Arabidopsis MRG domain proteins bridge two histone modifications to elevate expression of flowering genes

Trimethylation of lysine 36 of histone H3 (H3K36me3) is found to be associated with various transcription events. In Arabidopsis, the H3K36me3 level peaks in the first half of coding regions, which is in contrast to the 3'-end enrichment in animals. The MRG15 family proteins function as 'r...

Full description

Saved in:
Bibliographic Details
Published inNucleic acids research Vol. 42; no. 17; pp. 10960 - 10974
Main Authors Xu, Yifeng, Gan, Eng-Seng, Zhou, Jie, Wee, Wan-Yi, Zhang, Xiaoyu, Ito, Toshiro
Format Journal Article
LanguageEnglish
Published England Oxford University Press 29.09.2014
Subjects
Online AccessGet full text

Cover

Loading…
Abstract Trimethylation of lysine 36 of histone H3 (H3K36me3) is found to be associated with various transcription events. In Arabidopsis, the H3K36me3 level peaks in the first half of coding regions, which is in contrast to the 3'-end enrichment in animals. The MRG15 family proteins function as 'reader' proteins by binding to H3K36me3 to control alternative splicing or prevent spurious intragenic transcription in animals. Here, we demonstrate that two closely related Arabidopsis homologues (MRG1 and MRG2) are localised to the euchromatin and redundantly ensure the increased transcriptional levels of two flowering time genes with opposing functions, FLOWERING LOCUS C and FLOWERING LOCUS T (FT). MRG2 directly binds to the FT locus and elevates the expression in an H3K36me3-dependent manner. MRG1/2 binds to H3K36me3 with their chromodomain and interact with the histone H4-specific acetyltransferases (HAM1 and HAM2) to achieve a high expression level through active histone acetylation at the promoter and 5' regions of target loci. Together, this study presents a mechanistic link between H3K36me3 and histone H4 acetylation. Our data also indicate that the biological functions of MRG1/2 have diversified from their animal homologues during evolution, yet they still maintain their conserved H3K36me3-binding molecular function.
AbstractList Trimethylation of lysine 36 of histone H3 (H3K36me3) is found to be associated with various transcription events. In Arabidopsis, the H3K36me3 level peaks in the first half of coding regions, which is in contrast to the 3'-end enrichment in animals. The MRG15 family proteins function as 'reader' proteins by binding to H3K36me3 to control alternative splicing or prevent spurious intragenic transcription in animals. Here, we demonstrate that two closely related Arabidopsis homologues (MRG1 and MRG2) are localised to the euchromatin and redundantly ensure the increased transcriptional levels of two flowering time genes with opposing functions, FLOWERING LOCUS C and FLOWERING LOCUS T (FT). MRG2 directly binds to the FT locus and elevates the expression in an H3K36me3-dependent manner. MRG1/2 binds to H3K36me3 with their chromodomain and interact with the histone H4-specific acetyltransferases (HAM1 and HAM2) to achieve a high expression level through active histone acetylation at the promoter and 5' regions of target loci. Together, this study presents a mechanistic link between H3K36me3 and histone H4 acetylation. Our data also indicate that the biological functions of MRG1/2 have diversified from their animal homologues during evolution, yet they still maintain their conserved H3K36me3-binding molecular function.
Trimethylation of lysine 36 of histone H3 (H3K36me3) is found to be associated with various transcription events. In Arabidopsis , the H3K36me3 level peaks in the first half of coding regions, which is in contrast to the 3′-end enrichment in animals. The MRG15 family proteins function as ‘reader’ proteins by binding to H3K36me3 to control alternative splicing or prevent spurious intragenic transcription in animals. Here, we demonstrate that two closely related Arabidopsis homologues (MRG1 and MRG2) are localised to the euchromatin and redundantly ensure the increased transcriptional levels of two flowering time genes with opposing functions, FLOWERING LOCUS C and FLOWERING LOCUS T (FT) . MRG2 directly binds to the FT locus and elevates the expression in an H3K36me3-dependent manner. MRG1/2 binds to H3K36me3 with their chromodomain and interact with the histone H4-specific acetyltransferases (HAM1 and HAM2) to achieve a high expression level through active histone acetylation at the promoter and 5′ regions of target loci. Together, this study presents a mechanistic link between H3K36me3 and histone H4 acetylation. Our data also indicate that the biological functions of MRG1/2 have diversified from their animal homologues during evolution, yet they still maintain their conserved H3K36me3-binding molecular function.
