Novel small GTPase M-Ras participates in reorganization of actin cytoskeleton

• Published in: Oncogene Vol. 15; no. 20; pp. 2409 - 2417
• Main Authors: MATSUMOTO, K, ASANO, T, ENDO, T
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing 13.11.1997; Nature Publishing Group
• Subjects: 3T3 Cells - metabolism; 3T3 Cells - ultrastructure; Actin; Actins - metabolism; Amino Acid Sequence; Animals; Base Sequence; Biological and medical sciences; Cell differentiation; Cell Line; Cell membranes; Cell physiology; Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes; Cloning, Molecular; Cytoskeleton; Cytoskeleton - metabolism; Cytoskeleton - ultrastructure; DNA, Complementary - genetics; Epitopes; Fibroblasts; Fundamental and applied biological sciences. Psychology; Genes; GTP Phosphohydrolases - genetics; GTP Phosphohydrolases - physiology; Guanosine triphosphatases; Guanosine triphosphate; Guanosine Triphosphate - physiology; Mice; Microinjection; Microinjections; Molecular and cellular biology; Molecular Sequence Data; Monomeric GTP-Binding Proteins; Muscle, Skeletal - enzymology; Musculoskeletal system; Mutagenesis, Site-Directed; Organ Specificity; Ras protein; Rats; Sequence Alignment; Sequence Homology, Amino Acid; Skeletal muscle; Species Specificity; Subcellular Fractions - chemistry; Transfection; GTP; Nucleotide sequence; Enzyme; Triphosphoric monoester hydrolases; Rodentia; Contractile protein; dGTPase; Homology; Esterases; Gene expression; Binding protein; Vertebrata; Mammalia; Cell line; Microinjection; Enzymatic activity; Gene; Mouse; Actin; Hydrolases; Cytoskeleton; Multigene family; Mutation; G protein

During an attempt to elucidate regulatory mechanisms of skeletal muscle cell differentiation, we cloned cDNAs encoding a novel small GTPase from cDNA libraries of the mouse skeletal muscle cell line C2 and rat brain. It was designated as M-Ras due to the structural similarity to Ras family proteins....