Methylation-associated silencing of miR-193a-3p promotes ovarian cancer aggressiveness by targeting GRB7 and MAPK/ERK pathways

• Published in: Theranostics Vol. 8; no. 2; pp. 423 - 436
• Main Authors: Chen, Kangmei, Liu, Michelle Xin, Mak, Celia Sze-Ling, Yung, Mingo Ming-Ho, Leung, Thomas Ho-Yin, Xu, Dakang, Ngu, Siew-Fei, Chan, Karen Kar-Loen, Yang, Huijuan, Ngan, Hextan Yuen-Sheung, Chan, David Wai
• Format: Journal Article
• Language: English
• Published: Australia Ivyspring International Publisher 2018
• Subjects: Animals; Carcinogenesis - genetics; Cell Line, Tumor; Cell Movement - genetics; Cell Proliferation - genetics; Female; Gene Expression Regulation, Neoplastic - genetics; Gene Silencing - physiology; GRB7 Adaptor Protein - genetics; Humans; MAP Kinase Signaling System - genetics; Methylation; Mice; Mice, Inbred BALB C; Mice, Nude; MicroRNAs - genetics; Ovarian Neoplasms - genetics; Research Paper; RNA Interference - physiology; Signal Transduction - genetics; Up-Regulation - genetics; GRB7; DNA hypermethylation; ovarian cancer; miR-193a-3p; MAPK signaling

Human growth factor receptor-bound protein-7 (GRB7) is a pivotal mediator involved in receptor tyrosine kinase signaling and governing diverse cellular processes. Aberrant upregulation of GRB7 is frequently associated with the progression of human cancers. However, the molecular mechanisms leading t...