A Germline Mutation (A339V) in Thyroid Transcription Factor-1 (TITF-1/NKX2.1) in Patients With Multinodular Goiter and Papillary Thyroid Carcinoma
Background The genetic factors that determine the risk of papillary thyroid carcinoma (PTC) among patients with multinodular goiter (MNG) remain undefined. Because thyroid transcription factor-1 (TTF-1) is important to thyroid development, we evaluated whether the gene that encodes it, TITF-1/NKX2.1...
Saved in:
| Published in | JNCI : Journal of the National Cancer Institute Vol. 101; no. 3; pp. 162 - 175 |
|---|---|
| Main Authors | , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Cary, NC
Oxford University Press
04.02.2009
Oxford Publishing Limited (England) |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Background The genetic factors that determine the risk of papillary thyroid carcinoma (PTC) among patients with multinodular goiter (MNG) remain undefined. Because thyroid transcription factor-1 (TTF-1) is important to thyroid development, we evaluated whether the gene that encodes it, TITF-1/NKX2.1, is a genetic determinant of MNG/PTC predisposition. Methods Twenty unrelated PTC patients with a history of MNG (MNG/PTC), 284 PTC patients without a history of MNG (PTC), and 349 healthy control subjects were screened for germline mutation(s) in TITF-1/NKX2.1 by sequencing of amplified DNA from blood. The effects of the mutation on the growth and differentiation of thyroid cells were demonstrated by ectopic expression of wild-type (WT) and mutant proteins in PCCL3 normal rat thyroid cells, followed by tests of cell proliferation, activation of cell growth pathways, and transcription of TTF-1 target genes. All statistical tests were two-sided. Results A missense mutation (1016C>T) was identified in TITF-1/NKX2.1 that led to a mutant TTF-1 protein (A339V) in four of the 20 MNG/PTC patients (20%). These patients developed substantially more advanced tumors than MNG/PTC or PTC patients without the mutation (P = .022, Fisher exact test). Notably, this germline mutation was dominantly inherited in two families, with some members bearing the mutation affected with MNG, associated with either PTC or colon cancer. The mutation encoding the A339V substitution was not found among the 349 healthy control subjects nor among the 284 PTC patients who had no history of MNG. Overexpression of A339V TTF-1 in PCCL3 cells, as compared with overexpression of WT TTF-1, was associated with increased cell proliferation including thyrotropin-independent growth (average A339V proliferation rate = 134.27%, WT rate = 104.43%, difference = 34.3%, 95% confidence interval = 12.0% to 47.7%, P = .010), enhanced STAT3 activation, and impaired transcription of the thyroid-specific genes Tg, TSH-R, and Pax-8. Conclusion This is the first germline mutation identified in MNG/PTC patients. It could contribute to predisposition for MNG and/or PTC and to the pathogenesis of PTC. |
|---|---|
| AbstractList | Background: The genetic factors that determine the risk of papillary thyroid carcinoma (PTC) among patients with multinodular goiter (MNG) remain undefined. Because thyroid transcription factor-1 (TTF-1) is important to thyroid development, we evaluated whether the gene that encodes it, TITF-1/NKX2.1 , is a genetic determinant of MNG/PTC predisposition. Methods: Twenty unrelated PTC patients with a history of MNG (MNG/PTC), 284 PTC patients without a history of MNG (PTC), and 349 healthy control subjects were screened for germline mutation(s) in TITF-1/NKX2.1 by sequencing of amplified DNA from blood. The effects of the mutation on the growth and differentiation of thyroid cells were demonstrated by ectopic expression of wild-type (WT) and mutant proteins in PCCL3 normal rat thyroid cells, followed by tests of cell proliferation, activation of cell growth pathways, and transcription of TTF-1 target genes. All statistical tests were two-sided. Results: A missense mutation (1016C>T) was identified in TITF-1/NKX2.1 that led to a mutant TTF-1 protein (A339V) in four of the 20 MNG/PTC patients (20%). These patients developed substantially more advanced tumors than MNG/PTC or PTC patients without the mutation (P = .022, Fisher exact test). Notably, this germline mutation was dominantly inherited in two families, with some members bearing the mutation affected with MNG, associated with either PTC or colon cancer. The mutation encoding the A339V substitution was not found among the 349 healthy control subjects nor among the 284 PTC patients who had no history of MNG. Overexpression of A339V TTF-1 in PCCL3 cells, as compared with overexpression of WT TTF-1, was associated with increased cell proliferation including thyrotropin-independent growth (average A339V proliferation rate = 134.27%, WT rate = 104.43%, difference = 34.3%, 95% confidence interval = 12.0% to 47.7%, P = .010), enhanced STAT3 activation, and impaired transcription of the thyroid-specific genes Tg , TSH-R , and Pax-8 . Conclusion: This is the first germline mutation identified in MNG/PTC patients. It could contribute to predisposition for MNG and/or PTC and to the pathogenesis of PTC. [PUBLICATION ABSTRACT] Background The genetic factors that determine the risk of papillary thyroid carcinoma (PTC) among patients with multinodular goiter (MNG) remain undefined. Because thyroid transcription factor-1 (TTF-1) is important to thyroid development, we evaluated whether the gene that encodes it, TITF-1/NKX2.1, is a genetic determinant of MNG/PTC predisposition. Methods Twenty unrelated PTC patients with a history of MNG (MNG/PTC), 284 PTC patients without a history of MNG (PTC), and 349 healthy control subjects were screened for germline mutation(s) in TITF-1/NKX2.1 by sequencing of amplified DNA from blood. The effects of the mutation on the growth and differentiation of thyroid cells were demonstrated by ectopic expression of wild-type (WT) and mutant proteins in PCCL3 normal rat thyroid cells, followed by tests of cell proliferation, activation of cell growth pathways, and transcription of TTF-1 target genes. All statistical tests were two-sided. Results A missense mutation (1016C>T) was identified in TITF-1/NKX2.1 that led to a mutant TTF-1 protein (A339V) in four of the 20 MNG/PTC patients (20%). These patients developed substantially more advanced tumors than MNG/PTC or PTC patients without the mutation (P = .022, Fisher exact test). Notably, this germline mutation was dominantly inherited in two families, with some members bearing the mutation affected with MNG, associated with either PTC or colon cancer. The mutation encoding the A339V substitution was not found among the 349 healthy control subjects nor among the 284 PTC patients who had no history of MNG. Overexpression of A339V TTF-1 in PCCL3 cells, as compared with overexpression of WT TTF-1, was associated with increased cell