Author Wee, Wan-Yi
Zhou, Jie
Gan, Eng-Seng
Ito, Toshiro
Xu, Yifeng
Zhang, Xiaoyu
Author_xml – sequence: 1
  givenname: Yifeng
  surname: Xu
  fullname: Xu, Yifeng
  organization: Temasek Life Sciences Laboratory, National University of Singapore, Singapore 117604, Republic of Singapore
– sequence: 2
  givenname: Eng-Seng
  surname: Gan
  fullname: Gan, Eng-Seng
  organization: Temasek Life Sciences Laboratory, National University of Singapore, Singapore 117604, Republic of Singapore Department of Biological Sciences, National University of Singapore, Singapore 117543, Republic of Singapore
– sequence: 3
  givenname: Jie
  surname: Zhou
  fullname: Zhou, Jie
  organization: Temasek Life Sciences Laboratory, National University of Singapore, Singapore 117604, Republic of Singapore
– sequence: 4
  givenname: Wan-Yi
  surname: Wee
  fullname: Wee, Wan-Yi
  organization: Temasek Life Sciences Laboratory, National University of Singapore, Singapore 117604, Republic of Singapore
– sequence: 5
  givenname: Xiaoyu
  surname: Zhang
  fullname: Zhang, Xiaoyu
  organization: Department of Plant Biology, University of Georgia, Athens, GA 30602-7271, USA
– sequence: 6
  givenname: Toshiro
  surname: Ito
  fullname: Ito, Toshiro
  email: itot@tll.org.sg
  organization: Temasek Life Sciences Laboratory, National University of Singapore, Singapore 117604, Republic of Singapore Department of Biological Sciences, National University of Singapore, Singapore 117543, Republic of Singapore itot@tll.org.sg
BackLink https://www.ncbi.nlm.nih.gov/pubmed/25183522$$D View this record in MEDLINE/PubMed
BookMark eNpVkVtLHTEUhYMoes7Rl_6AksciTM19Zl4KIl4KFqG0zyEz2TNGZ5JpkqP135tyrLRPG_b-WGsv1hrt--ABoQ-UfKak5WfexLPxcVs3dA-tKFesEq1i-2hFOJEVJaI5QuuUHgihgkpxiI6YpA2XjK2QO4-mczYsySX87fs1tmE2zuMlhgzOJ9xFZ0fA-Tnge5dyccZzsG5wvckuFCAHDBM8mQwYfi8RUiprHAY8TOEZovMjHsFDOkYHg5kSnLzNDfp5dfnj4qa6vbv-enF-W_VCiFyVFJ3hoibKtrztOjAt46zpGj5IVbJAbaVgTSttLZUSfV2D4lDL3nSst5TzDfqy01223Qy2B5-jmfQS3Wziiw7G6f8v3t3rMTxpQWtFlSoCn94EYvi1hZT17FIP02Q8hG3StPhSyngjCnq6Q_sYUoowvNtQov90o0s3etdNgT_--9g7-rcM_gqU4o-H
CitedBy_id crossref_primary_10_1186_s13059_015_0770_6
crossref_primary_10_1007_s42994_022_00070_9
crossref_primary_10_1007_s00018_021_03794_x
crossref_primary_10_1186_s12870_015_0461_1
crossref_primary_10_3389_fpls_2020_00125
crossref_primary_10_1016_j_xplc_2023_100552
crossref_primary_10_15252_embj_201797499
crossref_primary_10_1007_s13238_016_0310_5
crossref_primary_10_1111_nph_16616
crossref_primary_10_1111_tpj_14780
crossref_primary_10_9787_PBB_2019_7_3_161
crossref_primary_10_1016_j_pbi_2024_102598
crossref_primary_10_1074_mcp_RA118_000957
crossref_primary_10_1016_j_jgg_2019_09_005
crossref_primary_10_1016_j_jgg_2023_02_011
crossref_primary_10_1016_j_repbre_2022_11_003
crossref_primary_10_1016_j_celrep_2024_113726
crossref_primary_10_1111_pbi_12584
crossref_primary_10_1016_j_tplants_2020_03_005
crossref_primary_10_1016_j_pbi_2021_102008
crossref_primary_10_1073_pnas_1604666113
