Role of Kupffer cells in acute hemorrhagic necrotizing pancreatitis-associated lung injury of rats

• Published in: World journal of gastroenterology : WJG Vol. 12; no. 3; pp. 403 - 407
• Main Authors: Liu, Hong-Bin, Cui, Nai-Qiang, Li, Dong-Hua, Chen, Chang
• Format: Journal Article
• Language: English
• Published: United States Department of Pharmacology,Tianjin Institute of Acute Abdominal Diseases, Tianjin 300100,China%Second Department of Surgery,Tianjin Institute of Acute Abdominal Diseases, Tianjin 300100,China 21.01.2006; Baishideng Publishing Group Co., Limited
• Subjects: Amylases - blood; Animals; Anti-Inflammatory Agents - therapeutic use; Basic Research; Gadolinium - therapeutic use; Interleukin-1 - blood; Kupffer Cells - cytology; Kupffer Cells - immunology; Lung; Male; Pancreatitis, Acute Necrotizing - complications; Pancreatitis, Acute Necrotizing - drug therapy; Pancreatitis, Acute Necrotizing - immunology; Pancreatitis, Acute Necrotizing - pathology; Peroxidase - metabolism; Random Allocation; Rats; Rats, Wistar; Respiratory Distress Syndrome, Adult - drug therapy; Respiratory Distress Syndrome, Adult - etiology; Respiratory Distress Syndrome, Adult - immunology; Respiratory Distress Syndrome, Adult - pathology; Tumor Necrosis Factor-alpha - metabolism; 动物实验; 急性出血性胰腺炎; 疾病机制; 肺损伤; Kupffer cell; NF-κB; Pancreatitis-associated lung injury; Gadolinium chloride

AIM： To investigate the role of Kupffer cells （KCs） in acute hemorrhagic necrotizing pancreatitis-associated lung injury （AHNP-U）. METHODS： Forty-two rats were allocated to four groups [sham operation, AHNP model, gadolinium chloride （GdCl3） pretreatment, GdCl3 control]. In GdCl3 pretreatment group,...