proliferation including thyrotropin-independent growth (average A339V proliferation rate = 134.27%, WT rate = 104.43%, difference = 34.3%, 95% confidence interval = 12.0% to 47.7%, P = .010), enhanced STAT3 activation, and impaired transcription of the thyroid-specific genes Tg, TSH-R, and Pax-8. Conclusion This is the first germline mutation identified in MNG/PTC patients. It could contribute to predisposition for MNG and/or PTC and to the pathogenesis of PTC. Background The genetic factors that determine the risk of papillary thyroid carcinoma (PTC) among patients with multinodular goiter (MNG) remain undefined. Because thyroid transcription factor-1 (TTF-1) is important to thyroid development, we evaluated whether the gene that encodes it, TITF-1/NKX2.1, is a genetic determinant of MNG/PTC predisposition. Methods Twenty unrelated PTC patients with a history of MNG (MNG/PTC), 284 PTC patients without a history of MNG (PTC), and 349 healthy control subjects were screened for germline mutation(s) in TITF-1/NKX2.1 by sequencing of amplified DNA from blood. The effects of the mutation on the growth and differentiation of thyroid cells were demonstrated by ectopic expression of wild-type (WT) and mutant proteins in PCCL3 normal rat thyroid cells, followed by tests of cell proliferation, activation of cell growth pathways, and transcription of TTF-1 target genes. All statistical tests were two-sided. Results A missense mutation (1016C>T) was identified in TITF-1/NKX2.1 that led to a mutant TTF-1 protein (A339V) in four of the 20 MNG/PTC patients (20%). These patients developed substantially more advanced tumors than MNG/PTC or PTC patients without the mutation (P = .022, Fisher exact test). Notably, this germline mutation was dominantly inherited in two families, with some members bearing the mutation affected with MNG, associated with either PTC or colon cancer. The mutation encoding the A339V substitution was not found among the 349 healthy control subjects nor among the 284 PTC patients who had no history of MNG. Overexpression of A339V TTF-1 in PCCL3 cells, as compared with overexpression of WT TTF-1, was associated with increased cell proliferation including thyrotropin-independent growth (average A339V proliferation rate = 134.27%, WT rate = 104.43%, difference = 34.3%, 95% confidence interval = 12.0% to 47.7%, P = .010), enhanced STAT3 activation, and impaired transcription of the thyroid-specific genes Tg, TSH-R, and Pax-8. Conclusion This is the first germline mutation identified in MNG/PTC patients. It could contribute to predisposition for MNG and/or PTC and to the pathogenesis of PTC. The genetic factors that determine the risk of papillary thyroid carcinoma (PTC) among patients with multinodular goiter (MNG) remain undefined. Because thyroid transcription factor-1 (TTF-1) is important to thyroid development, we evaluated whether the gene that encodes it, TITF-1/NKX2.1, is a genetic determinant of MNG/PTC predisposition.BACKGROUNDThe genetic factors that determine the risk of papillary thyroid carcinoma (PTC) among patients with multinodular goiter (MNG) remain undefined. Because thyroid transcription factor-1 (TTF-1) is important to thyroid development, we evaluated whether the gene that encodes it, TITF-1/NKX2.1, is a genetic determinant of MNG/PTC predisposition.Twenty unrelated PTC patients with a history of MNG (MNG/PTC), 284 PTC patients without a history of MNG (PTC), and 349 healthy control subjects were screened for germline mutation(s) in TITF-1/NKX2.1 by sequencing of amplified DNA from blood. The effects of the mutation on the growth and differentiation of thyroid cells were demonstrated by ectopic expression of wild-type (WT) and mutant proteins in PCCL3 normal rat thyroid cells, followed by tests of cell proliferation, activation of cell growth pathways, and transcription of TTF-1 target genes. All statistical tests were two-sided.METHODSTwenty unrelated PTC patients with a history of MNG (MNG/PTC), 284 PTC patients without a history of MNG (PTC), and 349 healthy control subjects were screened for germline mutation(s) in TITF-1/NKX2.1 by sequencing of amplified DNA from blood. The effects of the mutation on the growth and differentiation of thyroid cells were demonstrated by ectopic expression of wild-type (WT) and mutant proteins in PCCL3 normal rat thyroid cells, followed by tests of cell proliferation, activation of cell growth pathways, and transcription of TTF-1 target genes. All statistical tests were two-sided.A missense mutation (1016C>T) was identified in TITF-1/NKX2.1 that led to a mutant TTF-1 protein (A339V) in four of the 20 MNG/PTC patients (20%). These patients developed substantially more advanced tumors than MNG/PTC or PTC patients without the mutation (P = .022, Fisher exact test). Notably, this germline mutation was dominantly inherited in two families, with some members bearing the mutation affected with MNG, associated with either PTC or colon cancer. The mutation encoding the A339V substitution was not found among the 349 healthy control subjects nor among the 284 PTC patients who had no history of MNG. Overexpression of A339V TTF-1 in PCCL3 cells, as compared with overexpression of WT TTF-1, was associated with increased cell proliferation including thyrotropin-independent growth (average A339V proliferation rate = 134.27%, WT rate = 104.43%, difference = 34.3%, 95% confidence interval = 12.0% to 47.7%, P = .010), enhanced STAT3 activation, and impaired transcription of the thyroid-specific genes Tg, TSH-R, and Pax-8.RESULTSA missense mutation (1016C>T) was identified in TITF-1/NKX2.1 that led to a mutant TTF-1 protein (A339V) in four of the 20 MNG/PTC patients (20%). These patients developed substantially more advanced tumors than MNG/PTC or PTC patients without the mutation (P = .022, Fisher exact test). Notably, this germline mutation was dominantly inherited in two families, with some members bearing the mutation affected with MNG, associated with either PTC or colon cancer. The mutation encoding the A339V substitution was not found among the 349 healthy control subjects nor among the 284 PTC patients who had no history of MNG. Overexpression of A339V TTF-1 in PCCL3 cells, as compared with overexpression of WT TTF-1, was associated with increased cell proliferation including thyrotropin-independent growth (average A339V proliferation rate = 134.27%, WT rate = 104.43%, difference = 34.3%, 95% confidence interval = 12.0% to 47.7%, P = .010), enhanced STAT3 activation, and impaired transcription of the thyroid-specific genes Tg, TSH-R, and Pax-8.This is the first germline mutation identified in MNG/PTC patients. It could contribute to predisposition for MNG and/or PTC and to the pathogenesis of PTC.CONCLUSIONThis is the first germline mutation identified in MNG/PTC patients. It could contribute to predisposition