crossref_primary_10_1002_csc2_21037
crossref_primary_10_1016_j_plaphy_2024_108841
crossref_primary_10_1016_j_xplc_2019_100008
crossref_primary_10_3389_fpls_2014_00803
crossref_primary_10_1038_s41467_021_27882_5
crossref_primary_10_1186_s13059_017_1235_x
crossref_primary_10_3390_ijms24119219
crossref_primary_10_1093_plphys_kiab275
crossref_primary_10_3390_ijms19103196
crossref_primary_10_3389_fgene_2020_00998
crossref_primary_10_1093_jxb_erae054
crossref_primary_10_1111_pce_13557
crossref_primary_10_3389_freae_2024_1404958
crossref_primary_10_1111_pbr_13148
crossref_primary_10_1016_j_pbi_2016_08_002
crossref_primary_10_1093_plphys_kiaa103
crossref_primary_10_1002_tpg2_20320
crossref_primary_10_1093_fqsafe_fyad052
crossref_primary_10_1074_jbc_M117_788224
crossref_primary_10_1016_j_plantsci_2023_111926
crossref_primary_10_1104_pp_114_255737
crossref_primary_10_1007_s00299_023_03042_5
crossref_primary_10_1051_jbio_2017004
crossref_primary_10_1186_s12870_022_04031_8
crossref_primary_10_1016_j_mcpro_2024_100795
crossref_primary_10_1186_s13059_015_0640_2
crossref_primary_10_1111_tpj_12873
crossref_primary_10_1186_s13073_018_0538_1
crossref_primary_10_3389_fpls_2021_782450
crossref_primary_10_1042_BCJ20160123
crossref_primary_10_3390_ijms23010466
crossref_primary_10_1111_ppl_13101
Cites_doi 10.1016/j.devcel.2011.09.019
10.1074/jbc.M008159200
10.1093/oxfordjournals.molbev.a026407
10.1101/gad.1110503
10.1038/nprot.2006.286
10.1074/jbc.M806564200
10.1016/S1360-1385(00)01839-2
10.1038/sj.emboj.7601926
10.1016/j.cell.2009.06.049
10.1038/nature06561
10.1126/science.1139004
10.1128/MCB.01607-07
10.1038/nsmb.1644
10.1111/j.1365-313X.2007.03264.x
10.1016/j.cub.2013.01.030
10.1371/journal.pgen.1000077
10.1038/emboj.2011.103
10.1016/j.devcel.2011.12.016
10.1038/nsmb.2435
10.1016/j.tplants.2012.05.001
10.1016/S1097-2765(00)00128-3
10.1371/journal.pbio.1001649
10.1038/nature722
10.1093/nar/gkl989
10.1038/35044127
10.1016/S0378-1119(01)00372-9
10.1371/journal.ppat.1001137
10.1093/emboj/18.18.5108
10.1016/j.jplph.2012.11.007
10.1371/journal.pone.0007817
10.1038/35074138
10.1105/tpc.108.063131
10.1016/j.str.2008.08.008
10.1101/gad.1056603
10.1186/1746-4811-4-24
10.1038/nsmb.1797
10.1016/j.molcel.2011.03.025
10.1038/nature05915
10.1016/S0168-9525(03)00115-X
10.1128/MCB.25.14.5947-5954.2005
10.1074/jbc.M110.194027
10.1093/emboj/cdg248
10.1074/jbc.M203839200
10.1371/journal.pone.0003404
10.1016/j.molcel.2005.11.021
10.1128/MCB.22.5.1298-1306.2002
10.1126/science.286.5446.1960
10.1101/gad.269603
10.1186/1471-2229-8-121
10.1093/mp/ssp092
10.1126/science.1184208
10.1016/j.cell.2005.10.023
10.1128/MCB.20.1.312-318.2000
10.1016/j.gene.2008.06.022
10.1038/ncb1329
10.1016/j.cell.2005.10.025
10.1038/ng.322
10.1074/jbc.M103435200
10.1101/gad.1800409
10.1128/MCB.00006-08
10.1128/MCB.24.2.757-764.2004
10.1104/pp.105.063743
10.1126/science.1069473
ContentType Journal Article
Copyright The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.
