Association of common copy number variants at the glutathione S-transferase genes and rare novel genomic changes with schizophrenia
Copy number variants (CNVs) are a substantial source of human genetic diversity, influencing the variable susceptibility to multifactorial disorders. Schizophrenia is a complex illness thought to be caused by a number of genetic and environmental effects, few of which have been clearly defined. Rece...
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Published in | Molecular psychiatry Vol. 15; no. 10; pp. 1023 - 1033 |
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Main Authors | , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
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London
Nature Publishing Group UK
01.10.2010
Nature Publishing Group |
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Abstract | Copy number variants (CNVs) are a substantial source of human genetic diversity, influencing the variable susceptibility to multifactorial disorders. Schizophrenia is a complex illness thought to be caused by a number of genetic and environmental effects, few of which have been clearly defined. Recent reports have found several low prevalent CNVs associated with the disease. We have used a multiplex ligation-dependent probe amplification-based (MLPA) method to target 140 previously reported and putatively relevant gene-containing CNV regions in 654 schizophrenic patients and 604 controls for association studies. Most genotyped CNVs (95%) showed very low (<1%) population frequency. A few novel rare variants were only present in patients suggesting a possible pathogenic involvement, including 1.39 Mb overlapping duplications at 22q11.23 found in two unrelated patients, and duplications of the somatostatin receptor 5 gene (
SSTR5)
at 16p13.3 in three unrelated patients. Furthermore, among the few relatively common CNVs observed in patients and controls, the combined analysis of gene copy number genotypes at two glutathione
S
-transferase (GST) genes,
GSTM1
(glutathione
S
-transferase mu 1) (1p13.3) and
GSTT2
(glutathione
S
-transferase theta 2) (22q11.23), showed a statistically significant association of non-null genotypes at both loci with an additive effect for increased vulnerability to schizophrenia (odds ratio of 1.92;
P
=0.0008). Our data provide complementary evidences for low prevalent, but highly penetrant chromosomal variants associated with schizophrenia, as well as for common CNVs that may act as susceptibility factors by disturbing glutathione metabolism. |
---|---|
AbstractList | Copy number variants (CNVs) are a substantial source of human genetic diversity, influencing the variable susceptibility to multifactorial disorders. Schizophrenia is a complex illness thought to be caused by a number of genetic and environmental effects, few of which have been clearly defined. Recent reports have found several low prevalent CNVs associated with the disease. We have used a multiplex ligation-dependent probe amplification-based (MLPA) method to target 140 previously reported and putatively relevant gene-containing CNV regions in 654 schizophrenic patients and 604 controls for association studies. Most genotyped CNVs (95%) showed very low (<1%) population frequency. A few novel rare variants were only present in patients suggesting a possible pathogenic involvement, including 1.39 Mb overlapping duplications at 22q11.23 found in two unrelated patients, and duplications of the somatostatin receptor 5 gene (SSTR5) at 16p13.3 in three unrelated patients. Furthermore, among the few relatively common CNVs observed in patients and controls, the combined analysis of gene copy number genotypes at two glutathione S-transferase (GST) genes, GSTM1 (glutathione S-transferase mu 1) (1p13.3) and GSTT2 (glutathione S-transferase theta 2) (22q11.23), showed a statistically significant association of non-null genotypes at both loci with an additive effect for increased vulnerability to schizophrenia (odds ratio of 1.92; P=0.0008). Our data provide complementary evidences for low prevalent, but highly penetrant chromosomal variants associated with schizophrenia, as well as for common CNVs that may act as susceptibility factors by disturbing glutathione metabolism. Copy number variants (CNVs) are a substantial source of human genetic diversity, influencing the variable susceptibility to multifactorial disorders. Schizophrenia is a complex illness thought to be caused by a number of genetic and environmental effects, few of which have been clearly defined. Recent reports have found several low prevalent CNVs associated with the disease. We have used a multiplex ligation-dependent probe amplification-based (MLPA) method to target 140 previously reported and putatively relevant gene-containing CNV regions in 654 schizophrenic patients and 604 controls for association studies. Most genotyped CNVs (95%) showed very low (<1%) population frequency. A few novel rare variants were only present in patients suggesting a possible pathogenic involvement, including 1.39 Mb overlapping duplications at 22q11.23 found in two unrelated patients, and duplications of the somatostatin receptor 5 gene (SSTR5) at 16p13.3 in three unrelated patients. Furthermore, among the few relatively common CNVs observed in patients and controls, the combined analysis of gene copy number genotypes at two glutathione S-transferase (GST) genes, GSTM1 (glutathione S-transferase mu 1) (1p13.3) and GSTT2(glutathione S-transferase theta 2) (22q11.23), showed a statistically significant association of non-null genotypes at both loci with an additive effect for increased vulnerability to schizophrenia (odds ratio of 1.92; P =0.0008). Our data provide complementary evidences for low prevalent, but highly penetrant chromosomal variants associated with schizophrenia, as well as for common CNVs that may act as susceptibility factors by disturbing glutathione metabolism. Molecular Psychiatry (2010) 15, 1023-1033; doi: 10.1038/mp.2009.53; published online 16 June 2009 Keywords: structural variation; copy number variant; 