for MNG and/or PTC and to the pathogenesis of PTC. The genetic factors that determine the risk of papillary thyroid carcinoma (PTC) among patients with multinodular goiter (MNG) remain undefined. Because thyroid transcription factor-1 (TTF-1) is important to thyroid development, we evaluated whether the gene that encodes it, TITF-1/NKX2.1, is a genetic determinant of MNG/PTC predisposition. Twenty unrelated PTC patients with a history of MNG (MNG/PTC), 284 PTC patients without a history of MNG (PTC), and 349 healthy control subjects were screened for germline mutation(s) in TITF-1/NKX2.1 by sequencing of amplified DNA from blood. The effects of the mutation on the growth and differentiation of thyroid cells were demonstrated by ectopic expression of wild-type (WT) and mutant proteins in PCCL3 normal rat thyroid cells, followed by tests of cell proliferation, activation of cell growth pathways, and transcription of TTF-1 target genes. All statistical tests were two-sided. A missense mutation (1016C>T) was identified in TITF-1/NKX2.1 that led to a mutant TTF-1 protein (A339V) in four of the 20 MNG/PTC patients (20%). These patients developed substantially more advanced tumors than MNG/PTC or PTC patients without the mutation (P = .022, Fisher exact test). Notably, this germline mutation was dominantly inherited in two families, with some members bearing the mutation affected with MNG, associated with either PTC or colon cancer. The mutation encoding the A339V substitution was not found among the 349 healthy control subjects nor among the 284 PTC patients who had no history of MNG. Overexpression of A339V TTF-1 in PCCL3 cells, as compared with overexpression of WT TTF-1, was associated with increased cell proliferation including thyrotropin-independent growth (average A339V proliferation rate = 134.27%, WT rate = 104.43%, difference = 34.3%, 95% confidence interval = 12.0% to 47.7%, P = .010), enhanced STAT3 activation, and impaired transcription of the thyroid-specific genes Tg, TSH-R, and Pax-8. This is the first germline mutation identified in MNG/PTC patients. It could contribute to predisposition for MNG and/or PTC and to the pathogenesis of PTC. |
| Author | Ngan, Elly S. W. Garcia-Barceló, Maria-Mercè Shum, Cathy K. Y. Cherny, Stacey S. So, Man-Ting Leon, Thomas Y. Y. Lo, Chung-Yau Tam, Paul K. H. Liu, Tingting Tsai, Sophia Y. Lang, Brian H. H. Lau, Danny K. C. Khoo, Ui-Soon |
| Author_xml | – sequence: 1 givenname: Elly S. W. surname: Ngan fullname: Ngan, Elly S. W. email: engan@hku.hk organization: Affiliations of authors: Department of Surgery, Centre for Cancer Research, Centre for Reproduction, Development and Growth (ESWN), Department of Surgery (BHHL, TL, CKYS, M-TS, DKCL, TYYL, C-YL), Department of Surgery, Centre for Reproduction, Development and Growth (PKHT), Department of Surgery, Centre for Reproduction, Development and Growth (M-MG-B), Department of Pathology (U-SK), Department of Psychiatry (SSC), Genome Research Centre (SSC), University of Hong Kong, Pokfulam, Hong Kong; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX (SYT) – sequence: 2 givenname: Brian H. H. surname: Lang fullname: Lang, Brian H. H. organization: Affiliations of authors: Department of Surgery, Centre for Cancer Research, Centre for Reproduction, Development and Growth (ESWN), Department of Surgery (BHHL, TL, CKYS, M-TS, DKCL, TYYL, C-YL), Department of Surgery, Centre for Reproduction, Development and Growth (PKHT), Department of Surgery, Centre for Reproduction, Development and Growth (M-MG-B), Department of Pathology (U-SK), Department of Psychiatry (SSC), Genome Research Centre (SSC), University of Hong Kong, Pokfulam, Hong Kong; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX (SYT) – sequence: 3 givenname: Tingting surname: Liu fullname: Liu, Tingting organization: Affiliations of authors: Department of Surgery, Centre for Cancer Research, Centre for Reproduction, Development and Growth (ESWN), Department of Surgery (BHHL, TL, CKYS, M-TS, DKCL, TYYL, C-YL), Department of Surgery, Centre for Reproduction, Development and Growth (PKHT), Department of Surgery, Centre for Reproduction, Development and Growth (M-MG-B), Department of Pathology (U-SK), Department of Psychiatry (SSC), Genome Research Centre (SSC), University of Hong Kong, Pokfulam, Hong Kong; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX (SYT) – sequence: 4 givenname: Cathy K. Y. surname: Shum fullname: Shum, Cathy K. Y. organization: Affiliations of authors: Department of Surgery, Centre for Cancer Research, Centre for Reproduction, Development and Growth (ESWN), Department of Surgery (BHHL, TL, CKYS, M-TS, DKCL, TYYL, C-YL), Department of Surgery, Centre for Reproduction, Development and Growth (PKHT), Department of Surgery, Centre for Reproduction, Development and Growth (M-MG-B), Department of Pathology (U-SK), Department of Psychiatry (SSC), Genome Research Centre (SSC), University of Hong Kong, Pokfulam, Hong Kong; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX (SYT) – sequence: 5 givenname: Man-Ting surname: So fullname: So, Man-Ting organization: Affiliations of authors: Department of Surgery, Centre for Cancer Research, Centre for Reproduction, Development and Growth (ESWN), Department of Surgery (BHHL, TL, CKYS, M-TS, DKCL, TYYL, C-YL), Department of Surgery, Centre for Reproduction, Development and Growth (PKHT), Department of Surgery, Centre for Reproduction, Development and Growth (M-MG-B), Department of Pathology (U-SK), Department of Psychiatry (SSC), Genome Research Centre (SSC), University of Hong Kong, Pokfulam, Hong Kong; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX (SYT) – sequence: 6 givenname: Danny K. C. surname: Lau fullname: Lau, Danny K. C. organization: Affiliations of authors: Department of Surgery, Centre for Cancer Research, Centre for Reproduction, Development and Growth (ESWN), Department of Surgery (BHHL, TL, CKYS, M-TS, DKCL, TYYL, C-YL), Department of Surgery, Centre for Reproduction, Development and Growth (PKHT), Department of Surgery, Centre for Reproduction, Development and Growth (M-MG-B), Department of Pathology (U-SK), Department of Psychiatry (SSC), Genome Research Centre (SSC), University of Hong Kong, Pokfulam, Hong Kong; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX (SYT) – sequence: 7 givenname: Thomas Y. Y. surname: Leon fullname: Leon, Thomas Y. Y. organization: Affiliations of authors: Department of Surgery, Centre for Cancer Research, Centre for Reproduction, Development and Growth (ESWN), Department of Surgery (BHHL, TL, CKYS, M-TS, DKCL, TYYL, C-YL), Department of Surgery, Centre for Reproduction, Development and Growth (PKHT), Department of Surgery, Centre for Reproduction, Development and Growth (M-MG-B), Department of Pathology (U-SK), Department of Psychiatry (SSC), Genome Research Centre (SSC), University of