IgE repertoire and immunological memory: compartmental regulation and antibody function

• Published in: International immunology Vol. 30; no. 9; pp. 403 - 412
• Main Authors: Gould, Hannah J, Wu, Yu-Chang Bryan
• Format: Journal Article
• Language: English
• Published: UK Oxford University Press 30.08.2018
• Subjects: Animals; Antibodies - immunology; Antigen-Antibody Reactions; Antigens - immunology; Humans; Immunoglobulin E - immunology; Immunologic Memory - immunology; Invited Reviews; Plasma Cells - immunology; Receptors, IgE - immunology; allergy; IgE repertoire; next-generation sequencing; mucosa; immunological memory

Abstract It is now generally recognized that bone marrow is the survival niche for antigen-specific plasma cells with long-term immunological memory. These cells release antibodies into the circulation, needed to prime effector cells in the secondary immune response. These antibodies participate in...