A Gene-Expression Predictor for Efficacy of Induction Chemotherapy in Locoregionally Advanced Nasopharyngeal Carcinoma

• Published in: JNCI : Journal of the National Cancer Institute Vol. 113; no. 4; pp. 471 - 480
• Main Authors: Lei, Yuan, Li, Ying-Qin, Jiang, Wei, Hong, Xiao-Hong, Ge, Wen-Xiu, Zhang, Yuan, Hu, Wei-Han, Wang, Ya-Qin, Liang, Ye-Lin, Li, Jun-Yan, Cho, William C S, Yun, Jing-Ping, Zeng, Jing, Chen, Jie-Wei, Liu, Li-Zhi, Li, Li, Chen, Lei, Xie, Fang-Yun, Li, Wen-Fei, Mao, Yan-Ping, Liu, Xu, Chen, Yu-Pei, Tang, Ling-Long, Sun, Ying, Liu, Na, Ma, Jun
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 06.04.2021; Oxford Publishing Limited (England)
• Subjects: Cancer; Chemoradiotherapy; Chemotherapy; Clinical trials; Confidence intervals; DNA microarrays; Gene expression; Genes; Nasopharyngeal carcinoma; Patients; Radiation therapy; Sensitivity; Statistical analysis; Survival; Throat cancer; Toxicity; Training; Tumors

Abstract Background Induction chemotherapy (IC) followed by concurrent chemoradiotherapy is the mainstay treatment for patients with locoregionally advanced nasopharyngeal carcinoma. However, some patients obtain little benefit and experience unnecessary toxicities from IC. We intended to develop a...