Modulation of HLA-G antigens expression in myelomonocytic cells

• Published in: Human immunology Vol. 61; no. 11; pp. 1086 - 1094
• Main Authors: Onno, Myriam, Le Friec, Gaëlle, Pangault, Céline, Amiot, Laurence, Guilloux, Valérie, Drénou, Bernard, Caulet-Maugendre, Sylvie, André, Patrice, Fauchet, Renée
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2000
• Subjects: Acute Disease; Biopsy; Carcinoma - immunology; Carcinoma - pathology; Cell Line; Cytokines - pharmacology; Dendritic Cells - immunology; Flow Cytometry; histocompatibility antigen HLA; Histocompatibility Antigens Class I - biosynthesis; Histocompatibility Antigens Class I - immunology; HLA Antigens - biosynthesis; HLA Antigens - immunology; HLA-G Antigens; human cytomegalovirus; Humans; inflammation; Lung - immunology; Lung - pathology; Lung Neoplasms - immunology; Lung Neoplasms - pathology; Macrophage Activation; macrophages; Macrophages - drug effects; Macrophages - immunology; Monocytes - drug effects; Monocytes - immunology; Monocytes - virology; Pneumonia, Viral - immunology; tolerance; U937 Cells; CD; NK cells; IL; HLA-G antigens; HCMV; human cytomegalovirus; PBMC; BAL; bp; mAb; BSA; macrophages; FITC; IFN-γ; inflammation; GM-CSF; KIR; CTL; gB; IE; TRITC; tolerance

As trophoblast cells and macrophages share cellular characteristics, we investigated the expression of HLA-G antigens during the myelomonocytic differentiation. Analyses with the 87G and 16G1 monoclonal antibodies demonstrated that HLA-G was not expressed in peripheral blood monocytes, in in vitro d...