The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research. 2014
Copyright_xml – notice: The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.
– notice: The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research. 2014
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7X8
5PM
DOI 10.1093/nar/gku781
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
MEDLINE - Academic
DatabaseTitleList MEDLINE

Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Anatomy & Physiology
Chemistry
EISSN 1362-4962
EndPage 10974
ExternalDocumentID 10_1093_nar_gku781
25183522
Genre Research Support, Non-U.S. Gov't
Journal Article
GroupedDBID ---
-DZ
-~X
.55
.GJ
.I3
0R~
123
18M
1TH
29N
2WC
3O-
4.4
482
53G
5VS
5WA
6.Y
70E
85S
A8Z
AAFWJ
AAHBH
AAMVS
AAOGV
AAPPN
AAPXW
AAUQX
AAVAP
AAWDT
AAYJJ
ABPTD
ABQLI
ABQTQ
ABSAR
ABSMQ
ABXVV
ACFRR
ACGFO
ACGFS
ACIPB
ACIWK
ACMRT
ACNCT
ACPQN
ACPRK
ACUTJ
ACZBC
ADBBV
ADHZD
AEGXH
AEHUL
AEKPW
AENEX
AENZO
AFFNX
AFRAH
AFSHK
AFULF
AFYAG
AGKRT
AGMDO
AHMBA
AIAGR
ALMA_UNASSIGNED_HOLDINGS
ALUQC
ANFBD
AOIJS
AQDSO
ASAOO
ASPBG
ATDFG
ATTQO
AVWKF
AZFZN
BAWUL
BAYMD
BCNDV
BEYMZ
BTTYL
C1A
CAG
CGR
CIDKT
COF
CS3
CUY
CVF
CXTWN
CZ4
D0S
DFGAJ
DIK
DU5
D~K
E3Z
EBD
EBS
ECM
EIF
EJD
ELUNK
EMOBN
ESTFP
F20
F5P
FEDTE
GROUPED_DOAJ
GX1
H13
HH5
HVGLF
HYE
HZ~
H~9
IH2
KAQDR
KQ8
KSI
M49
MBTAY
MVM
M~E
NPM
NTWIH
NU-
OAWHX
OBC
OBS
OEB
OES
OJQWA
OVD
O~Y
P2P
PB-
PEELM
PQQKQ
QBD
R44
RD5
RNI
RNS
ROL
ROX
ROZ
RPM
RXO
RZF
RZO
SJN
SV3
TCN
TEORI
TN5
TOX
TR2
UHB
WG7
WOQ
X7H
X7M
XSB
XSW
YSK
ZKX
ZXP
~91
~D7
~KM
AAYXX
ABEJV
CITATION
7X8
5PM
AFPKN
ID FETCH-LOGICAL-c444t-781ba34706d939bbea92328b83f56104e7d542895d75664c77e63e75cab2cd133
IEDL.DBID RPM
ISSN 0305-1048
IngestDate Tue Sep 17 21:27:00 EDT 2024
Wed Dec 04 03:38:29 EST 2024
Fri Dec 06 04:48:38 EST 2024
Tue Oct 15 23:51:20 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 17
Language English
License The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.
