eRF1 mediates codon usage effects on mRNA translation efficiency through premature termination at rare codons

• Published in: Nucleic acids research Vol. 47; no. 17; pp. 9243 - 9258
• Main Authors: Yang, Qian, Yu, Chien-Hung, Zhao, Fangzhou, Dang, Yunkun, Wu, Cheng, Xie, Pancheng, Sachs, Matthew S, Liu, Yi
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 26.09.2019
• Subjects: Amino Acid Sequence - genetics; Animals; Codon, Nonsense - genetics; Codon, Terminator - genetics; Drosophila - genetics; Drosophila Proteins - genetics; Molecular Biology; Neurospora - genetics; Peptide Termination Factors - genetics; Protein Biosynthesis; Ribosomes - genetics; RNA, Messenger - genetics

Codon usage bias is a universal feature of eukaryotic and prokaryotic genomes and plays an important role in regulating gene expression levels. A major role of codon usage is thought to regulate protein expression levels by affecting mRNA translation efficiency, but the underlying mechanism is uncle...