Natural History of Rising Serum Prostate-Specific Antigen in Men With Castrate Nonmetastatic Prostate Cancer
To describe the natural history of nonmetastatic prostate cancer and rising prostate-specific antigen (PSA) despite androgen deprivation therapy. The 201 patients in this report were the placebo control group from an aborted randomized controlled trial to evaluate the effects of zoledronic acid on t...
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Published in | Journal of clinical oncology Vol. 23; no. 13; pp. 2918 - 2925 |
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Main Authors | , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Baltimore, MD
American Society of Clinical Oncology
01.05.2005
Lippincott Williams & Wilkins |
Subjects | |
Online Access | Get full text |
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Abstract | To describe the natural history of nonmetastatic prostate cancer and rising prostate-specific antigen (PSA) despite androgen deprivation therapy.
The 201 patients in this report were the placebo control group from an aborted randomized controlled trial to evaluate the effects of zoledronic acid on time to first bone metastasis in men with prostate cancer, no bone metastases, and rising PSA despite androgen deprivation therapy. Relationships between baseline covariates and clinical outcomes were assessed by Cox proportional hazard analyses. Covariates in the model were baseline PSA, Gleason sum, history of bilateral orchiectomies, regional lymph node metastases at diagnosis, prior prostatectomy, time from androgen deprivation therapy to random assignment, time from diagnosis to random assignment, and PSA velocity.
At 2 years, 33% of patients had developed bone metastases. Median bone metastasis-free survival was 30 months. Median time to first bone metastases and overall survival were not reached. Baseline PSA level greater than 10 ng/mL (relative risk, 3.18; 95% CI, 1.74 to 5.80; P < .001) and PSA velocity (4.34 for each 0.01 increase in PSA velocity; 95% CI, 2.30 to 8.21; P < .001) independently predicted shorter time to first bone metastasis. Baseline PSA and PSA velocity also independently predicted overall survival and metastasis-free survival. Other covariates did not consistently predict clinical outcomes.
Men with nonmetastatic prostate cancer and rising PSA despite androgen deprivation therapy have a relatively indolent natural history. Baseline PSA and PSA velocity independently predict time to first bone metastasis and survival. |
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AbstractList | PURPOSETo describe the natural history of nonmetastatic prostate cancer and rising prostate-specific antigen (PSA) despite androgen deprivation therapy.PATIENTS AND METHODSThe 201 patients in this report were the placebo control group from an aborted randomized controlled trial to evaluate the effects of zoledronic acid on time to first bone metastasis in men with prostate cancer, no bone metastases, and rising PSA despite androgen deprivation therapy. Relationships between baseline covariates and clinical outcomes were assessed by Cox proportional hazard analyses. Covariates in the model were baseline PSA, Gleason sum, history of bilateral orchiectomies, regional lymph node metastases at diagnosis, prior prostatectomy, time from androgen deprivation therapy to random assignment, time from diagnosis to random assignment, and PSA velocity.RESULTSAt 2 years, 33% of patients had developed bone metastases. Median bone metastasis-free survival was 30 months. Median time to first bone metastases and overall survival were not reached. Baseline PSA level greater than 10 ng/mL (relative risk, 3.18; 95% CI, 1.74 to 5.80; P < .001) and PSA velocity (4.34 for each 0.01 increase in PSA velocity; 95% CI, 2.30 to 8.21; P < .001) independently predicted shorter time to first bone metastasis. Baseline PSA and PSA velocity also independently predicted overall survival and metastasis-free survival. Other covariates did not consistently predict clinical outcomes.CONCLUSIONMen with nonmetastatic prostate cancer and rising