Rho GAP myosin IXa is a regulator of kidney tubule function

• Published in: American journal of physiology. Renal physiology Vol. 309; no. 6; pp. F501 - F513
• Main Authors: Thelen, Sabine, Abouhamed, Marouan, Ciarimboli, Giuliano, Edemir, Bayram, Bähler, Martin
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 15.09.2015
• Subjects: Albumins - metabolism; Animals; Carrier Proteins - metabolism; Cells; Cells, Cultured; Endocytosis - physiology; GTPase-Activating Proteins - genetics; GTPase-Activating Proteins - physiology; Hydronephrosis - genetics; Hydronephrosis - metabolism; Kidney diseases; Kidney Tubules - anatomy & histology; Kidney Tubules - cytology; Kidney Tubules - physiology; LLC-PK1 Cells; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular weight; Myosins - genetics; Myosins - physiology; Nephrons - physiology; Polyuria - genetics; Polyuria - metabolism; Proteins; rho-Associated Kinases - metabolism; Rodents; Swine; Vasopressins - metabolism; proximal tubule; proteinuria; Rho signaling; Rho GTPase-activating protein; myosin 9a

Mammalian class IX myosin Myo9a is a single-headed, actin-dependent motor protein with Rho GTPase-activating protein activity that negatively regulates Rho GTPase signaling. Myo9a is abundantly expressed in ciliated epithelial cells of several organs. In mice, genetic deletion of Myo9a leads to the...