IGFBP7 plays a potential tumor suppressor role in colorectal carcinogenesis
Insulin-like growth factor binding protein-7 (IGFBP7) is a gene identified as being low expressed in colorectal adenocarcinoma (CRC) cell lines. In the current study, we investigated the function of IGFBP7 in CRC by transfection studies. We found that IGFBP7 could inhibit cell growth, decrease soft...
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| Published in | Cancer biology & therapy Vol. 6; no. 3; pp. 354 - 359 |
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| Main Authors | , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Taylor & Francis
01.03.2007
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Insulin-like growth factor binding protein-7 (IGFBP7) is a gene identified as being low expressed in colorectal adenocarcinoma (CRC) cell lines. In the current study, we investigated the function of IGFBP7 in CRC by transfection studies. We found that IGFBP7 could inhibit cell growth, decrease soft agar colony formation activity and induce apoptosis in RKO and SW620 cells. Correlation analysis between the expression of IGFBP7 in CRC tissue and the prognosis in 218 patients showed that high expression of IGFBP7 was associated with favourable prognosis. Based on above results, we conclude that IGFBP7 plays a potential tumor suppressor role in colorectal carcinogenesis. |
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| AbstractList | Insulin-like growth factor binding protein-7 (IGFBP7) is a gene identified as being low expressed in colorectal adenocarcinoma (CRC) cell lines. In the current study, we investigated the function of IGFBP7 in CRC by transfection studies. We found that IGFBP7 could inhibit cell growth, decrease soft agar colony formation activity and induce apoptosis in RKO and SW620 cells. Correlation analysis between the expression of IGFBP7 in CRC tissue and the prognosis in 218 patients showed that high expression of IGFBP7 was associated with favourable prognosis. Based on above results, we conclude that IGFBP7 plays a potential tumor suppressor role in colorectal carcinogenesis. Insulin-like growth factor binding protein-7 (IGFBP7) is a gene identified as being low expressed in colorectal adenocarcinoma (CRC) cell lines. In the current study, we investigated the function of IGFBP7 in CRC by transfection studies. We found that IGFBP7 could inhibit cell growth, decrease soft agar colony formation activity and induce apoptosis in RKO and SW620 cells. Correlation analysis between the expression of IGFBP7 in CRC tissue and the prognosis in 218 patients showed that high expression of IGFBP7 was associated with favorable prognosis. Based on above results, we conclude that IGFBP7 plays a potential tumor suppressor role in colorectal carcinogenesis. |
| Author | Xu, Fangying Lv, Bingjian Di, Meijuan Ruan, Wenjing Huang, Qiong Hu, Hu Xu, Enping Deng, Hong Ma, Yu Dong, Jiankang Lin, Jie Lai, Maode Cui, Jing |
| Author_xml | – sequence: 1 givenname: Wenjing surname: Ruan fullname: Ruan, Wenjing – sequence: 2 givenname: Enping surname: Xu fullname: Xu, Enping – sequence: 3 givenname: Fangying surname: Xu fullname: Xu, Fangying – sequence: 4 givenname: Yu surname: Ma fullname: Ma, Yu – sequence: 5 givenname: Hong surname: Deng fullname: Deng, Hong – sequence: 6 givenname: Qiong surname: Huang fullname: Huang, Qiong – sequence: 7 givenname: Bingjian surname: Lv fullname: Lv, Bingjian – sequence: 8 givenname: Hu surname: Hu fullname: Hu, Hu – sequence: 9 givenname: Jie surname: Lin fullname: Lin, Jie – sequence: 10 givenname: Jing surname: Cui fullname: Cui, Jing – sequence: 11 givenname: Meijuan surname: Di fullname: Di, Meijuan – sequence: 12 givenname: Jiankang surname: Dong fullname: Dong, Jiankang – sequence: 13 givenname: Maode surname: Lai fullname: Lai, Maode |
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| Snippet | Insulin-like growth factor binding protein-7 (IGFBP7) is a gene identified as being low expressed in colorectal adenocarcinoma (CRC) cell lines. In the current... |
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| SubjectTerms | Adenocarcinoma - chemistry Adenocarcinoma - genetics Adenocarcinoma - mortality Aged Binding Biology Bioscience Calcium Cancer Cell Cell Line, Tumor Cell Proliferation Cell Transformation, Neoplastic - genetics Colorectal Neoplasms - chemistry Colorectal Neoplasms - genetics Colorectal Neoplasms - mortality Cycle Female Humans Insulin-Like Growth Factor Binding Proteins - analysis Insulin-Like Growth Factor Binding Proteins - genetics Insulin-Like Growth Factor Binding Proteins - physiology Landes Male Middle Aged Organogenesis Prognosis Proteins Survival Transfection Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - physiology Up-Regulation |
| Title | IGFBP7 plays a potential tumor suppressor role in colorectal carcinogenesis |
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