The Cellular Composition and Macrophage Phenotype in Induced Sputum in Smokers and Ex-Smokers With COPD

• Published in: Chest Vol. 123; no. 4; pp. 1054 - 1059
• Main Authors: Domagała-Kulawik, Joanna, Maskey-Warzęchowska, Marta, Kraszewska, Izabela, Chazan, Ryszarda
• Format: Journal Article
• Language: English
• Published: Northbrook, IL Elsevier Inc 01.04.2003; American College of Chest Physicians
• Subjects: Aged; Airway management; Antigens, CD - metabolism; Biological and medical sciences; Cell Count; Chronic obstructive pulmonary disease; Chronic obstructive pulmonary disease, asthma; COPD; ex-smokers; Female; Genotype & phenotype; Humans; Immunohistochemistry; induced sputum; Inflammation; Inflammation - pathology; Investigations; Lung - pathology; macrophages; Macrophages - metabolism; Male; Medical sciences; Middle Aged; Phenotype; Pneumology; Prospective Studies; Pulmonary Disease, Chronic Obstructive - pathology; Respiratory Function Tests; smokers; Smoking - pathology; Smoking cessation; Specimen Handling; Spirometry; Sputum - cytology; macrophages; BALF; induced sputum; IS; ex-smokers; smokers; AM; COPD; Human; Lung disease; Respiratory disease; Immunocytochemistry; Cytology; Tobacco smoking; Exploration; Pathology; Toxicology; Concomitant disease; Shutdown; Sputum; Bronchus disease; Obstructive pulmonary disease; Comparative study; Macrophage

The relationship between smoking and COPD has been well-documented. We investigated the impact of cigarette smoking on airway inflammation in COPD patients. Changes in cell profiles in induced sputum (IS) samples from smokers with COPD and patients who ceased smoking were compared. Department of pne...