Hong Kong, Pokfulam, Hong Kong; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX (SYT) – sequence: 8 givenname: Stacey S. surname: Cherny fullname: Cherny, Stacey S. organization: Affiliations of authors: Department of Surgery, Centre for Cancer Research, Centre for Reproduction, Development and Growth (ESWN), Department of Surgery (BHHL, TL, CKYS, M-TS, DKCL, TYYL, C-YL), Department of Surgery, Centre for Reproduction, Development and Growth (PKHT), Department of Surgery, Centre for Reproduction, Development and Growth (M-MG-B), Department of Pathology (U-SK), Department of Psychiatry (SSC), Genome Research Centre (SSC), University of Hong Kong, Pokfulam, Hong Kong; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX (SYT) – sequence: 9 givenname: Sophia Y. surname: Tsai fullname: Tsai, Sophia Y. organization: Affiliations of authors: Department of Surgery, Centre for Cancer Research, Centre for Reproduction, Development and Growth (ESWN), Department of Surgery (BHHL, TL, CKYS, M-TS, DKCL, TYYL, C-YL), Department of Surgery, Centre for Reproduction, Development and Growth (PKHT), Department of Surgery, Centre for Reproduction, Development and Growth (M-MG-B), Department of Pathology (U-SK), Department of Psychiatry (SSC), Genome Research Centre (SSC), University of Hong Kong, Pokfulam, Hong Kong; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX (SYT) – sequence: 10 givenname: Chung-Yau surname: Lo fullname: Lo, Chung-Yau organization: Affiliations of authors: Department of Surgery, Centre for Cancer Research, Centre for Reproduction, Development and Growth (ESWN), Department of Surgery (BHHL, TL, CKYS, M-TS, DKCL, TYYL, C-YL), Department of Surgery, Centre for Reproduction, Development and Growth (PKHT), Department of Surgery, Centre for Reproduction, Development and Growth (M-MG-B), Department of Pathology (U-SK), Department of Psychiatry (SSC), Genome Research Centre (SSC), University of Hong Kong, Pokfulam, Hong Kong; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX (SYT) – sequence: 11 givenname: Ui-Soon surname: Khoo fullname: Khoo, Ui-Soon organization: Affiliations of authors: Department of Surgery, Centre for Cancer Research, Centre for Reproduction, Development and Growth (ESWN), Department of Surgery (BHHL, TL, CKYS, M-TS, DKCL, TYYL, C-YL), Department of Surgery, Centre for Reproduction, Development and Growth (PKHT), Department of Surgery, Centre for Reproduction, Development and Growth (M-MG-B), Department of Pathology (U-SK), Department of Psychiatry (SSC), Genome Research Centre (SSC), University of Hong Kong, Pokfulam, Hong Kong; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX (SYT) – sequence: 12 givenname: Paul K. H. surname: Tam fullname: Tam, Paul K. H. organization: Affiliations of authors: Department of Surgery, Centre for Cancer Research, Centre for Reproduction, Development and Growth (ESWN), Department of Surgery (BHHL, TL, CKYS, M-TS, DKCL, TYYL, C-YL), Department of Surgery, Centre for Reproduction, Development and Growth (PKHT), Department of Surgery, Centre for Reproduction, Development and Growth (M-MG-B), Department of Pathology (U-SK), Department of Psychiatry (SSC), Genome Research Centre (SSC), University of Hong Kong, Pokfulam, Hong Kong; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX (SYT) – sequence: 13 givenname: Maria-Mercè surname: Garcia-Barceló fullname: Garcia-Barceló, Maria-Mercè organization: Affiliations of authors: Department of Surgery, Centre for Cancer Research, Centre for Reproduction, Development and Growth (ESWN), Department of Surgery (BHHL, TL, CKYS, M-TS, DKCL, TYYL, C-YL), Department of Surgery, Centre for Reproduction, Development and Growth (PKHT), Department of Surgery, Centre for Reproduction, Development and Growth (M-MG-B), Department of Pathology (U-SK), Department of Psychiatry (SSC), Genome Research Centre (SSC), University of Hong Kong, Pokfulam, Hong Kong; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX (SYT) |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21218109$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/19176457$$D View this record in MEDLINE/PubMed |
| BookMark | eNqF0ktvEzEQAGALFdE0cOKOVkigIrSNX_vwMUqbpKI8JBYScbG8Xq_qsGsH2yvRv8EvxmlCDhVSfbFkfTNje-YMnBhrFAAvEbxAkJHJxkg9aTaGFugJGCGawxQjmJ2AEYS4SMuyoKfgzPsNjIth-gycIoaKnGbFCPyZJgvl-k4blXwcggjamuR8Sgj7_i7RJqlu75zVTVI5Ybx0ensP5kIG61KUnFfX1TxFk08f1vgC3Ud8iTmUCT5Z6XAbc3ZBG9sMnXDJwuqgXCJME9VWd_Hs7lhhJpyMshfPwdNWdF69OOxj8G1-Vc2W6c3nxfVsepNKSmlIWZsLWjOIocIyy2GtcsEa2ciSIaIYkpIiobKW4KJmLKdlTVRGcZvVpMWspmQM3u7zbp39NSgfeK-9VPFWRtnB8zxnMCMFfhRiSLMcURjh6wdwYwdn4iM4ji0hFGW7bK8OaKh71fCt0338B_6vJxG8OQDhpeja-PNS-6PDCKNy1_gxQHsnnfXeqZZLvW9gcEJ3HEG-Y3w3H3w_HzHm_YOYY_n_6sPD7bB9BKZ7qH1Qv49UuJ88L0iR8eX6B59drldfV0vCF-QvFl3XIA |
| CODEN | JNCIEQ |
| CitedBy_id | crossref_primary_10_1136_jmedgenet_2013_101687 crossref_primary_10_3390_cancers12020423 crossref_primary_10_3390_ijms24098233 crossref_primary_10_1016_j_bbcan_2013_02_002 crossref_primary_10_1155_2021_9957209 crossref_primary_10_1007_s40618_015_0386_4 crossref_primary_10_1016_j_ejso_2016_08_006 crossref_primary_10_1089_thy_2018_0736 crossref_primary_10_1016_j_endinu_2020_08_002 crossref_primary_10_1007_s12020_024_04098_3 crossref_primary_10_1016_j_bbadis_2015_05_005 crossref_primary_10_1080_08820139_2017_1337785 crossref_primary_10_1210_jc_2011_2735 crossref_primary_10_1016_j_humpath_2017_10_025 crossref_primary_10_1016_j_ccr_2013_04_002 crossref_primary_10_1016_j_jbc_2024_105767 crossref_primary_10_3390_genes11111364 crossref_primary_10_1111_cen_13375 crossref_primary_10_3390_cancers13030470 crossref_primary_10_3390_genes10070482 crossref_primary_10_1051_medsci_2011272183 crossref_primary_10_3389_fonc_2024_1286426 crossref_primary_10_1089_thy_2023_0564 crossref_primary_10_1002_ijc_28543 crossref_primary_10_1007_s12020_021_02660_x crossref_primary_10_3390_biom9100605 crossref_primary_10_1007_s12020_020_02250_3 crossref_primary_10_1074_jbc_M116_740324 crossref_primary_10_1007_s40618_020_01435_x crossref_primary_10_1016_j_endien_2020_08_013 crossref_primary_10_1210_jc_2017_01241 crossref_primary_10_1007_s12020_014_0470_0 crossref_primary_10_1371_journal_pone_0281573 crossref_primary_10_1530_EC_21_0406 crossref_primary_10_1038_srep43396 crossref_primary_10_3390_cancers13092178 crossref_primary_10_1097_MD_0000000000002324 crossref_primary_10_14260_jemds_2016_665 crossref_primary_10_1089_thy_2020_0290 crossref_primary_10_1007_s12022_022_09705_5 crossref_primary_10_3892_mmr_2017_7346 crossref_primary_10_1530_EJE_13_0865 crossref_primary_10_1007_s12022_020_09661_y crossref_primary_10_1186_s13053_022_00215_3 crossref_primary_10_1038_nrendo_2014_186 crossref_primary_10_3390_jcm7040061 crossref_primary_10_1530_ERC_18_0160 crossref_primary_10_23736_S2724_6507_20_03338_6 crossref_primary_10_3390_ijms25031522 crossref_primary_10_1056_NEJMoa1502449 