http://creativecommons.org/licenses/by-nc/4.0
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c444t-781ba34706d939bbea92328b83f56104e7d542895d75664c77e63e75cab2cd133
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176166/
PMID 25183522
PQID 1566112384
PQPubID 23479
PageCount 15
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_4176166
proquest_miscellaneous_1566112384
crossref_primary_10_1093_nar_gku781
pubmed_primary_25183522
PublicationCentury 2000
PublicationDate 2014-09-29
PublicationDateYYYYMMDD 2014-09-29
PublicationDate_xml – month: 09
  year: 2014
  text: 2014-09-29
  day: 29
PublicationDecade 2010
PublicationPlace England
PublicationPlace_xml – name: England
PublicationTitle Nucleic acids research
PublicationTitleAlternate Nucleic Acids Res
PublicationYear 2014
Publisher Oxford University Press
Publisher_xml – name: Oxford University Press
References 19174535 - Plant Cell. 2009 Jan;21(1):39-53
11290425 - Gene. 2001 Mar 21;266(1-2):111-21
23394836 - Curr Biol. 2013 Feb 18;23(4):345-50
17877703 - Plant J. 2007 Nov;52(4):615-26
18638531 - Gene. 2008 Oct 15;423(1):43-7
19698979 - Cell. 2009 Sep 4;138(5):1019-31
23142980 - Nat Struct Mol Biol. 2012 Dec;19(12):1266-72
20949080 - PLoS Pathog. 2010;6(10):e1001137
16166256 - Plant Physiol. 2005 Sep;139(1):5-17
18818090 - Structure. 2008 Nov 12;16(11):1740-50
18007591 - EMBO J. 2007 Dec 12;26(24):4974-84
14701747 - Mol Cell Biol. 2004 Jan;24(2):757-64
16299497 - Nat Cell Biol. 2005 Dec;7(12):1256-60
11500496 - J Biol Chem. 2001 Oct 19;276(42):39171-8
18070919 - Mol Cell Biol. 2008 Feb;28(4):1348-60
19915673 - PLoS One. 2009;4(11):e7817
12897052 - Genes Dev. 2003 Aug 1;17(15):1823-8
17487191 - Nat Protoc. 2006;1(4):2019-25
11100734 - Nature. 2000 Nov 23;408(6811):495-8
19040736 - BMC Plant Biol. 2008;8:121
22658650 - Trends Plant Sci. 2012 Sep;17(9):556-62
12897054 - Genes Dev. 2003 Aug 1;17(15):1870-81
18922163 - Plant Methods. 2008 Oct 15;4:24
21487388 - EMBO J. 2011 May 18;30(10):1928-38
10594033 - Mol Cell Biol. 2000 Jan;20(1):312-8
16286007 - Cell. 2005 Nov 18;123(4):581-92
11323677 - Nature. 2001 Apr 26;410(6832):1116-20
21239496 - J Biol Chem. 2011 Mar 11;286(10):7983-9
19648925 - Nat Struct Mol Biol. 2009 Aug;16(8):825-32
18852898 - PLoS One. 2008;3(10):e3404
11882902 - Nature. 2002 Mar 7;416(6876):103-7
16364921 - Mol Cell. 2005 Dec 22;20(6):971-8
19952001 - Mol Plant. 2010 Jan;3(1):174-91
21549310 - Mol Cell. 2011 May 6;42(3):330-41
17135209 - Nucleic Acids Res. 2006;34(22):6621-8
24019760 - PLoS Biol. 2013 Sep;11(9):e1001649
18216783 - Nature. 2008 Feb 7;451(7179):734-7
11163204 - Mol Cell. 2000 Dec;6(6):1297-307
15988010 - Mol Cell Biol. 2005 Jul;25(14):5947-54
18984594 - J Biol Chem. 2008 Dec 26;283(52):36504-12
12782659 - Genes Dev. 2003 Jun 1;17(11):1415-28
17510366 - Science. 2007 May 18;316(5827):1050-4
23921974 - Curr Top Microbiol Immunol. 2014;377:111-26
17522673 - Nature. 2007 May 24;447(7143):407-12