22q11.23 duplication; genetic predisposition to disease; glutathione transferase/genetics Copy number variants (CNVs) are a substantial source of human genetic diversity, influencing the variable susceptibility to multifactorial disorders. Schizophrenia is a complex illness thought to be caused by a number of genetic and environmental effects, few of which have been clearly defined. Recent reports have found several low prevalent CNVs associated with the disease. We have used a multiplex ligation-dependent probe amplification-based (MLPA) method to target 140 previously reported and putatively relevant gene-containing CNV regions in 654 schizophrenic patients and 604 controls for association studies. Most genotyped CNVs (95%) showed very low (<1%) population frequency. A few novel rare variants were only present in patients suggesting a possible pathogenic involvement, including 1.39Mb overlapping duplications at 22q11.23 found in two unrelated patients, and duplications of the somatostatin receptor 5 gene (SSTR5) at 16p13.3 in three unrelated patients. Furthermore, among the few relatively common CNVs observed in patients and controls, the combined analysis of gene copy number genotypes at two glutathione S-transferase (GST) genes, GSTM1 (glutathione S-transferase mu 1) (1p13.3) and GSTT2 (glutathione S-transferase theta 2) (22q11.23), showed a statistically significant association of non-null genotypes at both loci with an additive effect for increased vulnerability to schizophrenia (odds ratio of 1.92; P=0.0008). Our data provide complementary evidences for low prevalent, but highly penetrant chromosomal variants associated with schizophrenia, as well as for common CNVs that may act as susceptibility factors by disturbing glutathione metabolism. Copy number variants (CNVs) are a substantial source of human genetic diversity, influencing the variable susceptibility to multifactorial disorders. Schizophrenia is a complex illness thought to be caused by a number of genetic and environmental effects, few of which have been clearly defined. Recent reports have found several low prevalent CNVs associated with the disease. We have used a multiplex ligation-dependent probe amplification-based (MLPA) method to target 140 previously reported and putatively relevant gene-containing CNV regions in 654 schizophrenic patients and 604 controls for association studies. Most genotyped CNVs (95%) showed very low (<1%) population frequency. A few novel rare variants were only present in patients suggesting a possible pathogenic involvement, including 1.39 Mb overlapping duplications at 22q11.23 found in two unrelated patients, and duplications of the somatostatin receptor 5 gene (SSTR5) at 16p13.3 in three unrelated patients. Furthermore, among the few relatively common CNVs observed in patients and controls, the combined analysis of gene copy number genotypes at two glutathione S-transferase (GST) genes, GSTM1 (glutathione S-transferase mu 1) (1p13.3) and GSTT2 (glutathione S-transferase theta 2) (22q11.23), showed a statistically significant association of non-null genotypes at both loci with an additive effect for increased vulnerability to schizophrenia (odds ratio of 1.92; P=0.0008). Our data provide complementary evidences for low prevalent, but highly penetrant chromosomal variants associated with schizophrenia, as well as for common CNVs that may act as susceptibility factors by disturbing glutathione metabolism. Copy number variants (CNVs) are a substantial source of human genetic diversity, influencing the variable susceptibility to multifactorial disorders. Schizophrenia is a complex illness thought to be caused by a number of genetic and environmental effects, few of which have been clearly defined. Recent reports have found several low prevalent CNVs associated with the disease. We have used a multiplex ligation-dependent probe amplification-based (MLPA) method to target 140 previously reported and putatively relevant gene-containing CNV regions in 654 schizophrenic patients and 604 controls for association studies. Most genotyped CNVs (95%) showed very low (<1%) population frequency. A few novel rare variants were only present in patients suggesting a possible pathogenic involvement, including 1.39 Mb overlapping duplications at 22q11.23 found in two unrelated patients, and duplications of the somatostatin receptor 5 gene ( SSTR5) at 16p13.3 in three unrelated patients. Furthermore, among the few relatively common CNVs observed in patients and controls, the combined analysis of gene copy number genotypes at two glutathione S -transferase (GST) genes, GSTM1 (glutathione S -transferase mu 1) (1p13.3) and GSTT2 (glutathione S -transferase theta 2) (22q11.23), showed a statistically significant association of non-null genotypes at both loci with an additive effect for increased vulnerability to schizophrenia (odds ratio of 1.92; P =0.0008). Our data provide complementary evidences for low prevalent, but highly penetrant chromosomal variants associated with schizophrenia, as well as for common CNVs that may act as susceptibility factors by disturbing glutathione metabolism. |
Audience | Academic |
Author | Rodríguez-Santiago, B Carracedo, A Estivill, X Gabau, E Gutiérrez-Zotes, A Vilella, E Brunet, A Labad, A Pérez-Jurado, L A Flores, R Sobrino, B Guillamat, R Valero, J Armengol, Ll Guitart, M Serra-Juhé, C Martorell, L |
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BackLink | https://www.ncbi.nlm.nih.gov/pubmed/19528963$$D View this record in MEDLINE/PubMed |