crossref_primary_10_3389_fendo_2020_589340 crossref_primary_10_1002_ajmg_a_38142 crossref_primary_10_1186_s12881_016_0323_1 crossref_primary_10_1111_cen_13316 crossref_primary_10_1530_ERC_16_0067 crossref_primary_10_1007_s12022_020_09607_4 crossref_primary_10_1016_S2173_5115_09_70170_8 crossref_primary_10_1038_srep10566 crossref_primary_10_1097_MD_0000000000001246 crossref_primary_10_4061_2011_710213 crossref_primary_10_1155_2021_3472000 crossref_primary_10_1002_ijc_31933 crossref_primary_10_1074_jbc_R113_491647 crossref_primary_10_1136_jmedgenet_2013_102248 crossref_primary_10_3389_fendo_2022_829103 crossref_primary_10_1111_j_1365_2265_2012_04505_x crossref_primary_10_1007_s12020_014_0256_4 crossref_primary_10_1016_j_ejmg_2017_07_012 crossref_primary_10_1371_journal_pone_0065141 crossref_primary_10_1097_SLA_0000000000003580 crossref_primary_10_1016_j_bjorl_2024_101409 crossref_primary_10_1158_1078_0432_CCR_17_0631 crossref_primary_10_1016_S0084_3741_09_79343_6 crossref_primary_10_1016_j_mcna_2012_01_010 crossref_primary_10_1586_era_09_92 crossref_primary_10_3389_fendo_2021_727970 crossref_primary_10_1016_S0873_2159_15_30195_1 crossref_primary_10_3390_ijms24097843 crossref_primary_10_1245_s10434_021_09745_x |
| Cites_doi | 10.1002/j.1460-2075.1990.tb07574.x 10.1245/s10434-006-9207-5 10.1210/me.2007-0269 10.1016/j.tem.2005.07.003 10.1016/j.jpeds.2004.04.011 10.1093/hmg/11.8.971 10.1677/erc.1.01138 10.1002/jso.20692 10.1101/gad.10.1.60 10.1093/hmg/ddi015 10.1093/nar/15.20.8149 10.1074/jbc.270.44.26649 10.1089/thy.2005.15.588 10.1016/j.ejso.2003.10.021 10.1097/01.ruq.0000226877.19937.a1 10.1038/nrc1097 10.1002/j.1460-2075.1989.tb08391.x 10.1677/ERC-07-0214 10.1097/01.sla.0000250445.92336.2a 10.1210/endo.140.6.6759 10.1056/NEJM199804303381817 10.1074/jbc.M304885200 10.1007/s00268-002-6615-y 10.1038/nature00766 10.1111/j.1469-1809.2007.00403.x 10.1016/S0092-8674(00)81959-5 10.1023/A:1008907227706 10.1128/MCB.11.10.4927 10.1007/s00428-006-0187-4 10.1007/s002680010233 10.1007/s00268-008-9484-1 10.1007/s00268-005-0363-8 10.1067/mpd.2000.107111 10.1128/MCB.10.12.6216 10.1074/jbc.271.4.2249 10.1128/MCB.12.2.576 10.1016/S0140-6736(03)12488-9 10.1001/archsurg.1995.01430080094015 10.1210/jcem.82.2.3789 10.1210/jc.2007-1717 10.1210/jc.2008-0273 10.1210/jc.2005-1497 10.1074/jbc.M203188200 10.1210/me.2005-0327 10.1074/jbc.270.20.12048 |
| ContentType | Journal Article |
| Copyright | The Author 2009. Published by Oxford University Press. 2009 2009 INIST-CNRS The Author 2009. Published by Oxford University Press. |
| Copyright_xml | – notice: The Author 2009. Published by Oxford University Press. 2009 – notice: 2009 INIST-CNRS – notice: The Author 2009. Published by Oxford University Press. |
| DBID | BSCLL AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7TO 7U7 7U9 C1K H94 K9. NAPCQ 7TM 7U1 8FD FR3 P64 RC3 7X8 |
| DOI | 10.1093/jnci/djn471 |
| DatabaseName | Istex CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Oncogenes and Growth Factors Abstracts Toxicology Abstracts Virology and AIDS Abstracts Environmental Sciences and Pollution Management AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Premium Nucleic Acids Abstracts Risk Abstracts Technology Research Database Engineering Research Database Biotechnology and BioEngineering Abstracts Genetics Abstracts MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Nursing & Allied Health Premium Virology and AIDS Abstracts Oncogenes and Growth Factors Abstracts Toxicology Abstracts AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) Environmental Sciences and Pollution Management Risk Abstracts Genetics Abstracts Technology Research Database Nucleic Acids Abstracts Engineering Research Database Biotechnology and BioEngineering Abstracts MEDLINE - Academic |
| DatabaseTitleList | Nursing & Allied Health Premium Risk Abstracts MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1460-2105 |
| EndPage | 175 |
| ExternalDocumentID | 1644398851 19176457 21218109 10_1093_jnci_djn471 10.1093/jnci/djn471 ark_67375_HXZ_CDXWSWH3_G |
| Genre | Research Support, Non-U.S. Gov't Journal Article Case Reports |
| GroupedDBID | --- -DD -E4 -~X .2P .55 .GJ .I3 .XZ .ZR 08P 0R~ 186 1TH 29L 2QL 2WC 354 3O- 4.4 482 48X 53G 5GY 5RE 5VS 5WD 70D 8WZ 96U A6W AABZA AACZT AAGKA AAHTB AAJKP AAJQQ AAKAS AAMVS AAOGV AAPGJ AAPNW AAPQZ AAPXW AAQQT AARHZ AAUAY AAUQX AAVAP AAWDT AAWTL ABCQX ABDFA ABEFU ABEJV ABEUO ABGNP ABIXL ABJNI ABKDP ABNGD ABNHQ ABNKS ABOCM ABPEJ ABPMR ABPPZ ABPTD ABQLI ABQNK ABSMQ ABVGC ABXVV ABZBJ ACBMB ACFRR ACGFO ACGFS ACGOD ACKOT ACNCT ACPQN ACPRK ACUFI ACUKT ACUTJ ACUTO ACVCV ACYHN ACZBC ADBBV ADEYI ADEZT ADGZP ADHKW ADHZD ADIPN ADMTO ADNBA ADOCK ADQBN ADRTK ADVEK ADXHL ADYVW ADZCM AEGPL AEHUL AEJOX AEKPW AEKSI AEMDU AEMQT AENZO AEPUE AETBJ AETEA AEWNT AFAZI AFCHL AFFNX AFFQV AFFZL AFIYH AFOFC AFRAH AFSHK AFXAL AFYAG AGINJ AGKEF AGKRT AGMDO AGNAY AGORE AGQPQ AGSYK AGUTN AHGBF AHMBA AHMMS AHXPO AI. AIAGR AIJHB AJBYB AJDVS AJEEA AJNCP ALMA_UNASSIGNED_HOLDINGS ALUQC ALXQX APIBT APJGH APWMN AQDSO AQKUS ASPBG ATGXG ATTQO AVNTJ AVWKF AZFZN BAWUL BAYMD BCRHZ BEYMZ BKOMP BSCLL BTRTY BVRKM BZKNY C45 CAG CDBKE COF CS3 CZ4 DAKXR DIK DILTD DU5 D~K E3Z EBS EE~ EIHJH EJD EMOBN ENERS F5P F8P F9B FA8 FECEO FEDTE FLUFQ FOEOM FOTVD FQBLK GAUVT GJXCC GOZPB GRPMH GX1 H13 H5~ HAR HVGLF HW0 HZ~ IH2 IOX J21 J5H JXSIZ KAQDR KBUDW KOP KQ8 KSI KSN L7B LXL LXN LXY M-Z MBLQV MHKGH ML0 MVM N9A NGC NOMLY NOYVH NTWIH NU- NVLIB O0~ OAUYM OAWHX OBFPC OBH OCB OCZFY ODMLO ODZKP OGEVE OHH OJQWA OJZSN OK1 OPAEJ OVD OWPYF O~Y P2P PAFKI PB- PEELM PQQKQ Q.- Q1. Q5Y QBD R44 RD5 RNI RNS ROL ROX ROZ RUSNO RW1 RXO RZF RZO TCURE TEORI TJX TMA TR2 TWZ UDS UPT VH1 VVN W8F WH7 WOQ X7H X7M XJT Y6R YAYTL YHZ YKOAZ YQT YR5 YXANX ZKX ZRR ZY1 ~91 ~H1 ~X8 AASNB ABQTQ ADJQC ADRIX ADZXQ M49 RHF AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7TO 7U7 7U9 C1K H94 K9. NAPCQ 7TM 7U1 8FD FR3 P64 RC3 7X8 |
| ID | FETCH-LOGICAL-c444t-9f6a4b9020e2c560be6a9dcdc8913e91cc41ae5f327b99648b3e542f5b3f29b43 |
| ISSN | 0027-8874 1460-2105 |
| IngestDate | Fri Jul 11 07:59:35 EDT 2025 Fri Jul 11 13:31:58 EDT 2025 Mon Jun 30 08:50:38 EDT 2025 Mon Jul 21 05:45:36 EDT 2025 Mon Jul 21 09:17:21 EDT 2025 Tue Jul 01 01:42:07 EDT 2025 Thu Apr 24 22:51:08 EDT 2025 Wed Sep 11 04:51:26 EDT 2024 Tue Aug 05 16:48:16 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 3 |
| Keywords | Endocrinopathy Nodular goiter Human Endocrine gland Thyroid diseases Thyroid gland Malignant tumor Signal transduction Cancerology Germ line Genetics Mutation Transcription factor Papillary thyroid carcinoma Cancer |
| Language | English |
| License | CC BY 4.0 |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c444t-9f6a4b9020e2c560be6a9dcdc8913e91cc41ae5f327b99648b3e542f5b3f29b43 |
