Significance of serum Zn-α2-glycoprotein for the regulation of blood pressure

• Published in: Hypertension research Vol. 38; no. 4; pp. 244 - 251
• Main Authors: Kurita, Souichi, Takeuchi, Keisuke, Hayashi, Yoshimi, Ueyama, Hisao, Zankov, Dimitar P, Pang, Xiaoling, Otsuka, Takanobu, Ohkubo, Iwao, Ogikubo, Osamu, Ogita, Hisakazu
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.04.2015
• Subjects: Adolescent; Adult; Aged; Animals; Blood pressure; Blood Pressure - genetics; Blood Pressure - physiology; Cell Line; Female; Gene expression; Gene Expression Regulation; Gene Knockdown Techniques; Glycoproteins; Humans; Hypertension; Hypertension - genetics; Hypertension - physiopathology; Male; Metabolic Syndrome - blood; Metabolism; Middle Aged; Muscle Tonus - genetics; Promoter Regions, Genetic - genetics; Rats; rhoA GTP-Binding Protein - genetics; rhoA GTP-Binding Protein - metabolism; Seminal Plasma Proteins - biosynthesis; Seminal Plasma Proteins - blood; Seminal Plasma Proteins - genetics; Sp1 Transcription Factor - genetics; Sp1 Transcription Factor - physiology; Young Adult
• ISSN: 0916-9636; 1348-4214; 1348-4214
• DOI: 10.1038/hr.2014.165

Zn-α2-glycoprotein (ZAG) (molecular weight=41 kDa) is one component in the α2 fraction of human plasma, and is reported to be associated with several diseases, such as cancers and metabolic syndromes. ZAG is also considered to be an important modulator of lipid metabolism. However, little is known a...