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Cites_doi | 10.1074/jbc.C000429200 10.1093/hmg/ddm323 10.1016/j.schres.2007.07.029 10.1126/science.1101160 10.1002/ajmg.b.30273 10.1136/jmg.40.12.907 10.1038/ng2054 10.1385/JMN:26:2-3:209 10.1016/j.parkreldis.2004.02.014 10.1038/nature07239 10.1093/hmg/ddl468 10.1002/ajmg.b.30703 10.1046/j.1471-4159.1999.0730889.x 10.1016/j.ygeno.2006.10.001 10.1126/science.1155174 10.1002/humu.20072 10.1086/344514 10.1192/bjp.bp.106.025585 10.1038/sj.mp.4001049 10.1086/507566 10.1002/ajmg.1320420131 10.1038/sj.mp.4000825 10.1016/j.nlm.2006.05.004 10.1038/nature04489 10.1038/sj.mp.4002049 10.1086/376578 10.1038/nature07229 10.1007/s11064-007-9315-z 10.1016/j.gde.2007.08.009 10.1038/ng1862 10.1001/archpsyc.56.10.940 10.1046/j.1460-9568.2000.00229.x 10.1146/annurev.genom.7.080505.115618 10.1038/nature05329 10.1046/j.1432-1327.2000.01595.x 10.1097/YCO.0b013e3282f4efde 10.1146/annurev.genom.3.032802.120023 10.1038/nrg1767 10.1136/jmg.40.5.325 10.1093/nar/gnf056 10.1074/jbc.M212969200 10.1097/00001756-200303030-00003 10.1101/gr.073197.107 10.2217/14622416.7.1.25 10.1002/humu.20054 10.1371/journal.pone.0001944 10.1097/00041444-200409000-00005 10.1016/j.psychres.2006.03.024 10.1038/sj.mp.4001232 10.1016/j.bbrc.2006.03.156 10.1086/376549 10.1086/505915 10.1093/hmg/ddi489 10.1038/ng1416 10.1101/gr.6861907 10.1186/1471-2164-4-15 10.1186/1471-2350-9-27 10.1006/bbrc.2001.4347 10.1124/pr.55.3.2 10.1016/j.schres.2005.03.023 10.1126/science.1112915 10.1038/nature07458 10.1124/mol.104.003376 10.1038/ng.162 10.1176/appi.ajp.163.3.529 10.1002/ajmg.b.30902 |
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References | Lai, Luo, Burnett, Hong, Snyder (CR37) 2000; 275 Bray, Buckland, Williams, Williams, Norton, Owen (CR63) 2003; 73 Wilson, Flibotte, Chopra, Melnyk, Honer, Holt (CR17) 2006; 15 McClellan, Susser, King (CR68) 2007; 190 White, Vink, Kriek, Wuyts, Schouten, Bakker (CR29) 2004; 24 Saito, Guan, Papolos, Rajouria, Fann, Lachman (CR43) 2001; 6 Matsuzawa, Obata, Shirayama, Nonaka, Kanazawa, Yoshitome (CR55) 2008; 3 Friedman, Vrijenhoek, Markx, Janssen, van der Vliet, Faas (CR20) 2008; 13 Aitman, Dong, Vyse, Norsworthy, Johnson, Smith (CR7) 2006; 439 Kirov, Gumus, Chen, Norton, Georgieva, Sari (CR21) 2008; 17 Feuk, Carson, Scherer (CR3) 2006; 7 Cook, Scherer (CR10) 2008; 455 Lencz, Robinson, Xu, Ekholm, Sevy, Gunduz-Bruce (CR48) 2006; 163 Saadat, Mobayen, Farrashbandi (CR56) 2007; 153 Agnati, Ferre, Lluis, Franco, Fuxe (CR45) 2003; 55 Harada, Tachikawa, Kawanishi (CR53) 2001; 281 Slater, Bruno, Ren, Pertile, Schouten, Choo (CR32) 2003; 40 Xu, Roos, Levy, van Rensburg, Gogos, Karayiorgou (CR22) 2008; 40 Sharp, Hansen, Selzer, Cheng, Regan, Hurst (CR49) 2006; 38 Janaky, Dohovics, Saransaari, Oja (CR58) 2007; 32 Gonzalez, Kulkarni, Bolivar, Mangano, Sanchez, Catano (CR9) 2005; 307 Fuxe, Ferre, Canals, Torvinen, Terasmaa, Marcellino (CR40) 2005; 26 Yin, Haynie, Williams, Yang (CR51) 2003; 278 Moon, Yim, Lee, Jeon, Kim, Ko (CR19) 2006; 344 Gimenez-Llort, Schiffmann, Shmidt, Canela, Camon, Wassholm (CR38) 2007; 87 Torvinen, Marcellino, Canals, Agnati, Lluis, Franco (CR41) 2005; 67 Schulz, Lindenau, Seyfried, Dichgans (CR67) 2000; 267 Glatt, Jonsson (CR47) 2006; 141B Wonodi, Hong, Avila, Buchanan, Carpenter, Stine (CR44) 2005; 78 Murphy, Jones, Owen (CR12) 1999; 56 Carlson, Papolos, Pandita, Faedda, Veit, Goldberg (CR11) 1997; 60 Stefansson, Rujescu, Cichon, Pietilainen, Ingason, Steinberg (CR24) 2008; 455 Schouten, McElgunn, Waaijer, Zwijnenburg, Diepvens, Pals (CR30) 2002; 30 Sutrala, Goossens, Williams, Heyrman, Adolfsson, Norton (CR18) 2007; 96 Deckert, Brenner, Durany, Zochling, Paulus, Ransmayr (CR42) 2003; 14 Fellermann, Stange, Schaeffeler, Schmalzl, Wehkamp, Bevins (CR8) 2006; 79 Lewis, Levinson, Wise, DeLisi, Straub, Hovatta (CR62) 2003; 73 Do, Trabesinger, Kirsten-Kruger, Lauer, Dydak, Hell (CR59) 2000; 12 Cusco, Corominas, Bayes, Flores, Rivera-Brugues, Campuzano (CR28) 2008; 18 Ferre, Ciruela, Canals, Marcellino, Burgueno, Casado (CR39) 2004; 10 Ouahchi, Lindeman, Lee (CR6) 2006; 7 Cooper, Nickerson, Eichler (CR4) 2007; 39 Cusco, Del Campo, Vilardell, Gonzalez, Gener, Galan (CR33) 2008; 9 Sullivan (CR36) 2008; 21 Hebbring, Adjei, Baer, Jenkins, Zhang, Cunningham (CR5) 2007; 16 Iafrate, Feuk, Rivera, Listewnik, Donahoe, Qi (CR27) 2004; 36 Millar, Pickard, Mackie, James, Christie, Buchanan (CR15) 2005; 310 Nyegaard, Borglum, Bruun, Collier, Russ, Mors (CR46) 2002; 7 Kamnasaran, Muir, Ferguson-Smith, Cox (CR16) 2003; 40 Shifman, Bronstein, Sternfeld, Pisante-Shalom, Lev-Lehman, Weizman (CR65) 2002; 71 Hashimoto, Hashimoto, Miyatake, Matsuzawa, Sekine, Shimizu (CR52) 2008; 147B Inoue, Lupski (CR2) 2002; 3 Slater, Bruno, Ren, La, Burgess, Hills (CR31) 2004; 24 Janaky, Ogita, Pasqualotto, Bains, Oja, Yoneda (CR60) 1999; 73 Tosic, Ott, Barral, Bovet, Deppen, Gheorghita (CR57) 2006; 79 Wang, Li, Hadley, Liu, Glessner, Grant (CR34) 2007; 17 CR26 Sutcliffe, Han, Amin, Kesterson, Nurmi (CR50) 2003; 4 Sharp, Cheng, Eichler (CR1) 2006; 7 Shaw (CR61) 1998 Walsh, McClellan, McCarthy, Addington, Pierce, Cooper (CR25) 2008; 320 Pae, Yu, Kim, Kim, Lee, Lee (CR54) 2004; 14 Stone, O'Donovan, Gurling, Kirov, Blackwood, Corvin (CR23) 2008; 455 Reymond, Henrichsen, Harewood, Merla (CR66) 2007; 17 Bulayeva, Glatt, Bulayev, Pavlova, Tsuang (CR64) 2007; 89 Shprintzen, Goldberg, Golding-Kushner, Marion (CR13) 1992; 42 MacIntyre, Blackwood, Porteous, Pickard, Muir (CR14) 2003; 8 Redon, Ishikawa, Fitch, Feuk, Perry, Andrews (CR35) 2006; 444 S Harada (BFmp200953_CR53) 2001; 281 KC Murphy (BFmp200953_CR12) 1999; 56 T Hashimoto (BFmp200953_CR52) 2008; 147B JB Schulz (BFmp200953_CR67) 2000; 267 M Nyegaard (BFmp200953_CR46) 2002; 7 R Janaky (BFmp200953_CR60) 1999; 73 I Wonodi (BFmp200953_CR44) 2005; 78 L Feuk (BFmp200953_CR3) 2006; 7 GM Wilson (BFmp200953_CR17) 2006; 15 K Fuxe (BFmp200953_CR40) 2005; 26 H Slater (BFmp200953_CR31) 2004; 24 T Lencz (BFmp200953_CR48) 2006; 163 AJ Sharp (BFmp200953_CR1) 2006; 7 Z Yin (BFmp200953_CR51) 2003; 278 JK Millar (BFmp200953_CR15) 2005; 310 NJ Bray (BFmp200953_CR63) 2003; 73 HR Slater (BFmp200953_CR32) 2003; 40 K Fellermann (BFmp200953_CR8) 2006; 79 E Gonzalez (BFmp200953_CR9) 2005; 307 M Saadat (BFmp200953_CR56) 2007; 153 I Cusco (BFmp200953_CR33) 2008; 9 BFmp200953_CR26 JS Sutcliffe (BFmp200953_CR50) 2003; 4 JL Stone (BFmp200953_CR23) 2008; 455 J Deckert (BFmp200953_CR42) 2003; 14 K Inoue (BFmp200953_CR2) 2002; 3 R Janaky (BFmp200953_CR58) 2007; 32 M Torvinen (BFmp200953_CR41) 2005; 67 S Shifman (BFmp200953_CR65) 2002; 71 D Kamnasaran (BFmp200953_CR16) 2003; 40 PF Sullivan (BFmp200953_CR36) 2008; 21 SJ Glatt (BFmp200953_CR47) 2006; 141B D Matsuzawa (BFmp200953_CR55) 2008; 3 EH Cook Jr (BFmp200953_CR10) 2008; 455 M Tosic (BFmp200953_CR57) 2006; 79 I Cusco (BFmp200953_CR28) 2008; 18 KB Bulayeva (BFmp200953_CR64) 2007; 89 G Kirov (BFmp200953_CR21) 2008; 17 L Gimenez-Llort (BFmp200953_CR38) 2007; 87 H Stefansson (BFmp200953_CR24) 2008; 455 B Xu (BFmp200953_CR22) 2008; 40 LF Agnati (BFmp200953_CR45) 2003; 55 CM Lewis (BFmp200953_CR62) 2003; 73 C Shaw (BFmp200953_CR61) 1998 K Ouahchi (BFmp200953_CR6) 2006; 7 CU Pae (BFmp200953_CR54) 2004; 14 R Redon (BFmp200953_CR35) 2006; 444 TJ Aitman (BFmp200953_CR7) 2006; 439 SR Sutrala (BFmp200953_CR18) 2007; 96 AJ Iafrate (BFmp200953_CR27) 2004; 36 SJ White (BFmp200953_CR29) 2004; 24 T Saito (BFmp200953_CR43) 2001; 6 KQ Do (BFmp200953_CR59) 2000; 12 MM Lai (BFmp200953_CR37) 2000; 275 DJ MacIntyre (BFmp200953_CR14) 2003; 8 AJ Sharp (BFmp200953_CR49) 2006; 38 S Ferre (BFmp200953_CR39) 2004; 10 T Walsh (BFmp200953_CR25) 2008; 320 GM Cooper (BFmp200953_CR4) 2007; 39 JP Schouten (BFmp200953_CR30) 2002; 30 HJ Moon (BFmp200953_CR19) 2006; 344 C Carlson (BFmp200953_CR11) 1997; 60 JI Friedman (BFmp200953_CR20) 2008; 13 A Reymond (BFmp200953_CR66) 2007; 17 JM McClellan (BFmp200953_CR68) 2007; 190 RJ Shprintzen (BFmp200953_CR13) 1992; 42 SJ Hebbring (BFmp200953_CR5) 2007; 16 K Wang (BFmp200953_CR34) 2007; 17 |
References_xml | – volume: 275 start-page: 34017 year: 2000 end-page: 34020 ident: CR37 article-title: The calcineurin-binding protein cain is a negative regulator of synaptic vesicle endocytosis publication-title: J Biol Chem doi: 10.1074/jbc.C000429200 contributor: fullname: Snyder – volume: 17 start-page: 458 year: 2008 end-page: 465 ident: CR21 article-title: Comparative genome hybridization suggests a role for NRXN1 and APBA2 in schizophrenia publication-title: Hum Mol Genet doi: 10.1093/hmg/ddm323 contributor: fullname: Sari – volume: 96 start-page: 93 year: 2007 end-page: 99 ident: CR18 article-title: Gene copy number variation in schizophrenia publication-title: Schizophr Res doi: 10.1016/j.schres.2007.07.029 contributor: fullname: Norton – volume: 307 start-page: 1434 year: 2005 end-page: 1440 ident: CR9 article-title: The influence of CCL3L1 gene-containing segmental duplications on HIV-1/AIDS susceptibility publication-title: Science (New York, NY) doi: 10.1126/science.1101160 contributor: fullname: Catano – volume: 141B start-page: 149 year: 2006 end-page: 154 ident: CR47 article-title: The Cys allele of the DRD2 Ser311Cys polymorphism has a dominant effect on risk for schizophrenia: evidence from fixed- and random-effects meta-analyses publication-title: Am J Med Genet B Neuropsychiatr Genet doi: 10.1002/ajmg.b.30273 contributor: fullname: Jonsson – volume: 40 start-page: 907 year: 2003 end-page: 912 ident: CR32 article-title: Rapid, high throughput prenatal detection of aneuploidy using a novel quantitative method (MLPA) publication-title: J Med Genet doi: 10.1136/jmg.40.12.907 contributor: fullname: Choo – volume: 39 start-page: S22 issue: 7 Suppl year: 2007 end-page: S29 ident: CR4 article-title: Mutational and selective effects on copy-number variants in the human genome publication-title: Nat Genet doi: 10.1038/ng2054 contributor: fullname: Eichler – volume: 26 start-page: 209 year: 2005 end-page: 220 ident: CR40 article-title: Adenosine A2A and dopamine D2 heteromeric receptor complexes and their function publication-title: J Mol Neurosci doi: 10.1385/JMN:26:2-3:209 contributor: fullname: Marcellino – volume: 10 start-page: 265 year: 2004 end-page: 271 ident: CR39 article-title: Adenosine A2A-dopamine D2 receptor-receptor heteromers. Targets for neuro-psychiatric disorders publication-title: Parkinsonism Relat Disord doi: 10.1016/j.parkreldis.2004.02.014 contributor: fullname: Casado – volume: 455 start-page: 237 year: 2008 end-page: 241 ident: CR23 article-title: Rare chromosomal deletions and duplications increase risk of schizophrenia publication-title: Nature doi: 10.1038/nature07239 contributor: fullname: Corvin – volume: 16 start-page: 463 year: 2007 end-page: 470 ident: CR5 article-title: Human SULT1A1 gene: copy number differences and functional implications publication-title: Hum Mol Genet doi: 10.1093/hmg/ddl468 contributor: fullname: Cunningham – volume: 147B start-page: 1040 year: 2008 end-page: 1046 ident: CR52 article-title: Association study between the genetic polymorphisms of glutathione-related enzymes and schizophrenia in a Japanese population publication-title: Am J Med Genet B Neuropsychiatr Genet doi: 10.1002/ajmg.b.30703 contributor: fullname: Shimizu – volume: 73 start-page: 889 year: 1999 end-page: 902 ident: CR60 article-title: Glutathione and signal transduction in the mammalian CNS publication-title: J Neurochem doi: 10.1046/j.1471-4159.1999.0730889.x contributor: fullname: Yoneda – volume: 89 start-page: 167 year: 2007 end-page: 177 ident: CR64 article-title: Genome-wide linkage scan of schizophrenia: a cross-isolate study publication-title: Genomics doi: 10.1016/j.ygeno.2006.10.001 contributor: fullname: Tsuang – volume: 320 start-page: 539 year: 2008 end-page: 543 ident: CR25 article-title: Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia publication-title: Science (New York, NY) doi: 10.1126/science.1155174 contributor: fullname: Cooper – volume: 24 start-page: 164 year: 2004 end-page: 171 ident: CR31 article-title: Improved testing for CMT1A and HNPP using multiplex ligation-dependent probe amplification (MLPA) with rapid DNA preparations: comparison with the interphase FISH method publication-title: Hum Mutat doi: 10.1002/humu.20072 contributor: fullname: Hills – volume: 71 start-page: 1296 year: 2002 end-page: 1302 ident: CR65 article-title: A highly significant association between a COMT haplotype and schizophrenia publication-title: Am J Hum Genet doi: 10.1086/344514 contributor: fullname: Weizman – volume: 190 start-page: 194 year: 2007 end-page: 199 ident: CR68 article-title: Schizophrenia: a common disease caused by multiple rare alleles publication-title: Br J Psychiatry doi: 10.1192/bjp.bp.106.025585 contributor: fullname: King – volume: 7 start-page: 745 year: 2002 end-page: 754 ident: CR46 article-title: Novel polymorphisms in the somatostatin receptor 5 (SSTR5) gene associated with bipolar affective disorder publication-title: Mol Psychiatry doi: 10.1038/sj.mp.4001049 contributor: fullname: Mors – volume: 79 start-page: 586 year: 2006 end-page: 592 ident: CR57 article-title: Schizophrenia and oxidative stress: glutamate cysteine ligase modifier as a susceptibility gene publication-title: Am J Hum Genet doi: 10.1086/507566 contributor: fullname: Gheorghita – volume: 42 start-page: 141 year: 1992 end-page: 142 ident: CR13 article-title: Late-onset psychosis in the velo-cardio-facial syndrome publication-title: Am J Med Genet doi: 10.1002/ajmg.1320420131 contributor: fullname: Marion – volume: 6 start-page: 193 year: 2001 end-page: 201 ident: CR43 article-title: Polymorphism in SNAP29 gene promoter region associated with schizophrenia publication-title: Mol Psychiatry doi: 10.1038/sj.mp.4000825 contributor: fullname: Lachman – volume: 87 start-page: 42 year: 2007 end-page: 56 ident: CR38 article-title: Working memory deficits in transgenic rats overexpressing human adenosine A2A receptors in the brain publication-title: Neurobiol Learn Mem doi: 10.1016/j.nlm.2006.05.004 contributor: fullname: Wassholm – volume: 439 start-page: 851 year: 2006 end-page: 855 ident: CR7 article-title: Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans publication-title: Nature doi: 10.1038/nature04489 contributor: fullname: Smith – volume: 13 start-page: 261 year: 2008 end-page: 266 ident: CR20 article-title: CNTNAP2 gene dosage variation is associated with schizophrenia and epilepsy publication-title: Mol Psychiatry doi: 10.1038/sj.mp.4002049 contributor: fullname: Faas – volume: 73 start-page: 152 year: 2003 end-page: 161 ident: CR63 article-title: A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain publication-title: Am J Hum Genet doi: 10.1086/376578 contributor: fullname: Owen – volume: 60 start-page: 851 year: 1997 end-page: 859 ident: CR11 article-title: Molecular analysis of velo-cardio-facial syndrome patients with psychiatric disorders publication-title: Am J Hum Genet contributor: fullname: Goldberg – volume: 455 start-page: 232 year: 2008 end-page: 236 ident: CR24 article-title: Large recurrent microdeletions associated with schizophrenia publication-title: Nature doi: 10.1038/nature07229 contributor: fullname: Steinberg – volume: 32 start-page: 1357 year: 2007 end-page: 1364 ident: CR58 article-title: Modulation of [3H]dopamine release by glutathione in mouse striatal slices publication-title: Neurochem Res doi: 10.1007/s11064-007-9315-z contributor: fullname: Oja – ident: CR26 – volume: 17 start-page: 381 year: 2007 end-page: 386 ident: CR66 article-title: Side effects of genome structural changes publication-title: Curr Opin Genet Dev doi: 10.1016/j.gde.2007.08.009 contributor: fullname: Merla – volume: 38 start-page: 1038 year: 2006 end-page: 1042 ident: CR49 article-title: Discovery of previously unidentified genomic disorders from the duplication architecture of the human genome publication-title: Nat Genet doi: 10.1038/ng1862 contributor: fullname: Hurst – start-page: 3 year: 1998 end-page: 23 ident: CR61 article-title: Multiple roles of glutathione in the nervous system publication-title: Glutathione in the Nervous System contributor: fullname: Shaw – volume: 56 start-page: 940 year: 1999 end-page: 945 ident: CR12 article-title: High rates of schizophrenia in adults with velo-cardio-facial syndrome publication-title: Arch Gen Psychiatry doi: 10.1001/archpsyc.56.10.940 contributor: fullname: Owen – volume: 12 start-page: 3721 year: 2000 end-page: 3728 ident: CR59 article-title: Schizophrenia: glutathione deficit in cerebrospinal fluid and prefrontal cortex publication-title: Eur J Neurosci doi: 10.1046/j.1460-9568.2000.00229.x contributor: fullname: Hell – volume: 7 start-page: 407 year: 2006 end-page: 442 ident: CR1 article-title: Structural variation of the human genome publication-title: Annu Rev Genomics Hum Genet doi: 10.1146/annurev.genom.7.080505.115618 contributor: fullname: Eichler – volume: 444 start-page: 444 year: 2006 end-page: 454 ident: CR35 article-title: Global variation in copy number in the human genome publication-title: Nature doi: 10.1038/nature05329 contributor: fullname: Andrews – volume: 267 start-page: 4904 year: 2000 end-page: 4911 ident: CR67 article-title: Glutathione, oxidative stress and neurodegeneration publication-title: Eur J Biochem doi: 10.1046/j.1432-1327.2000.01595.x contributor: fullname: Dichgans – volume: 21 start-page: 157 year: 2008 end-page: 160 ident: CR36 article-title: Schizophrenia genetics: the search for a hard lead publication-title: Curr Opin Psychiatry doi: 10.1097/YCO.0b013e3282f4efde contributor: fullname: Sullivan – volume: 3 start-page: 199 year: 2002 end-page: 242 ident: CR2 article-title: Molecular mechanisms for genomic disorders publication-title: Annu Rev Genomics Hum Genet doi: 10.1146/annurev.genom.3.032802.120023 contributor: fullname: Lupski – volume: 7 start-page: 85 year: 2006 end-page: 97 ident: CR3 article-title: Structural variation in the human genome publication-title: Nat Rev Genet doi: 10.1038/nrg1767 contributor: fullname: Scherer – volume: 40 start-page: 325 year: 2003 end-page: 332 ident: CR16 article-title: Disruption of the neuronal PAS3 gene in a family affected with schizophrenia publication-title: J Med Genet doi: 10.1136/jmg.40.5.325 contributor: fullname: Cox – volume: 30 start-page: e57 year: 2002 ident: CR30 article-title: Relative quantification of 40 nucleic acid sequences by multiplex ligation-dependent probe amplification publication-title: Nucleic Acids Res doi: 10.1093/nar/gnf056 contributor: fullname: Pals – volume: 278 start-page: 22838 year: 2003 end-page: 22845 ident: CR51 article-title: C114 is a novel IL-11-inducible nuclear double-stranded RNA-binding protein that inhibits protein kinase R publication-title: J Biol Chem doi: 10.1074/jbc.M212969200 contributor: fullname: Yang – volume: 14 start-page: 313 year: 