PSA despite androgen deprivation therapy have a relatively indolent natural history. Baseline PSA and PSA velocity independently predict time to first bone metastasis and survival. To describe the natural history of nonmetastatic prostate cancer and rising prostate-specific antigen (PSA) despite androgen deprivation therapy. The 201 patients in this report were the placebo control group from an aborted randomized controlled trial to evaluate the effects of zoledronic acid on time to first bone metastasis in men with prostate cancer, no bone metastases, and rising PSA despite androgen deprivation therapy. Relationships between baseline covariates and clinical outcomes were assessed by Cox proportional hazard analyses. Covariates in the model were baseline PSA, Gleason sum, history of bilateral orchiectomies, regional lymph node metastases at diagnosis, prior prostatectomy, time from androgen deprivation therapy to random assignment, time from diagnosis to random assignment, and PSA velocity. At 2 years, 33% of patients had developed bone metastases. Median bone metastasis-free survival was 30 months. Median time to first bone metastases and overall survival were not reached. Baseline PSA level greater than 10 ng/mL (relative risk, 3.18; 95% CI, 1.74 to 5.80; P < .001) and PSA velocity (4.34 for each 0.01 increase in PSA velocity; 95% CI, 2.30 to 8.21; P < .001) independently predicted shorter time to first bone metastasis. Baseline PSA and PSA velocity also independently predicted overall survival and metastasis-free survival. Other covariates did not consistently predict clinical outcomes. Men with nonmetastatic prostate cancer and rising PSA despite androgen deprivation therapy have a relatively indolent natural history. Baseline PSA and PSA velocity independently predict time to first bone metastasis and survival. Purpose To describe the natural history of nonmetastatic prostate cancer and rising prostate-specific antigen (PSA) despite androgen deprivation therapy. Patients and Methods: The 201 patients in this report were the placebo control group from an aborted randomized controlled trial to evaluate the effects of zoledronic acid on time to first bone metastasis in men with prostate cancer, no bone metastases, and rising PSA despite androgen deprivation therapy. Relationships between baseline covariates and clinical outcomes were assessed by Cox proportional hazard analyses. Covariates in the model were baseline PSA, Gleason sum, history of bilateral orchiectomies, regional lymph node metastases at diagnosis, prior prostatectomy, time from androgen deprivation therapy to random assignment, time from diagnosis to random assignment, and PSA velocity. Results At 2 years, 33% of patients had developed bone metastases. Median bone metastasis–free survival was 30 months. Median time to first bone metastases and overall survival were not reached. Baseline PSA level greater than 10 ng/mL (relative risk, 3.18; 95% CI, 1.74 to 5.80; P < .001) and PSA velocity (4.34 for each 0.01 increase in PSA velocity; 95% CI, 2.30 to 8.21; P < .001) independently predicted shorter time to first bone metastasis. Baseline PSA and PSA velocity also independently predicted overall survival and metastasis-free survival. Other covariates did not consistently predict clinical outcomes. Conclusion Men with nonmetastatic prostate cancer and rising PSA despite androgen deprivation therapy have a relatively indolent natural history. Baseline PSA and PSA velocity independently predict time to first bone metastasis and survival. |
Author | Robin Murray Fred Saad Eric J. Small Arif Hussain Ronald Linnartz Matthew R. Smith Marc C. Gittelman Ming Zheng Norman R. Zinner Chris Wynne Yong-Jiang Hei Celestia S. Higano David L. Bilhartz Richard Cook Claude Schulman Carsten Goessl Fairooz Kabbinavar |
