A Light-Driven Therapy of Pancreatic Adenocarcinoma Using Gold Nanorods-Based Nanocarriers for Co-Delivery of Doxorubicin and siRNA

• Published in: Theranostics Vol. 5; no. 8; pp. 818 - 833
• Main Authors: Yin, Feng, Yang, Chengbin, Wang, Qianqian, Zeng, Shuwen, Hu, Rui, Lin, Guimiao, Tian, Jinglin, Hu, Siyi, Lan, Rong Feng, Yoon, Ho Sup, Lu, Fei, Wang, Kuan, Yong, Ken-Tye
• Format: Journal Article
• Language: English
• Published: Australia Ivyspring International Publisher 01.01.2015
• Subjects: Adenocarcinoma - drug therapy; Animals; Antineoplastic Agents - administration & dosage; Cell Line, Tumor; Cell Survival - drug effects; Disease Models, Animal; Doxorubicin - administration & dosage; Drug Carriers - administration & dosage; Female; Gold - administration & dosage; Humans; Hyperthermia, Induced - methods; Light; Mice, Nude; Nanotubes; Pancreatic Neoplasms - drug therapy; Phototherapy - methods; Research Paper; RNA, Small Interfering - administration & dosage; Treatment Outcome; Pancreatic adenocarcinoma; AuNRs; tumors; siRNA; K-Ras; Doxorubicin

In this work, we report the engineering of polyelectrolyte polymers coated Gold nanorods (AuNRs)-based nanocarriers that are capable of co-delivering small interfering RNA (siRNA) and an anticancer drug doxorubicin (DOX) to Panc-1 cancer cells for combination of both chemo- and siRNA-mediated mutant...