2003 end-page: 316 ident: CR42 article-title: Up-regulation of striatal adenosine A(2A) receptors in schizophrenia publication-title: Neuroreport doi: 10.1097/00001756-200303030-00003 contributor: fullname: Ransmayr – volume: 18 start-page: 683 year: 2008 end-page: 694 ident: CR28 article-title: Copy number variation at the 7q11.23 segmental duplications is a susceptibility factor for the Williams-Beuren syndrome deletion publication-title: Genome Res doi: 10.1101/gr.073197.107 contributor: fullname: Campuzano – volume: 7 start-page: 25 year: 2006 end-page: 29 ident: CR6 article-title: Copy number variants and pharmacogenomics publication-title: Pharmacogenomics doi: 10.2217/14622416.7.1.25 contributor: fullname: Lee – volume: 24 start-page: 86 year: 2004 end-page: 92 ident: CR29 article-title: Two-color multiplex ligation-dependent probe amplification: detecting genomic rearrangements in hereditary multiple exostoses publication-title: Hum Mutat doi: 10.1002/humu.20054 contributor: fullname: Bakker – volume: 3 start-page: e1944 year: 2008 ident: CR55 article-title: Negative correlation between brain glutathione level and negative symptoms in schizophrenia: a 3T 1H-MRS study publication-title: PLoS ONE doi: 10.1371/journal.pone.0001944 contributor: fullname: Yoshitome – volume: 14 start-page: 147 year: 2004 end-page: 150 ident: CR54 article-title: Glutathione S-transferase M1 polymorphism may contribute to schizophrenia in the Korean population publication-title: Psychiatr Genet doi: 10.1097/00041444-200409000-00005 contributor: fullname: Lee – volume: 153 start-page: 87 year: 2007 end-page: 91 ident: CR56 article-title: Genetic polymorphism of glutathione S-transferase T1: a candidate genetic modifier of individual susceptibility to schizophrenia publication-title: Psychiatry Res doi: 10.1016/j.psychres.2006.03.024 contributor: fullname: Farrashbandi – volume: 8 start-page: 275 year: 2003 end-page: 287 ident: CR14 article-title: Chromosomal abnormalities and mental illness publication-title: Mol Psychiatry doi: 10.1038/sj.mp.4001232 contributor: fullname: Muir – volume: 344 start-page: 531 year: 2006 end-page: 539 ident: CR19 article-title: Identification of DNA copy-number aberrations by array-comparative genomic hybridization in patients with schizophrenia publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2006.03.156 contributor: fullname: Ko – volume: 73 start-page: 34 year: 2003 end-page: 48 ident: CR62 article-title: Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: schizophrenia publication-title: Am J Hum Genet doi: 10.1086/376549 contributor: fullname: Hovatta – volume: 79 start-page: 439 year: 2006 end-page: 448 ident: CR8 article-title: A chromosome 8 gene-cluster polymorphism with low human beta-defensin 2 gene copy number predisposes to Crohn disease of the colon publication-title: Am J Hum Genet doi: 10.1086/505915 contributor: fullname: Bevins – volume: 15 start-page: 743 year: 2006 end-page: 749 ident: CR17 article-title: DNA copy-number analysis in bipolar disorder and schizophrenia reveals aberrations in genes involved in glutamate signaling publication-title: Hum Mol Genet doi: 10.1093/hmg/ddi489 contributor: fullname: Holt – volume: 36 start-page: 949 year: 2004 end-page: 951 ident: CR27 article-title: Detection of large-scale variation in the human genome publication-title: Nat Genet doi: 10.1038/ng1416 contributor: fullname: Qi – volume: 17 start-page: 1665 year: 2007 end-page: 1674 ident: CR34 article-title: PennCNV: an integrated hidden Markov model designed for high-resolution copy number variation detection in whole-genome SNP genotyping data publication-title: Genome Res doi: 10.1101/gr.6861907 contributor: fullname: Grant – volume: 4 start-page: 15 year: 2003 ident: CR50 article-title: Partial duplication of the APBA2 gene in chromosome 15q13 corresponds to duplicon structures publication-title: BMC Genomics doi: 10.1186/1471-2164-4-15 contributor: fullname: Nurmi – volume: 9 start-page: 27 year: 2008 ident: CR33 article-title: Array-CGH in patients with Kabuki-like phenotype: Identification of two patients with complex rearrangements including 2q37 deletions and no other recurrent aberration publication-title: BMC Med Genet doi: 10.1186/1471-2350-9-27 contributor: fullname: Galan – volume: 281 start-page: 267 year: 2001 end-page: 271 ident: CR53 article-title: Glutathione S-transferase M1 gene deletion may be associated with susceptibility to certain forms of schizophrenia publication-title: Biochem Biophys Res Commun doi: 10.1006/bbrc.2001.4347 contributor: fullname: Kawanishi – volume: 55 start-page: 509 year: 2003 end-page: 550 ident: CR45 article-title: Molecular mechanisms and therapeutical implications of intramembrane receptor/receptor interactions among heptahelical receptors with examples from the striatopallidal GABA neurons publication-title: Pharmacol Rev doi: 10.1124/pr.55.3.2 contributor: fullname: Fuxe – volume: 78 start-page: 339 year: 2005 end-page: 341 ident: CR44 article-title: Association between polymorphism of the SNAP29 gene promoter region and schizophrenia publication-title: Schizophr Res doi: 10.1016/j.schres.2005.03.023 contributor: fullname: Stine – volume: 310 start-page: 1187 year: 2005 end-page: 1191 ident: CR15 article-title: DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling publication-title: Science (New York, NY) doi: 10.1126/science.1112915 contributor: fullname: Buchanan – volume: 455 start-page: 919 year: 2008 end-page: 923 ident: CR10 article-title: Copy-number variations associated with neuropsychiatric conditions publication-title: Nature doi: 10.1038/nature07458 contributor: fullname: Scherer – volume: 67 start-page: 400 year: 2005 end-page: 407 ident: CR41 article-title: Adenosine A2A receptor and dopamine D3 receptor interactions: evidence of functional A2A/D3 heteromeric complexes publication-title: Mol Pharmacol doi: 10.1124/mol.104.003376 contributor: fullname: Franco – volume: 40 start-page: 880 year: 2008 end-page: 885 ident: CR22 article-title: Strong association of copy number mutations with sporadic schizophrenia