XIAP as a ubiquitin ligase in cellular signaling

• Published in: Cell death and differentiation Vol. 17; no. 1; pp. 54 - 60
• Main Authors: Galbán, S, Duckett, C S
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.01.2010; Nature Publishing Group
• Subjects: Apoptosis; Biochemistry; Biomedical and Life Sciences; Cell Biology; Cell Cycle Analysis; Cell death; Inhibitor of Apoptosis Proteins - metabolism; Internal medicine; Kinases; Life Sciences; NF-kappa B - metabolism; Physiology; Proteins; review; Signal Transduction; Stem Cells; Tumor necrosis factor-TNF; Ubiquitin-Protein Ligases - metabolism; X-Linked Inhibitor of Apoptosis Protein - metabolism; X-Linked Inhibitor of Apoptosis Protein - physiology; Ann Arbor Michigan; United States > US; XIAP; c-IAPs; E3 ubiquitin ligase; RING; NF-kB

The ability of the vertebrate X-linked inhibitor of apoptosis (XIAP) protein to directly suppress apoptotic cell death pathways has been the subject of much research. Studies of this broadly expressed protein have largely focused on the unique interactions between XIAP and caspases – proteases that...