Resistin is expressed in human macrophages and directly regulated by PPARγ activators

• Published in: Biochemical and biophysical research communications Vol. 300; no. 2; pp. 472 - 476
• Main Authors: Patel, Lisa, Buckels, Amy C, Kinghorn, Ian J, Murdock, Paul R, Holbrook, Joanna D, Plumpton, Christopher, Macphee, Colin H, Smith, Stephen A
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 10.01.2003
• Subjects: Base Sequence; Cell Differentiation; Cells, Cultured; Gene Expression Regulation; Hormones, Ectopic - biosynthesis; Hormones, Ectopic - genetics; Humans; Intercellular Signaling Peptides and Proteins; Macrophage; Macrophages - metabolism; Monocyte; Monocytes - physiology; Polymerase Chain Reaction; PPARγ; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear - agonists; Receptors, Cytoplasmic and Nuclear - metabolism; Resistin; Response Elements; RNA, Messenger - biosynthesis; Rosiglitazone; Thiazoles - pharmacology; Thiazolidinediones; Tissue Distribution; Transcription Factors - agonists; Transcription Factors - metabolism; Up-Regulation; Rosiglitazone; Monocyte; PPARγ; Macrophage; Resistin

Resistin is a cysteine-rich protein postulated to be a molecular link between obesity and type 2 diabetes. The aim of this study was to investigate the role of PPARγ in the regulation of resistin expression in human primary macrophages. Fluorescent real-time PCR (Taqman) analysis of resistin express...