Propriospinal Bypass of the Serotonergic System That Can Facilitate Stepping

• Published in: The Journal of neuroscience Vol. 29; no. 17; pp. 5681 - 5689
• Main Authors: Gerasimenko, Yury, Musienko, Pavel, Bogacheva, Irina, Moshonkina, Tatiana, Savochin, Alexandr, Lavrov, Igor, Roy, Roland R, Edgerton, V. Reggie
• Format: Journal Article
• Language: English
• Published: United States Soc Neuroscience 29.04.2009; Society for Neuroscience
• Subjects: Animals; Cats; Decerebrate State - physiopathology; Hindlimb - innervation; Hindlimb - physiology; Lumbar Vertebrae; Motor Activity - physiology; Neural Pathways - physiology; Proprioception - physiology; Receptors, Serotonin - physiology; Serotonin - physiology; Spinal Cord - physiology; Walking - physiology; Weight-Bearing - physiology

The neurotransmitter systems mediating spinal locomotion in response to epidural spinal cord stimulation (ES) have not been identified. Here, we examine the role of the serotonergic system in regulating locomotor behavior of decerebrated cats during ES at L4-L5. ES elicited coordinated, weight-beari...