Uric acid and chronic kidney disease: which is chasing which?

• Published in: Nephrology, dialysis, transplantation Vol. 28; no. 9; pp. 2221 - 2228
• Main Authors: Johnson, R. J., Nakagawa, T., Jalal, D., Sanchez-Lozada, L. G., Kang, D.-H., Ritz, E.
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.09.2013
• Subjects: Animals; Cutting-Edge Renal Science; Humans; Rats; Renal Insufficiency, Chronic - etiology; Risk Factors; Uric Acid - metabolism; hyperuricemia; chronic kidney disease; allopurinol; uric acid; gout
• ISSN: 0931-0509; 1460-2385; 1460-2385
• DOI: 10.1093/ndt/gft029

Serum uric acid is commonly elevated in subjects with chronic kidney disease (CKD), but was historically viewed as an issue of limited interest. Recently, uric acid has been resurrected as a potential contributory risk factor in the development and progression of CKD. Most studies documented that an...