| Notes | ark:/67375/HXZ-CDXWSWH3-G istex:7EB54B09BEE1007C0E0E13186449BF75DF9027FA ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 14 ObjectType-Report-3 ObjectType-Case Study-4 ObjectType-Article-1 ObjectType-Feature-2 content type line 23 ObjectType-Case Study-2 ObjectType-Feature-4 ObjectType-Report-1 ObjectType-Article-3 |
| PMID | 19176457 |
| PQID | 221034152 |
| PQPubID | 41605 |
| PageCount | 14 |
| ParticipantIDs | proquest_miscellaneous_66905372 proquest_miscellaneous_20456140 proquest_journals_221034152 pubmed_primary_19176457 pascalfrancis_primary_21218109 crossref_citationtrail_10_1093_jnci_djn471 crossref_primary_10_1093_jnci_djn471 oup_primary_10_1093_jnci_djn471 istex_primary_ark_67375_HXZ_CDXWSWH3_G |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2009-02-04 |
| PublicationDateYYYYMMDD | 2009-02-04 |
| PublicationDate_xml | – month: 02 year: 2009 text: 2009-02-04 day: 04 |
| PublicationDecade | 2000 |
| PublicationPlace | Cary, NC |
| PublicationPlace_xml | – name: Cary, NC – name: United States – name: Oxford |
| PublicationTitle | JNCI : Journal of the National Cancer Institute |
| PublicationTitleAlternate | J Natl Cancer Inst |
| PublicationYear | 2009 |
| Publisher | Oxford University Press Oxford Publishing Limited (England) |
| Publisher_xml | – name: Oxford University Press – name: Oxford Publishing Limited (England) |
| References | Grossman ( key 20170520221639_bib3) 1995; 130 Rios ( key 20170520221639_bib38) 2004; 30 Guazzi ( key 20170520221639_bib12) 1990; 9 De Felice ( key 20170520221639_bib49) 1995; 270 Arnone ( key 20170520221639_bib48) 1995; 270 DeFelice ( key 20170520221639_bib13) 2003; 278 Abubaker ( key 20170520221639_bib45) 2008; 93 Mizuno ( key 20170520221639_bib18) 1991; 11 Kim ( key 20170520221639_bib43) 2007; 21 Sherman ( key 20170520221639_bib2) 2003; 361 Uchino ( key 20170520221639_bib4) 2002; 26 Li ( key 20170520221639_bib36) 2002; 277 Moya ( key 20170520221639_bib25) 2006; 91 Cavaco ( key 20170520221639_bib10) 2008; 15 Frates ( key 20170520221639_bib28) 2006; 22 Liu ( key 20170520221639_bib46) 2008; 93 Francis-Lang ( key 20170520221639_bib16) 1992; 12 DeLellis ( key 20170520221639_bib29) Doyle ( key 20170520221639_bib23) 2004; 145 Kikkawa ( key 20170520221639_bib17) 1990; 10 Lang ( key 20170520221639_bib30) 2007; 14 Musti ( key 20170520221639_bib15) 1987; 15 Moore ( key 20170520221639_bib40) 2006; 94 Trovato ( key 20170520221639_bib44) 2003; 18 Breedveld ( key 20170520221639_bib47) 2002; 11 Lang ( key 20170520221639_bib1) 2007; 245 Sturgeon ( key 20170520221639_bib11) 2005; 15 Kusakabe ( key 20170520221639_bib21) 2006; 20 Pucci ( key 20170520221639_bib8) 2006; 448 Garcia-Barcelo ( key 20170520221639_bib32) 2008; 72 Malumbres ( key 20170520221639_bib33) 2003; 3 Kimura ( key 20170520221639_bib35) 2003; 63 Bakhsh ( key 20170520221639_bib9) 2006; 13 Devriendt ( key 20170520221639_bib22) 1998; 338 Lo ( key 20170520221639_bib41) 2006; 30 Civitareale ( key 20170520221639_bib19) 1993; 7 Zannini ( key 20170520221639_bib50) 1996; 271 Arora ( key 20170520221639_bib7) 2008; 32 Garcia-Barcelo ( key 20170520221639_bib31) 2005; 14 Burgess ( key 20170520221639_bib5) 1997; 82 Ngan ( key 20170520221639_bib37) 1999; 140 Fabbro ( key 20170520221639_bib26) 1994; 54 Iwatani ( key 20170520221639_bib24) 2000; 137 Bromberg ( key 20170520221639_bib42) 1999; 98 Musholt ( key 20170520221639_bib6) 2000; 24 Civitareale ( key 20170520221639_bib14) 1989; 8 Davies ( key 20170520221639_bib34) 2002; 417 Franceschi ( key 20170520221639_bib27) 1999; 10 Bottcher ( key 20170520221639_bib39) 2005; 16 Kimura ( key 20170520221639_bib20) 1996; 10 |
| References_xml | – volume: 9 start-page: 3631 issue: 11 year: 1990 ident: key 20170520221639_bib12 article-title: Thyroid nuclear factor 1 (TTF-1) contains a homeodomain and displays a novel DNA binding specificity publication-title: Embo J doi: 10.1002/j.1460-2075.1990.tb07574.x – volume: 14 start-page: 730 issue: 2 year: 2007 ident: key 20170520221639_bib30 article-title: Prognostic factors in papillary and follicular thyroid carcinoma: their implications for cancer staging publication-title: Ann Surg Oncol doi: 10.1245/s10434-006-9207-5 – volume: 21 start-page: 3039 issue: 12 year: 2007 ident: key 20170520221639_bib43 article-title: Tumor suppressor LKB1 inhibits activation of signal transducer and activator of transcription 3 (STAT3) by thyroid oncogenic tyrosine kinase rearranged in transformation (RET)/papillary thyroid carcinoma (PTC) publication-title: Mol Endocrinol doi: 10.1210/me.2007-0269 – volume: 16 start-page: 314 issue: 7 year: 2005 ident: key 20170520221639_bib39 article-title: The genetics of euthyroid familial goiter publication-title: Trends Endocrinol Metab doi: 10.1016/j.tem.2005.07.003 – volume: 145 start-page: 190 issue: 2 year: 2004 ident: key 20170520221639_bib23 article-title: Autosomal dominant transmission of congenital hypothyroidism, neonatal respiratory distress, and ataxia caused by a mutation of NKX2-1 publication-title: J Pediatr doi: 10.1016/j.jpeds.2004.04.011 – volume: 11 start-page: 971 issue: 8 year: 2002 ident: key 20170520221639_bib47 article-title: Mutations in TITF-1 are associated with benign hereditary chorea publication-title: Hum Mol Genet. doi: 10.1093/hmg/11.8.971 – volume: 13 start-page: 475 issue: 2 year: 2006 ident: key 20170520221639_bib9 article-title: A new form of familial multi-nodular goitre with progression to differentiated thyroid cancer publication-title: Endocr Relat Cancer doi: 10.1677/erc.1.01138 – volume: 94 start-page: 719 issue: 8 year: 2006 ident: key 20170520221639_bib40 article-title: Inherited aspects of papillary thyroid carcinoma publication-title: J Surg Oncol doi: 10.1002/jso.20692 – volume: 10 start-page: 60 issue: 1 year: 1996 ident: key 20170520221639_bib20 article-title: The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary publication-title: Genes Dev. doi: 10.1101/gad.10.1.60 – volume: 18 start-page: 393 issue: 2 year: 2003 ident: key 20170520221639_bib44 article-title: Distinctive expression of STAT3 in papillary thyroid carcinomas and a subset of follicular adenomas publication-title: Histol Histopathol – volume: 14 start-page: 191 issue: 2 year: 2005 ident: key 20170520221639_bib31 article-title: TTF-1 and RET promoter SNPs: regulation of RET transcription in Hirschsprung's disease publication-title: Hum Mol Genet. doi: 10.1093/hmg/ddi015 – volume: 15 start-page: 8149 issue: 20 year: 1987 ident: key 20170520221639_bib15 article-title: A cell type specific factor recognizes the rat thyroglobulin promoter publication-title: Nucleic Acids Res. doi: 10.1093/nar/15.20.8149 – volume: 7 start-page: 1589 issue: 12 year: 1993 ident: key 20170520221639_bib19 article-title: Thyroid transcription factor 1 activates the promoter of the thyrotropin receptor gene publication-title: Mol Endocrinol – volume: 270 start-page: 26649 issue: 44 year: 1995 ident: key 20170520221639_bib49 article-title: Redundant domains contribute to the transcriptional activity of the thyroid