Structural and biochemical insights into NEIL2’s preference for abasic sites

• Published in: Nucleic acids research Vol. 51; no. 22; pp. 12508 - 12521
• Main Authors: Eckenroth, Brian E, Bumgarner, Joshua D, Matsumoto-Elliott, Olivia, David, Sheila S, Doublié, Sylvie
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 11.12.2023
• Subjects: Biochemistry & Molecular Biology; INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; Structural Biology

Abstract Cellular DNA is subject to damage from a multitude of sources and repair or bypass of sites of damage utilize an array of context or cell cycle dependent systems. The recognition and removal of oxidatively damaged bases is the task of DNA glycosylases from the base excision repair pathway u...