20400950 - Nat Struct Mol Biol. 2010 May;17(5):617-9
22421046 - Dev Cell. 2012 Mar 13;22(3):610-24
10583960 - Science. 1999 Dec 3;286(5446):1960-2
12801725 - Trends Genet. 2003 Jun;19(6):321-9
23273925 - J Plant Physiol. 2013 Mar 1;170(4):444-51
12773392 - EMBO J. 2003 Jun 2;22(11):2776-87
16739577 - Methods Mol Biol. 2006;323:173-86
19182803 - Nat Genet. 2009 Mar;41(3):376-81
12397079 - J Biol Chem. 2002 Dec 27;277(52):50860-6
18347056 - Mol Cell Biol. 2008 May;28(10):3401-9
10908644 - Mol Biol Evol. 2000 Aug;17(8):1240-50
22172672 - Dev Cell. 2011 Dec 13;21(6):1092-103
20133523 - Science. 2010 Feb 19;327(5968):996-1000
10487762 - EMBO J. 1999 Sep 15;18(18):5108-19
11036083 - J Biol Chem. 2001 Feb 2;276(5):3484-91
16286008 - Cell. 2005 Nov 18;123(4):593-605
18725930 - PLoS Genet. 2008;4(8):e1000077
19651987 - Genes Dev. 2009 Aug 1;23(15):1791-804
11173289 - Trends Plant Sci. 2001 Feb;6(2):59-65
11839797 - Mol Cell Biol. 2002 Mar;22(5):1298-306
11859155 - Science. 2002 Mar 15;295(5562):2080-3
Carrozza ( key 20171012092311_B2) 2005; 123
Vezzoli ( key 20171012092311_B49) 2010; 17
Marin ( key 20171012092311_B7) 2000; 17
Pardo ( key 20171012092311_B18) 2002; 277
He ( key 20171012092311_B35) 2012; 17
Smith ( key 20171012092311_B30) 2000; 20
Xiao ( key 20171012092311_B34) 2013; 170
Czechowski ( key 20171012092311_B39) 2005; 139
Jacobs ( key 20171012092311_B10) 2002; 295
Cazzonelli ( key 20171012092311_B58) 2010; 3
Xu ( key 20171012092311_B15) 2008; 16
Zhang ( key 20171012092311_B16) 2006; 34
Latrasse ( key 20171012092311_B32) 2008; 8
Nielsen ( key 20171012092311_B11) 2002; 416
Grini ( key 20171012092311_B38) 2009; 4
Suarez-Lopez ( key 20171012092311_B55) 2001; 410
Eisen ( key 20171012092311_B20) 2001; 276
Oh ( key 20171012092311_B57) 2008; 4
Lysak ( key 20171012092311_B44) 2006; 323
Bell ( key 20171012092311_B65) 2008; 28
Xu ( key 20171012092311_B41) 2013; 23
Sparkes ( key 20171012092311_B43) 2006; 1
Earley ( key 20171012092311_B33) 2007; 52
Schmitges ( key 20171012092311_B51) 2011; 42
Carrozza ( key 20171012092311_B29) 2003; 19
Palma ( key 20171012092311_B54) 2010; 6
Vogelauer ( key 20171012092311_B25) 2000; 408
Fischle ( key 20171012092311_B13) 2003; 17
Leung ( key 20171012092311_B17) 2001; 276
Wang ( key 20171012092311_B63) 2009; 138
Berger ( key 20171012092311_B9) 2007; 447
Musselman ( key 20171012092311_B48) 2012; 19
Chen ( key 20171012092311_B23) 2008; 451
Kolasinska-Zwierz ( key 20171012092311_B1) 2009; 41
Keogh ( key 20171012092311_B4) 2005; 123
Boudreault ( key 20171012092311_B26) 2003; 17
Min ( key 20171012092311_B12) 2003; 17
Allard ( key 20171012092311_B19) 1999; 18
Sun ( key 20171012092311_B40) 2009; 23
Dombecki ( key 20171012092311_B27) 2011; 21
Lee ( key 20171012092311_B42) 2008; 4
Saleh ( key 20171012092311_B50) 2008; 423
Conrad ( key 20171012092311_B31) 2012; 22
Luco ( key 20171012092311_B5) 2010; 327
Kobayashi ( key 20171012092311_B45) 1999; 286
Bertram ( key 20171012092311_B8) 2001; 266