publication-title: Nat Genet doi: 10.1038/ng.162 contributor: fullname: Karayiorgou – volume: 163 start-page: 529 year: 2006 end-page: 531 ident: CR48 article-title: DRD2 promoter region variation as a predictor of sustained response to antipsychotic medication in first-episode schizophrenia patients publication-title: Am J Psychiatry doi: 10.1176/appi.ajp.163.3.529 contributor: fullname: Gunduz-Bruce – volume: 190 start-page: 194 year: 2007 ident: BFmp200953_CR68 publication-title: Br J Psychiatry doi: 10.1192/bjp.bp.106.025585 contributor: fullname: JM McClellan – volume: 42 start-page: 141 year: 1992 ident: BFmp200953_CR13 publication-title: Am J Med Genet doi: 10.1002/ajmg.1320420131 contributor: fullname: RJ Shprintzen – volume: 73 start-page: 152 year: 2003 ident: BFmp200953_CR63 publication-title: Am J Hum Genet doi: 10.1086/376578 contributor: fullname: NJ Bray – volume: 3 start-page: 199 year: 2002 ident: BFmp200953_CR2 publication-title: Annu Rev Genomics Hum Genet doi: 10.1146/annurev.genom.3.032802.120023 contributor: fullname: K Inoue – volume: 153 start-page: 87 year: 2007 ident: BFmp200953_CR56 publication-title: Psychiatry Res doi: 10.1016/j.psychres.2006.03.024 contributor: fullname: M Saadat – volume: 13 start-page: 261 year: 2008 ident: BFmp200953_CR20 publication-title: Mol Psychiatry doi: 10.1038/sj.mp.4002049 contributor: fullname: JI Friedman – volume: 16 start-page: 463 year: 2007 ident: BFmp200953_CR5 publication-title: Hum Mol Genet doi: 10.1093/hmg/ddl468 contributor: fullname: SJ Hebbring – volume: 17 start-page: 381 year: 2007 ident: BFmp200953_CR66 publication-title: Curr Opin Genet Dev doi: 10.1016/j.gde.2007.08.009 contributor: fullname: A Reymond – volume: 278 start-page: 22838 year: 2003 ident: BFmp200953_CR51 publication-title: J Biol Chem doi: 10.1074/jbc.M212969200 contributor: fullname: Z Yin – volume: 3 start-page: e1944 year: 2008 ident: BFmp200953_CR55 publication-title: PLoS ONE doi: 10.1371/journal.pone.0001944 contributor: fullname: D Matsuzawa – volume: 455 start-page: 919 year: 2008 ident: BFmp200953_CR10 publication-title: Nature doi: 10.1038/nature07458 contributor: fullname: EH Cook Jr – volume: 32 start-page: 1357 year: 2007 ident: BFmp200953_CR58 publication-title: Neurochem Res doi: 10.1007/s11064-007-9315-z contributor: fullname: R Janaky – volume: 40 start-page: 325 year: 2003 ident: BFmp200953_CR16 publication-title: J Med Genet doi: 10.1136/jmg.40.5.325 contributor: fullname: D Kamnasaran – volume: 79 start-page: 586 year: 2006 ident: BFmp200953_CR57 publication-title: Am J Hum Genet doi: 10.1086/507566 contributor: fullname: M Tosic – volume: 56 start-page: 940 year: 1999 ident: BFmp200953_CR12 publication-title: Arch Gen Psychiatry doi: 10.1001/archpsyc.56.10.940 contributor: fullname: KC Murphy – volume: 17 start-page: 1665 year: 2007 ident: BFmp200953_CR34 publication-title: Genome Res doi: 10.1101/gr.6861907 contributor: fullname: K Wang – volume: 87 start-page: 42 year: 2007 ident: BFmp200953_CR38 publication-title: Neurobiol Learn Mem doi: 10.1016/j.nlm.2006.05.004 contributor: fullname: L Gimenez-Llort – volume: 10 start-page: 265 year: 2004 ident: BFmp200953_CR39 publication-title: Parkinsonism Relat Disord doi: 10.1016/j.parkreldis.2004.02.014 contributor: fullname: S Ferre – volume: 4 start-page: 15 year: 2003 ident: BFmp200953_CR50 publication-title: BMC Genomics doi: 10.1186/1471-2164-4-15 contributor: fullname: JS Sutcliffe – volume: 455 start-page: 237 year: 2008 ident: BFmp200953_CR23 publication-title: Nature doi: 10.1038/nature07239 contributor: fullname: JL Stone – volume: 163 start-page: 529 year: 2006 ident: BFmp200953_CR48 publication-title: Am J Psychiatry doi: 10.1176/appi.ajp.163.3.529 contributor: fullname: T Lencz – volume: 73 start-page: 34 year: 2003 ident: BFmp200953_CR62 publication-title: Am J Hum Genet doi: 10.1086/376549 contributor: fullname: CM Lewis – volume: 14 start-page: 147 year: 2004 ident: BFmp200953_CR54 publication-title: Psychiatr Genet doi: 10.1097/00041444-200409000-00005 contributor: fullname: CU Pae – start-page: 3 volume-title: Glutathione in the Nervous System year: 1998 ident: BFmp200953_CR61 contributor: fullname: C Shaw – volume: 444 start-page: 444 year: 2006 ident: BFmp200953_CR35 publication-title: Nature doi: 10.1038/nature05329 contributor: fullname: R Redon – volume: 67 start-page: 400 year: 2005 ident: BFmp200953_CR41 publication-title: Mol Pharmacol doi: 10.1124/mol.104.003376 contributor: fullname: M Torvinen – volume: 281 start-page: 267 year: 2001 ident: BFmp200953_CR53 publication-title: Biochem Biophys Res Commun doi: 10.1006/bbrc.2001.4347 contributor: fullname: S Harada – volume: 7 start-page: 85 year: 2006 ident: BFmp200953_CR3 publication-title: Nat Rev Genet doi: 10.1038/nrg1767 contributor: fullname: L Feuk – volume: 17 start-page: 458 year: 2008 ident: BFmp200953_CR21 publication-title: Hum Mol Genet doi: 10.1093/hmg/ddm323 contributor: fullname: G Kirov – volume: 71 start-page: 1296 year: 2002 ident: BFmp200953_CR65 publication-title: Am J Hum Genet doi: 10.1086/344514 contributor: fullname: S Shifman – volume: 18 start-page: 683 year: 2008 ident: BFmp200953_CR28 publication-title: Genome Res doi: 10.1101/gr.073197.107 contributor: fullname: I Cusco – volume: 30 start-page: e57 year: 2002 ident: BFmp200953_CR30 publication-title: Nucleic Acids Res doi: 10.1093/nar/gnf056 contributor: fullname: JP Schouten – volume: 24 start-page: 86 year: 2004 ident: BFmp200953_CR29 publication-title: Hum Mutat doi: 10.1002/humu.20054 contributor: fullname: SJ White – volume: 267 start-page: 4904 year: 2000 ident: BFmp200953_CR67 publication-title: Eur J Biochem doi: 10.1046/j.1432-1327.2000.01595.x contributor: fullname: JB Schulz – volume: 73 start-page: 889 year: 1999 ident: BFmp200953_CR60 publication-title: J Neurochem doi: 10.1046/j.1471-4159.1999.0730889.x contributor: fullname: R Janaky – volume: 344 start-page: 531 year: 2006 ident: BFmp200953_CR19 publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2006.03.156 contributor: fullname: HJ Moon – volume: 141B start-page: 149 