Primary open-angle glaucoma genes

• Published in: Eye (London) Vol. 25; no. 5; pp. 587 - 595
• Main Author: Fingert, J H
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.05.2011; Nature Publishing Group
• Subjects: 631/208/737; 692/499; 692/699; Acetyltransferases - genetics; Caveolins - genetics; Cytoskeletal Proteins - genetics; Eye Proteins - genetics; Glaucoma; Glaucoma, Open-Angle - genetics; Glycoproteins - genetics; Humans; Laboratory Medicine; Medicine; Medicine & Public Health; Mutation; Ophthalmology; Pharmaceutical Sciences/Technology; Protein-Serine-Threonine Kinases - genetics; Review; Ribonucleoproteins - genetics; Surgery; Surgical Oncology; Transcription Factor TFIIIA - genetics; POAG; glaucoma; genetics

A substantial fraction of glaucoma has a genetic basis. About 5% of primary open angle glaucoma (POAG) is currently attributed to single-gene or Mendelian forms of glaucoma (ie glaucoma caused by mutations in myocilin or optineurin ). Mutations in these genes have a high likelihood of leading to gla...