Zhao ( key 20171012092311_B37) 2005; 7
Yuan ( key 20171012092311_B52) 2011; 286
Strahl ( key 20171012092311_B36) 2002; 22
Li ( key 20171012092311_B61) 2007; 316
Gu ( key 20171012092311_B60) 2013; 11
Nakayama ( key 20171012092311_B22) 2003; 22
Gelbart ( key 20171012092311_B62) 2009; 16
Jiang ( key 20171012092311_B56) 2008; 3
Lusser ( key 20171012092311_B28) 2001; 6
Reid ( key 20171012092311_B21) 2004; 24
Sun ( key 20171012092311_B14) 2008; 283
Bell ( key 20171012092311_B47) 2007; 26
Koos ( key 20171012092311_B46) 2014; 377
Xu ( key 20171012092311_B53) 2008; 28
Reid ( key 20171012092311_B24) 2000; 6
Roudier ( key 20171012092311_B6) 2011; 30
Cazzonelli ( key 20171012092311_B59) 2009; 21
Morales ( key 20171012092311_B64) 2005; 25
Joshi ( key 20171012092311_B3) 2005; 20
References_xml – volume: 323
  start-page: 173
  year: 2006
  ident: key 20171012092311_B44
  article-title: Cytogenetic analyses of Arabidopsis
  publication-title: Methods Mol. Biol.
  contributor:
    fullname: Lysak
– volume: 21
  start-page: 1092
  year: 2011
  ident: key 20171012092311_B27
  article-title: The chromodomain protein MRG-1 facilitates SC-independent homologous pairing during meiosis in Caenorhabditis elegans
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2011.09.019
  contributor:
    fullname: Dombecki
– volume: 276
  start-page: 3484
  year: 2001
  ident: key 20171012092311_B20
  article-title: The yeast NuA4 and Drosophila MSL complexes contain homologous subunits important for transcription regulation
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M008159200
  contributor:
    fullname: Eisen
– volume: 17
  start-page: 1240
  year: 2000
  ident: key 20171012092311_B7
  article-title: Origin and evolution of the regulatory gene male-specific lethal-3
  publication-title: Mol. Biol. Evol.
  doi: 10.1093/oxfordjournals.molbev.a026407
  contributor:
    fullname: Marin
– volume: 17
  start-page: 1870
  year: 2003
  ident: key 20171012092311_B13
  article-title: Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains
  publication-title: Genes Dev.
  doi: 10.1101/gad.1110503
  contributor:
    fullname: Fischle
– volume: 1
  start-page: 2019
  year: 2006
  ident: key 20171012092311_B43
  article-title: Rapid, transient expression of fluorescent fusion proteins in tobacco plants and generation of stably transformed plants
  publication-title: Nat. Protocol.
  doi: 10.1038/nprot.2006.286
  contributor:
    fullname: Sparkes
– volume: 283
  start-page: 36504
  year: 2008
  ident: key 20171012092311_B14
  article-title: Molecular basis of the interaction of Saccharomyces cerevisiae Eaf3 chromo domain with methylated H3K36
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M806564200
  contributor:
    fullname: Sun
– volume: 6
  start-page: 59
  year: 2001
  ident: key 20171012092311_B28
  article-title: Histone acetylation: lessons from the plant kingdom
  publication-title: Trends Plant Sci.
