Selective Autophagy Regulates Cell Cycle in Cancer Therapy

• Published in: Theranostics Vol. 9; no. 1; pp. 104 - 125
• Main Authors: Zheng, Kai, He, Zhendan, Kitazato, Kaio, Wang, Yifei
• Format: Journal Article
• Language: English
• Published: Australia Ivyspring International Publisher 2019
• Subjects: Antineoplastic Agents - pharmacology; Autophagy; Cell Cycle; Gene Expression Regulation - drug effects; Molecular Targeted Therapy - methods; Neoplasms - drug therapy; Review; senescence; DNA damage repair; cell cycle checkpoints; chemoresistance; selective autophagy

Aberrant function of cell cycle regulators results in uncontrolled cell proliferation, making them attractive therapeutic targets in cancer treatment. Indeed, survival of many cancers exclusively relies on these proteins, and several specific inhibitors are in clinical use. Although the ubiquitin-pr...