transcription factor 1 publication-title: J Biol Chem. doi: 10.1074/jbc.270.44.26649 – volume: 15 start-page: 588 issue: 6 year: 2005 ident: key 20170520221639_bib11 article-title: Familial nonmedullary thyroid cancer publication-title: Thyroid doi: 10.1089/thy.2005.15.588 – volume-title: World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of Endocrine Organs ident: key 20170520221639_bib29 – volume: 30 start-page: 58 issue: 1 year: 2004 ident: key 20170520221639_bib38 article-title: Risk factors for malignancy in multinodular goiters publication-title: Eur J Surg Oncol doi: 10.1016/j.ejso.2003.10.021 – volume: 22 start-page: 231 issue: 4 year: 2006 ident: key 20170520221639_bib28 article-title: Management of thyroid nodules detected at US: Society of Radiologists in Ultrasound consensus conference statement publication-title: Ultrasound Q doi: 10.1097/01.ruq.0000226877.19937.a1 – volume: 3 start-page: 459 issue: 6 year: 2003 ident: key 20170520221639_bib33 article-title: RAS oncogenes: the first 30 years publication-title: Nat Rev Cancer doi: 10.1038/nrc1097 – volume: 8 start-page: 2537 issue: 9 year: 1989 ident: key 20170520221639_bib14 article-title: A thyroid-specific nuclear protein essential for tissue-specific expression of the thyroglobulin promoter publication-title: EMBO J doi: 10.1002/j.1460-2075.1989.tb08391.x – volume: 15 start-page: 207 issue: 1 year: 2008 ident: key 20170520221639_bib10 article-title: Familial non-medullary thyroid carcinoma (FNMTC): analysis of fPTC/PRN, NMTC1, MNG1 and TCO susceptibility loci and identification of somatic BRAF and RAS mutations publication-title: Endocr Relat Cancer doi: 10.1677/ERC-07-0214 – volume: 245 start-page: 366 issue: 3 year: 2007 ident: key 20170520221639_bib1 article-title: Staging systems for papillary thyroid carcinoma: a review and comparison publication-title: Ann Surg doi: 10.1097/01.sla.0000250445.92336.2a – volume: 63 start-page: 1454 issue: 7 year: 2003 ident: key 20170520221639_bib35 article-title: High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma publication-title: Cancer Res. – volume: 140 start-page: 2452 issue: 6 year: 1999 ident: key 20170520221639_bib37 article-title: Steroidogenic factor-1 interacts with a gonadotrope-specific element within the first exon of the human gonadotropin-releasing hormone receptor gene to mediate gonadotrope-specific expression publication-title: Endocrinology doi: 10.1210/endo.140.6.6759 – volume: 338 start-page: 1317 issue: 18 year: 1998 ident: key 20170520221639_bib22 article-title: Deletion of thyroid transcription factor-1 gene in an infant with neonatal thyroid dysfunction and respiratory failure publication-title: N Engl J Med doi: 10.1056/NEJM199804303381817 – volume: 278 start-page: 35574 issue: 37 year: 2003 ident: key 20170520221639_bib13 article-title: TTF-1 phosphorylation is required for peripheral lung morphogenesis, perinatal survival, and tissue-specific gene expression publication-title: J Biol Chem. doi: 10.1074/jbc.M304885200 – volume: 26 start-page: 897 issue: 8 year: 2002 ident: key 20170520221639_bib4 article-title: Familial nonmedullary thyroid carcinoma characterized by multifocality and a high recurrence rate in a large study population publication-title: World J Surg doi: 10.1007/s00268-002-6615-y – volume: 417 start-page: 949 issue: 6892 year: 2002 ident: key 20170520221639_bib34 article-title: Mutations of the BRAF gene in human cancer publication-title: Nature doi: 10.1038/nature00766 – volume: 72 start-page: 170 issue: pt 2 year: 2008 ident: key 20170520221639_bib32 article-title: Evaluation of the NK2 homeobox 1 gene (NKX2-1) as a Hirschsprung's disease locus publication-title: Ann Hum Genet. doi: 10.1111/j.1469-1809.2007.00403.x – volume: 98 start-page: 295 issue: 3 year: 1999 ident: key 20170520221639_bib42 article-title: Stat3 as an oncogene publication-title: Cell. doi: 10.1016/S0092-8674(00)81959-5 – volume: 10 start-page: 583 issue: 6 year: 1999 ident: key 20170520221639_bib27 article-title: A pooled analysis of case-control studies of thyroid cancer. IV. Benign thyroid diseases publication-title: Cancer Causes Control doi: 10.1023/A:1008907227706 – volume: 11 start-page: 4927 issue: 10 year: 1991 ident: key 20170520221639_bib18 article-title: Thyroid-specific enhancer-binding protein (T/EBP): cDNA cloning, functional characterization, and structural identity with thyroid transcription factor TTF-1 publication-title: Mol Cell Biol. doi: 10.1128/MCB.11.10.4927 – volume: 448 start-page: 857 issue: 6 year: 2006 ident: key 20170520221639_bib8 article-title: Papillary thyroid carcinoma presenting as a solitary soft tissue arm metastasis in an elderly hyperthyroid patient. Case report and review of the literature publication-title: Virchows Arch. doi: 10.1007/s00428-006-0187-4 – volume: 24 start-page: 1409 issue: 11 year: 2000 ident: key 20170520221639_bib6 article-title: Familial papillary thyroid carcinoma: genetics, criteria for diagnosis, clinical features, and surgical treatment publication-title: World J Surg doi: 10.1007/s002680010233 – volume: 32 start-page: 1237 issue: 7 year: 2008 ident: key 20170520221639_bib7 article-title: Fahey TJ III. Do benign thyroid nodules have malignant potential? An evidence-based review publication-title: World J Surg doi: 10.1007/s00268-008-9484-1 – volume: 30 start-page: 759 issue: 5 year: 2006 ident: key 20170520221639_bib41 article-title: Papillary microcarcinoma: is there any difference between clinically overt and occult tumors? publication-title: World J Surg doi: 10.1007/s00268-005-0363-8 – volume: 137 start-page: 272 issue: 2 year: 2000 ident: key 20170520221639_bib24 article-title: Deletion of NKX2.1 gene encoding thyroid transcription factor-1 in two siblings with hypothyroidism and respiratory failure publication-title: J Pediatr doi: 10.1067/mpd.2000.107111 – volume: 10 start-page: 6216 issue: 12 year: 1990 ident: key 20170520221639_bib17 article-title: Characterization of a thyroid-specific enhancer located 5.5 kilobase pairs upstream of the human thyroid peroxidase gene publication-title: Mol Cell Biol. doi: 10.1128/MCB.10.12.6216 – volume: 271 start-page: 2249 issue: 4 year: 1996 ident: key 20170520221639_bib50 article-title: Mapping and functional role of phosphorylation sites in the thyroid transcription factor-1 (TTF-1) publication-title: J Biol Chem. doi: 10.1074/jbc.271.4.2249 – volume: 12 start-page: 576 issue: 2 year: 1992 ident: key 20170520221639_bib16 article-title: Cell-type-specific expression of the rat thyroperoxidase promoter indicates common mechanisms for thyroid-specific gene expression publication-title: Mol Cell Biol. doi: 10.1128/MCB.12.2.576 – volume: 54 start-page: 4744 issue: 17 year: 1994 ident: key 20170520221639_bib26 article-title: Expression of thyroid-specific transcription factors TTF-1 and PAX-8 in human thyroid neoplasms