Quantitative objective markers for upper and lower motor neuron dysfunction in ALS

• Published in: Neurology Vol. 68; no. 17; p. 1402
• Main Authors: Mitsumoto, H, Ulug, A M, Pullman, S L, Gooch, C L, Chan, S, Tang, M-X, Mao, X, Hays, A P, Floyd, A G, Battista, V, Montes, J, Hayes, S, Dashnaw, S, Kaufmann, P, Gordon, P H, Hirsch, J, Levin, B, Rowland, L P, Shungu, D C
• Format: Journal Article
• Language: English
• Published: United States 24.04.2007
• Subjects: Adult; Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis - classification; Amyotrophic Lateral Sclerosis - pathology; Amyotrophic Lateral Sclerosis - physiopathology; Aspartic Acid - analogs & derivatives; Aspartic Acid - analysis; Biomarkers; Creatine - analysis; Diffusion Magnetic Resonance Imaging; Female; Follow-Up Studies; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex - chemistry; Motor Neuron Disease - pathology; Motor Neuron Disease - physiopathology; Motor Neurons - physiology; Muscular Atrophy, Spinal - pathology; Muscular Atrophy, Spinal - physiopathology; Neural Conduction; Prospective Studies; Transcranial Magnetic Stimulation
• ISSN: 1526-632X
• DOI: 10.1212/01.wnl.0000260065.57832.87

To investigate the value of objective biomarkers for upper (UMN) and lower (LMN) motor neuron involvement in ALS. We prospectively studied 64 patients with ALS and its subsets using clinical measures, proton MR spectroscopic imaging ((1)H MRSI), diffusion tensor imaging, transcranial magnetic stimul...