year: 2006 ident: BFmp200953_CR47 publication-title: Am J Med Genet B Neuropsychiatr Genet doi: 10.1002/ajmg.b.30273 contributor: fullname: SJ Glatt – volume: 307 start-page: 1434 year: 2005 ident: BFmp200953_CR9 publication-title: Science (New York, NY) doi: 10.1126/science.1101160 contributor: fullname: E Gonzalez – volume: 275 start-page: 34017 year: 2000 ident: BFmp200953_CR37 publication-title: J Biol Chem doi: 10.1074/jbc.C000429200 contributor: fullname: MM Lai – volume: 96 start-page: 93 year: 2007 ident: BFmp200953_CR18 publication-title: Schizophr Res doi: 10.1016/j.schres.2007.07.029 contributor: fullname: SR Sutrala – volume: 36 start-page: 949 year: 2004 ident: BFmp200953_CR27 publication-title: Nat Genet doi: 10.1038/ng1416 contributor: fullname: AJ Iafrate – volume: 79 start-page: 439 year: 2006 ident: BFmp200953_CR8 publication-title: Am J Hum Genet doi: 10.1086/505915 contributor: fullname: K Fellermann – volume: 439 start-page: 851 year: 2006 ident: BFmp200953_CR7 publication-title: Nature doi: 10.1038/nature04489 contributor: fullname: TJ Aitman – volume: 6 start-page: 193 year: 2001 ident: BFmp200953_CR43 publication-title: Mol Psychiatry doi: 10.1038/sj.mp.4000825 contributor: fullname: T Saito – volume: 60 start-page: 851 year: 1997 ident: BFmp200953_CR11 publication-title: Am J Hum Genet contributor: fullname: C Carlson – volume: 38 start-page: 1038 year: 2006 ident: BFmp200953_CR49 publication-title: Nat Genet doi: 10.1038/ng1862 contributor: fullname: AJ Sharp – volume: 9 start-page: 27 year: 2008 ident: BFmp200953_CR33 publication-title: BMC Med Genet doi: 10.1186/1471-2350-9-27 contributor: fullname: I Cusco – volume: 320 start-page: 539 year: 2008 ident: BFmp200953_CR25 publication-title: Science (New York, NY) doi: 10.1126/science.1155174 contributor: fullname: T Walsh – volume: 310 start-page: 1187 year: 2005 ident: BFmp200953_CR15 publication-title: Science (New York, NY) doi: 10.1126/science.1112915 contributor: fullname: JK Millar – volume: 147B start-page: 1040 year: 2008 ident: BFmp200953_CR52 publication-title: Am J Med Genet B Neuropsychiatr Genet doi: 10.1002/ajmg.b.30703 contributor: fullname: T Hashimoto – ident: BFmp200953_CR26 doi: 10.1002/ajmg.b.30902 – volume: 455 start-page: 232 year: 2008 ident: BFmp200953_CR24 publication-title: Nature doi: 10.1038/nature07229 contributor: fullname: H Stefansson – volume: 7 start-page: 745 year: 2002 ident: BFmp200953_CR46 publication-title: Mol Psychiatry doi: 10.1038/sj.mp.4001049 contributor: fullname: M Nyegaard – volume: 78 start-page: 339 year: 2005 ident: BFmp200953_CR44 publication-title: Schizophr Res doi: 10.1016/j.schres.2005.03.023 contributor: fullname: I Wonodi – volume: 39 start-page: S22 issue: 7 Suppl year: 2007 ident: BFmp200953_CR4 publication-title: Nat Genet doi: 10.1038/ng2054 contributor: fullname: GM Cooper – volume: 15 start-page: 743 year: 2006 ident: BFmp200953_CR17 publication-title: Hum Mol Genet doi: 10.1093/hmg/ddi489 contributor: fullname: GM Wilson – volume: 40 start-page: 907 year: 2003 ident: BFmp200953_CR32 publication-title: J Med Genet doi: 10.1136/jmg.40.12.907 contributor: fullname: HR Slater – volume: 21 start-page: 157 year: 2008 ident: BFmp200953_CR36 publication-title: Curr Opin Psychiatry doi: 10.1097/YCO.0b013e3282f4efde contributor: fullname: PF Sullivan – volume: 24 start-page: 164 year: 2004 ident: BFmp200953_CR31 publication-title: Hum Mutat doi: 10.1002/humu.20072 contributor: fullname: H Slater – volume: 26 start-page: 209 year: 2005 ident: BFmp200953_CR40 publication-title: J Mol Neurosci doi: 10.1385/JMN:26:2-3:209 contributor: fullname: K Fuxe – volume: 40 start-page: 880 year: 2008 ident: BFmp200953_CR22 publication-title: Nat Genet doi: 10.1038/ng.162 contributor: fullname: B Xu – volume: 7 start-page: 25 year: 2006 ident: BFmp200953_CR6 publication-title: Pharmacogenomics doi: 10.2217/14622416.7.1.25 contributor: fullname: K Ouahchi – volume: 7 start-page: 407 year: 2006 ident: BFmp200953_CR1 publication-title: Annu Rev Genomics Hum Genet doi: 10.1146/annurev.genom.7.080505.115618 contributor: fullname: AJ Sharp – volume: 14 start-page: 313 year: 2003 ident: BFmp200953_CR42 publication-title: Neuroreport doi: 10.1097/00001756-200303030-00003 contributor: fullname: J Deckert – volume: 12 start-page: 3721 year: 2000 ident: BFmp200953_CR59 publication-title: Eur J Neurosci doi: 10.1046/j.1460-9568.2000.00229.x contributor: fullname: KQ Do – volume: 8 start-page: 275 year: 2003 ident: BFmp200953_CR14 publication-title: Mol Psychiatry doi: 10.1038/sj.mp.4001232 contributor: fullname: DJ MacIntyre – volume: 55 start-page: 509 year: 2003 ident: BFmp200953_CR45 publication-title: Pharmacol Rev doi: 10.1124/pr.55.3.2 contributor: fullname: LF Agnati – volume: 89 start-page: 167 year: 2007 ident: BFmp200953_CR64 publication-title: Genomics doi: 10.1016/j.ygeno.2006.10.001 contributor: fullname: KB Bulayeva |
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Snippet | Copy number variants (CNVs) are a substantial source of human genetic diversity, influencing the variable susceptibility to multifactorial disorders.... |
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SubjectTerms | Adult Aged Behavioral Sciences Biological Psychology Chromosome 16 Copy number Disease Environmental effects Female Gene Dosage - genetics Gene Duplication - genetics Genes Genetic aspects Genetic diversity Genetic Predisposition to Disease - epidemiology Genetic Variation Genomics Genotype Genotypes Glutathione transferase Glutathione Transferase - genetics GSTM1 protein Humans Male Medicine Medicine & Public Health Mental disorders Metabolism Middle Aged Mutation Neurosciences original-article Pharmacotherapy Physiological aspects Prevalence Psychiatry Risk Factors Schizophrenia Schizophrenia - epidemiology Schizophrenia - genetics Somatostatin Somatostatin receptors Statistical analysis Susceptibility |
Title | Association of common copy number variants at the glutathione S-transferase genes and rare novel genomic changes with schizophrenia |
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