused by multidrug-resistant bacteria is an important public health problem among children in developing countries. The prevalence and antimicrobial susceptibility of diarrheagenic Escherichia coli in 346 children under 5 years of age in Ifakara, Tanzania, were studied. Thirty-eight percent of the cases of diarrhea were due to multiresistant enterotoxigenic E. coli , enteroaggregative E. coli , or enteropathogenic E. coli . Strains of all three E. coli categories showed high-level resistance to ampicillin, tetracycline, co-trimoxazole, and chloramphenicol but were highly susceptible to quinolones. Guidelines for appropriate use of antibiotics in developing countries need updating. Diarrhea caused by multidrug-resistant bacteria is an important public health problem among children in developing countries. The prevalence and antimicrobial susceptibility of diarrheagenic Escherichia coli in 346 children under 5 years of age in Ifakara, Tanzania, were studied. Thirty-eight percent of the cases of diarrhea were due to multiresistant enterotoxigenic E. coli, enteroaggregative E. coli, or enteropathogenic E. coli. Strains of all three E. coli categories showed high-level resistance to ampicillin, tetracycline, co-trimoxazole, and chloramphenicol but were highly susceptible to quinolones. Guidelines for appropriate use of antibiotics in developing countries need updating. |
| Author | GASCON, J SCHELLEMBERG, D CASALS, C URASSA, H VILA, J MSHINDA, H VARGAS, M |
| AuthorAffiliation | Departament de Microbiologia, Hospital Clinic, IDIBAPS (Institut d’Investigacions Biomèdiques August Pí i Sunyer), Barcelona 08036, Spain, 1 and Ifakara Health Research and Development Centre, National Institute for Medical Research, Ifakara, Tanzania 2 |
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| Cites_doi | 10.1128/CMR.11.1.142 10.1136/bmj.317.7159.651 10.3201/eid0303.970317 10.1111/j.1469-0691.1998.tb00652.x 10.1099/00222615-47-9-781 10.3201/eid0402.980212 10.1016/S0140-6736(96)07493-4 10.1093/clinids/4.2.540 10.1185/03007999709113341 |
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| Keywords | Human Toxicity Escherichia coli Diarrhea Epidemiology Resistance Antibiotic Digestive diseases Bacteria Intestinal disease Antibacterial agent Child Public health Enterobacteriaceae |
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| References | 9524792 - Curr Med Res Opin. 1997;14(1):39-45 9457432 - Clin Microbiol Rev. 1998 Jan;11(1):142-201 9621195 - Emerg Infect Dis. 1998 Apr-Jun;4(2):251-61 9727996 - BMJ. 1998 Sep 5;317(7159):651 9142060 - Lancet. 1997 May 3;349(9061):1269-76 9284385 - Emerg Infect Dis. 1997 Jul-Sep;3(3):373-4 9736160 - J Med Microbiol. 1998 Sep;47(9):781-90 7051247 - Rev Infect Dis. 1982 Mar-Apr;4(2):540-5 11864275 - Clin Microbiol Infect. 1998 Feb;4(12):682-688 Black R. E. (e_1_3_2_2_2) 1982; 4 e_1_3_2_7_2 e_1_3_2_6_2 Sang W. K. (e_1_3_2_9_2) 1997; 3 Murray C. J. L. (e_1_3_2_4_2) 1997; 349 Rosa A. C. P. (e_1_3_2_8_2) 1998; 47 e_1_3_2_10_2 Williams R. J. (e_1_3_2_11_2) 1998; 317 e_1_3_2_5_2 Frisari L. (e_1_3_2_3_2) 1997; 14 |
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| Snippet | Diarrhea caused by multidrug-resistant bacteria is an important public health problem among children in developing countries. The prevalence and antimicrobial... ABSTRACT Diarrhea caused by multidrug-resistant bacteria is an important public health problem among children in developing countries. The prevalence and... |
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| SubjectTerms | Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Child, Preschool Diarrhea - microbiology DNA, Bacterial - chemistry DNA, Bacterial - genetics Drug Resistance, Microbial Drug Resistance, Multiple Escherichia coli Escherichia coli - drug effects Escherichia coli Infections - microbiology Feces - microbiology Genes, Bacterial Humans Infant Medical sciences Microbial Sensitivity Tests Pharmacology. Drug treatments Polymerase Chain Reaction Susceptibility Tanzania |
| Title | Antimicrobial resistance of diarrheagenic Escherichia coli isolated from children under the age of 5 years from Ifakara, Tanzania |
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