MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis

• Published in: Nucleic acids research Vol. 45; no. 11; pp. 6388 - 6403
• Main Authors: Lai, Binbin, Lee, Ji-Eun, Jang, Younghoon, Wang, Lifeng, Peng, Weiqun, Ge, Kai
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 20.06.2017
• Subjects: Adipocytes, Brown - physiology; Adipogenesis; Adipose Tissue, Brown - cytology; Animals; Cells, Cultured; CREB-Binding Protein - metabolism; E1A-Associated p300 Protein - metabolism; Enhancer Elements, Genetic; Gene regulation, Chromatin and Epigenetics; Histone-Lysine N-Methyltransferase - physiology; Mice, Transgenic; Protein Binding; Transcriptional Activation; Transcriptome

Histone H3K4me1/2 methyltransferases MLL3/MLL4 and H3K27 acetyltransferases CBP/p300 are major enhancer epigenomic writers. To understand how these epigenomic writers orchestrate enhancer landscapes in cell differentiation, we have profiled genomic binding of MLL4, CBP, lineage-determining transcrip...