publication-title: Cancer Res. – volume: 361 start-page: 501 issue: 9356 year: 2003 ident: key 20170520221639_bib2 article-title: Thyroid carcinoma publication-title: Lancet doi: 10.1016/S0140-6736(03)12488-9 – volume: 130 start-page: 892 issue: 8 year: 1995 ident: key 20170520221639_bib3 article-title: Familial nonmedullary thyroid cancer. An emerging entity that warrants aggressive treatment publication-title: Arch Surg doi: 10.1001/archsurg.1995.01430080094015 – volume: 82 start-page: 345 issue: 2 year: 1997 ident: key 20170520221639_bib5 article-title: Two families with an autosomal dominant inheritance pattern for papillary carcinoma of the thyroid publication-title: J Clin Endocrinol Metab doi: 10.1210/jcem.82.2.3789 – volume: 93 start-page: 611 issue: 2 year: 2008 ident: key 20170520221639_bib45 article-title: Clinicopathological analysis of papillary thyroid cancer with PIK3CA alterations in a Middle Eastern population publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2007-1717 – volume: 93 start-page: 3106 issue: 8 year: 2008 ident: key 20170520221639_bib46 article-title: Highly prevalent genetic alterations in receptor tyrosine kinases and PI3K/Akt and MAP kinase pathways in anaplastic and follicular thyroid cancers publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2008-0273 – volume: 91 start-page: 1832 issue: 5 year: 2006 ident: key 20170520221639_bib25 article-title: Functional study of a novel single deletion in the TITF1/NKX2.1 homeobox gene that produces congenital hypothyroidism and benign chorea but not pulmonary distress publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2005-1497 – volume: 277 start-page: 38399 issue: 41 year: 2002 ident: key 20170520221639_bib36 article-title: Transforming growth factor-beta inhibits pulmonary surfactant protein B gene transcription through SMAD3 interactions with NKX2.1 and HNF-3 transcription factors publication-title: J Biol Chem. doi: 10.1074/jbc.M203188200 – volume: 20 start-page: 1796 issue: 8 year: 2006 ident: key 20170520221639_bib21 article-title: Thyroid-specific enhancer-binding protein/NKX2.1 is required for the maintenance of ordered architecture and function of the differentiated thyroid publication-title: Mol Endocrinol doi: 10.1210/me.2005-0327 – volume: 270 start-page: 12048 issue: 20 year: 1995 ident: key 20170520221639_bib48 article-title: The DNA binding activity and the dimerization ability of the thyroid transcription factor I are redox regulated publication-title: J Biol Chem. doi: 10.1074/jbc.270.20.12048 |
| SSID | ssj0000924 |
| Score | 2.286513 |
| Snippet | Background The genetic factors that determine the risk of papillary thyroid carcinoma (PTC) among patients with multinodular goiter (MNG) remain undefined.... Background The genetic factors that determine the risk of papillary thyroid carcinoma (PTC) among patients with multinodular goiter (MNG) remain undefined.... The genetic factors that determine the risk of papillary thyroid carcinoma (PTC) among patients with multinodular goiter (MNG) remain undefined. Because... Background: The genetic factors that determine the risk of papillary thyroid carcinoma (PTC) among patients with multinodular goiter (MNG) remain undefined.... |
| SourceID | proquest pubmed pascalfrancis crossref oup istex |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 162 |
| SubjectTerms | Adolescent Adult Aged Aged, 80 and over Alanine Animals Biological and medical sciences Carcinoma, Papillary - genetics Carcinoma, Papillary - metabolism Carcinoma, Papillary - pathology Case-Control Studies Cell Proliferation Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Child Electrophoretic Mobility Shift Assay Endocrinopathies Female Gene Expression Regulation, Neoplastic Germ-Line Mutation Goiter, Nodular - genetics Goiter, Nodular - metabolism Goiter, Nodular - pathology Head & neck cancer Humans Immunoblotting Luciferases Male Medical sciences Middle Aged Mutation Neoplasm Staging Non tumoral diseases. Target tissue resistance. Benign neoplasms Nuclear Proteins - genetics Nuclear Proteins - metabolism Oncology Pathology Rats Reverse Transcriptase Polymerase Chain Reaction Signal Transduction - genetics Thyroid diseases Thyroid Gland - cytology Thyroid Gland - metabolism Thyroid Neoplasms - genetics Thyroid Neoplasms - metabolism Thyroid Neoplasms - pathology Thyroid Nuclear Factor 1 Thyroid. Thyroid axis (diseases) Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic Tumors Up-Regulation Valine Young Adult |
| Title | A Germline Mutation (A339V) in Thyroid Transcription Factor-1 (TITF-1/NKX2.1) in Patients With Multinodular Goiter and Papillary Thyroid Carcinoma |
| URI | https://api.istex.fr/ark:/67375/HXZ-CDXWSWH3-G/fulltext.pdf https://www.ncbi.nlm.nih.gov/pubmed/19176457 https://www.proquest.com/docview/221034152 https://www.proquest.com/docview/20456140 https://www.proquest.com/docview/66905372 |
| Volume | 101 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Zb9NAEF6VVkJICHETCmUfKlSI3Mb2-tjHkB4pTQMSKY14sez1uk2pnCp1JMrP4Bczs4eTiLYCXizLXnvizOe5PAch64EbgWL2I0eIPHaYFIXD08h1XLA2gjySPFd9ug_7YfeIfRwGw6U7ZC5raVplm-LntXUl_8NVOAZ8xSrZf-BsfVM4APvAX9gCh2H7VzxuN_dAsCpD8XBaWVbGbd_nX9HdH5XNwenVZDzKdRPzWkLsqik7jourB_vwLCjP-gdDb9M1133W_VYxPbY6baoy3XKcq5zVvTGWLesyg_QCpxZNrmo6HZxNVI6NtLdWb7-zr2IPc-avSq60kcgOYm8yy1yoQ9QnOj67c34OMq5Zx4N6Jsr9YYLyqTursOiNphqB5UlllbJqQKnHOWO941XzwCgdG-zgKj96Fuw0RZRzETpTBoZ_l5l6YiMotlgBlHCsBwFtSi3jWdhywNMNFpSACamM5oMESqS7Wlv8oWp0G66zUiBM8rOS6VEyiy29-5-S3aNeLxnsDAeLZ7UHBtaoz-MYewCseODo4AyO7f2DmS3BPdNHXD-GqTAF2ltIeUvTXbCpVlA8_LD1mvcv0kt42Qs9peVmN0qZU4OH5IEBAm1rUD8iS7J8TO4emkyPJ-RXm1psU4ttuqGQ_Y6OSmrwRhdwTS2u6YZG9ZbGtLrCIpoiouk8oqlGNAW20hrRNYUa0U_J0e7OoNN1zPwQRzDGKocXYcoyDg6R9ARY9pkMU56LXOCnecldIZibyqDwvSgDt5_FmS8D5hVB5hcez5j_jCyX41K-IDT3RCvlXiHA22dCFjHs5iDPWszNikzKBnlvOZAI01wfZ7ycJzrJw0-QXYlmV4Os14svdE-Z65e9Vays16ST75iGGQVJd_gt6WwPj78cd_1kr0HeAK9vv9XaAg7qtWC4gonf4g2yaoGRGAF3mXjwkvho4AOB-ixoH_ykmJZyPIUl6BG6rHXzijDk2DIK7vFc4232O7kbhSyIXt5Ke5XcmwmCV2S5mkzla_ADqmxNvSq_AdwfBhg |
| linkProvider | Flying Publisher |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+Germline+Mutation+%28A339V%29+in+Thyroid+Transcription+Factor-1+%28TITF-1%2FNKX2.1%29+in+Patients+With+Multinodular+Goiter+and+Papillary+Thyroid+Carcinoma&rft.jtitle=JNCI+%3A+Journal+of+the+National+Cancer+Institute&rft.au=Ngan%2C+Elly+S+W&rft.au=Lang%2C+Brian+H+H&rft.au=Liu%2C+Tingting&rft.au=Shum%2C+Cathy+K+Y&rft.date=2009-02-04&rft.pub=Oxford+Publishing+Limited+%28England%29&rft.issn=0027-8874&rft.eissn=1460-2105&rft.volume=101&rft.issue=3&rft.spage=162&rft_id=info:doi/10.1093%2Fjnci%2Fdjn471&rft.externalDBID=NO_FULL_TEXT&rft.externalDocID=1644398851 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0027-8874&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0027-8874&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0027-8874&client=summon |