Author_xml | – sequence: 1 givenname: Matthew R surname: SMITH fullname: SMITH, Matthew R organization: Christchurch Hospital, Christchurch, New Zealand – sequence: 2 givenname: Fairooz surname: KABBINAVAR fullname: KABBINAVAR, Fairooz organization: Christchurch Hospital, Christchurch, New Zealand – sequence: 3 givenname: Ronald surname: LINNARTZ fullname: LINNARTZ, Ronald organization: Christchurch Hospital, Christchurch, New Zealand – sequence: 4 surname: MING ZHENG fullname: MING ZHENG organization: Christchurch Hospital, Christchurch, New Zealand – sequence: 5 givenname: Carsten surname: GOESSL fullname: GOESSL, Carsten organization: Christchurch Hospital, Christchurch, New Zealand – sequence: 6 givenname: Yong-Jiang surname: HEI fullname: HEI, Yong-Jiang organization: Christchurch Hospital, Christchurch, New Zealand – sequence: 7 givenname: Eric J surname: SMALL fullname: SMALL, Eric J organization: Christchurch Hospital, Christchurch, New Zealand – sequence: 8 givenname: Richard surname: COOK fullname: COOK, Richard organization: Christchurch Hospital, Christchurch, New Zealand – sequence: 9 givenname: Celestia S surname: HIGANO fullname: HIGANO, Celestia S organization: Christchurch Hospital, Christchurch, New Zealand – sequence: 10 givenname: Fred surname: SAAD fullname: SAAD, Fred organization: Christchurch Hospital, Christchurch, New Zealand – sequence: 11 surname: ARIFHUSSAIN fullname: ARIFHUSSAIN organization: Christchurch Hospital, Christchurch, New Zealand – sequence: 12 givenname: Marc C surname: GITTELMAN fullname: GITTELMAN, Marc C organization: Christchurch Hospital, Christchurch, New Zealand – sequence: 13 givenname: David L surname: BILHARTZ fullname: BILHARTZ, David L organization: Christchurch Hospital, Christchurch, New Zealand – sequence: 14 givenname: Chris surname: WYNNE fullname: WYNNE, Chris organization: Christchurch Hospital, Christchurch, New Zealand – sequence: 15 givenname: Robin surname: MURRAY fullname: MURRAY, Robin organization: Christchurch Hospital, Christchurch, New Zealand – sequence: 16 givenname: Norman R surname: ZINNER fullname: ZINNER, Norman R organization: Christchurch Hospital, Christchurch, New Zealand – sequence: 17 givenname: Claude surname: SCHULMAN fullname: SCHULMAN, Claude organization: Christchurch Hospital, Christchurch, New Zealand |
BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16806515$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/15860850$$D View this record in MEDLINE/PubMed |
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Cites_doi | 10.1200/JCO.2002.03.061 10.1056/NEJM199707313370502 10.1016/S0360-3016(97)00082-5 10.3322/canjclin.54.1.8 10.1093/jnci/djg043 10.1002/9781118032985 10.1002/(SICI)1097-0142(19981101)83:9<1989::AID-CNCR15>3.0.CO;2-V 10.1046/j.1464-410X.1997.d01-6840.x 10.1016/S0025-6196(11)62406-3 10.1056/NEJM199912093412401 10.1200/jco.2004.22.90140.4511 10.1056/NEJMoa041318 10.1001/jama.281.17.1591 10.1016/S0022-5347(01)64238-1 10.1200/JCO.1997.15.1.230 10.1016/S0360-3016(00)00717-3 10.1056/NEJMoa040720 |
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Snippet | To describe the natural history of nonmetastatic prostate cancer and rising prostate-specific antigen (PSA) despite androgen deprivation therapy.
The 201... Purpose To describe the natural history of nonmetastatic prostate cancer and rising prostate-specific antigen (PSA) despite androgen deprivation therapy.... PURPOSETo describe the natural history of nonmetastatic prostate cancer and rising prostate-specific antigen (PSA) despite androgen deprivation... |
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SubjectTerms | Aged Androgen Antagonists - therapeutic use Biological and medical sciences Biomarkers, Tumor - analysis Bone Neoplasms - prevention & control Bone Neoplasms - secondary Diphosphonates - therapeutic use Disease Progression Double-Blind Method Follow-Up Studies Humans Imidazoles - therapeutic use Male Medical sciences Nephrology. Urinary tract diseases Placebos Predictive Value of Tests Prognosis Prostate-Specific Antigen - analysis Prostatic Neoplasms - drug therapy Prostatic Neoplasms - pathology Survival Analysis Tumors Tumors of the urinary system Urinary tract. Prostate gland Zoledronic Acid |
Title | Natural History of Rising Serum Prostate-Specific Antigen in Men With Castrate Nonmetastatic Prostate Cancer |
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