Rapid toxin sequestration modifies poison frog physiology
Poison frogs sequester chemical defenses from their diet of leaf litter arthropods for defense against predation. Little is known about the physiological adaptations that confer this unusual bioaccumulation ability. We conducted an alkaloid-feeding experiment with the Diablito poison frog ( ) to det...
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| Published in | Journal of experimental biology Vol. 224; no. Pt 3 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
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01.02.2021
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| Abstract | Poison frogs sequester chemical defenses from their diet of leaf litter arthropods for defense against predation. Little is known about the physiological adaptations that confer this unusual bioaccumulation ability. We conducted an alkaloid-feeding experiment with the Diablito poison frog (
) to determine how quickly alkaloids are accumulated and how toxins modify frog physiology using quantitative proteomics. Diablito frogs rapidly accumulated the alkaloid decahydroquinoline within 4 days, and dietary alkaloid exposure altered protein abundance in the intestines, liver and skin. Many proteins that increased in abundance with decahydroquinoline accumulation are plasma glycoproteins, including the complement system and the toxin-binding protein saxiphilin. Other protein classes that change in abundance with decahydroquinoline accumulation are membrane proteins involved in small molecule transport and metabolism. Overall, this work shows that poison frogs can rapidly accumulate alkaloids, which alter carrier protein abundance, initiate an immune response, and alter small molecule transport and metabolism dynamics across tissues. |
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| AbstractList | Poison frogs sequester chemical defenses from their diet of leaf litter arthropods for defense against predation. Little is known about the physiological adaptations that confer this unusual bioaccumulation ability. We conducted an alkaloid-feeding experiment with the Diablito poison frog (
) to determine how quickly alkaloids are accumulated and how toxins modify frog physiology using quantitative proteomics. Diablito frogs rapidly accumulated the alkaloid decahydroquinoline within 4 days, and dietary alkaloid exposure altered protein abundance in the intestines, liver and skin. Many proteins that increased in abundance with decahydroquinoline accumulation are plasma glycoproteins, including the complement system and the toxin-binding protein saxiphilin. Other protein classes that change in abundance with decahydroquinoline accumulation are membrane proteins involved in small molecule transport and metabolism. Overall, this work shows that poison frogs can rapidly accumulate alkaloids, which alter carrier protein abundance, initiate an immune response, and alter small molecule transport and metabolism dynamics across tissues. Poison frogs sequester chemical defenses from their diet of leaf litter arthropods for defense against predation. Little is known about the physiological adaptations that confer this unusual bioaccumulation ability. We conducted an alkaloid-feeding experiment with the Diablito poison frog ( Oophaga sylvatica ) to determine how quickly alkaloids are accumulated and how toxins modify frog physiology using quantitative proteomics. Diablito frogs rapidly accumulated the alkaloid decahydroquinoline within 4 days, and dietary alkaloid exposure altered protein abundance in the intestines, liver and skin. Many proteins that increased in abundance with decahydroquinoline accumulation are plasma glycoproteins, including the complement system and the toxin-binding protein saxiphilin. Other protein classes that change in abundance with decahydroquinoline accumulation are membrane proteins involved in small molecule transport and metabolism. Overall, this work shows that poison frogs can rapidly accumulate alkaloids, which alter carrier protein abundance, initiate an immune response, and alter small molecule transport and metabolism dynamics across tissues. Summary: Poison frogs rapidly accumulate toxins, which changes the abundance of proteins involved in the immune system and small molecule binding and metabolism across tissues. ABSTRACT Poison frogs sequester chemical defenses from their diet of leaf litter arthropods for defense against predation. Little is known about the physiological adaptations that confer this unusual bioaccumulation ability. We conducted an alkaloid-feeding experiment with the Diablito poison frog (Oophaga sylvatica) to determine how quickly alkaloids are accumulated and how toxins modify frog physiology using quantitative proteomics. Diablito frogs rapidly accumulated the alkaloid decahydroquinoline within 4 days, and dietary alkaloid exposure altered protein abundance in the intestines, liver and skin. Many proteins that increased in abundance with decahydroquinoline accumulation are plasma glycoproteins, including the complement system and the toxin-binding protein saxiphilin. Other protein classes that change in abundance with decahydroquinoline accumulation are membrane proteins involved in small molecule transport and metabolism. Overall, this work shows that poison frogs can rapidly accumulate alkaloids, which alter carrier protein abundance, initiate an immune response, and alter small molecule transport and metabolism dynamics across tissues. |
| Author | Gygi, Steven P O'Connell, Jeremy D O'Connell, Lauren A Paulo, Joao A Trauger, Sunia A Murray, Andrew W |
| AuthorAffiliation | 4 Harvard Center for Mass Spectrometry, Harvard University , Cambridge, MA 02138 , USA 3 Department of Cell Biology, Harvard Medical School, Boston, MA 02115 , USA 1 Department of Biology , Stanford University , Stanford, CA 94305 , USA 2 Department of Molecular and Cellular Biology , Harvard University , Cambridge, MA 02138 , USA 5 Department of Molecular and Cellular Biology , Harvard University , Cambridge, MA 02138 , USA |
| AuthorAffiliation_xml | – name: 3 Department of Cell Biology, Harvard Medical School, Boston, MA 02115 , USA – name: 1 Department of Biology , Stanford University , Stanford, CA 94305 , USA – name: 4 Harvard Center for Mass Spectrometry, Harvard University , Cambridge, MA 02138 , USA – name: 5 Department of Molecular and Cellular Biology , Harvard University , Cambridge, MA 02138 , USA – name: 2 Department of Molecular and Cellular Biology , Harvard University , Cambridge, MA 02138 , USA |
| Author_xml | – sequence: 1 givenname: Lauren A orcidid: 0000-0002-2706-4077 surname: O'Connell fullname: O'Connell, Lauren A email: loconnel@stanford.edu organization: Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA – sequence: 2 givenname: Jeremy D surname: O'Connell fullname: O'Connell, Jeremy D organization: Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA – sequence: 3 givenname: Joao A surname: Paulo fullname: Paulo, Joao A organization: Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA – sequence: 4 givenname: Sunia A surname: Trauger fullname: Trauger, Sunia A organization: Harvard Center for Mass Spectrometry, Harvard University, Cambridge, MA 02138, USA – sequence: 5 givenname: Steven P surname: Gygi fullname: Gygi, Steven P organization: Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA – sequence: 6 givenname: Andrew W orcidid: 0000-0002-0868-6604 surname: Murray fullname: Murray, Andrew W organization: Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA |
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| Keywords | Alkaloids Cytochrome P450s Complement system Saxiphilin Proteomics |
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| Snippet | Poison frogs sequester chemical defenses from their diet of leaf litter arthropods for defense against predation. Little is known about the physiological... ABSTRACT Poison frogs sequester chemical defenses from their diet of leaf litter arthropods for defense against predation. Little is known about the... |
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| SubjectTerms | Animals Anura Arthropods Poisons Predatory Behavior Short Communication Toxins, Biological - toxicity |
| Title | Rapid toxin sequestration modifies poison frog physiology |
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