  doi: 10.1016/S1360-1385(00)01839-2
  contributor:
    fullname: Lusser
– volume: 26
  start-page: 4974
  year: 2007
  ident: key 20171012092311_B47
  article-title: Localized H3K36 methylation states define histone H4K16 acetylation during transcriptional elongation in Drosophila
  publication-title: EMBO J.
  doi: 10.1038/sj.emboj.7601926
  contributor:
    fullname: Bell
– volume: 138
  start-page: 1019
  year: 2009
  ident: key 20171012092311_B63
  article-title: Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes
  publication-title: Cell
  doi: 10.1016/j.cell.2009.06.049
  contributor:
    fullname: Wang
– volume: 451
  start-page: 734
  year: 2008
  ident: key 20171012092311_B23
  article-title: Cell cycle control of centromeric repeat transcription and heterochromatin assembly
  publication-title: Nature
  doi: 10.1038/nature06561
  contributor:
    fullname: Chen
– volume: 316
  start-page: 1050
  year: 2007
  ident: key 20171012092311_B61
  article-title: Combined action of PHD and chromo domains directs the Rpd3S HDAC to transcribed chromatin
  publication-title: Science
  doi: 10.1126/science.1139004
  contributor:
    fullname: Li
– volume: 28
  start-page: 1348
  year: 2008
  ident: key 20171012092311_B53
  article-title: Di- and tri- but not monomethylation on histone H3 lysine 36 marks active transcription of genes involved in flowering time regulation and other processes in Arabidopsis thaliana
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.01607-07
  contributor:
    fullname: Xu
– volume: 16
  start-page: 825
  year: 2009
  ident: key 20171012092311_B62
  article-title: Drosophila MSL complex globally acetylates H4K16 on the male X chromosome for dosage compensation
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/nsmb.1644
  contributor:
    fullname: Gelbart
– volume: 52
  start-page: 615
  year: 2007
  ident: key 20171012092311_B33
  article-title: In vitro specificities of Arabidopsis co-activator histone acetyltransferases: implications for histone hyperacetylation in gene activation
  publication-title: Plant J.
  doi: 10.1111/j.1365-313X.2007.03264.x
  contributor:
    fullname: Earley
– volume: 23
  start-page: 345
  year: 2013
  ident: key 20171012092311_B41
  article-title: A matrix protein silences transposons and repeats through interaction with retinoblastoma-associated proteins
  publication-title: Curr. Biol.
  doi: 10.1016/j.cub.2013.01.030
  contributor:
    fullname: Xu
– volume: 4
  start-page: e1000077
  year: 2008
  ident: key 20171012092311_B57
  article-title: Genic and global functions for Paf1C in chromatin modification and gene expression in Arabidopsis
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.1000077
  contributor:
    fullname: Oh
– volume: 30
  start-page: 1928
  year: 2011
  ident: key 20171012092311_B6
  article-title: Integrative epigenomic mapping defines four main chromatin states in Arabidopsis
  publication-title: EMBO J.
  doi: 10.1038/emboj.2011.103
  contributor:
    fullname: Roudier
– volume: 22
  start-page: 610
  year: 2012
  ident: key 20171012092311_B31
  article-title: The MOF chromobarrel domain controls genome-wide H4K16 acetylation and spreading of the MSL complex
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2011.12.016
  contributor:
    fullname: Conrad
– volume: 19
  start-page: 1266
  year: 2012
  ident: key 20171012092311_B48
  article-title: Molecular basis for H3K36me3 recognition by the Tudor domain of PHF1
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/nsmb.2435
  contributor:
    fullname: Musselman
– volume: 17
  start-page: 556
  year: 2012
  ident: key 20171012092311_B35
  article-title: Chromatin regulation of flowering
  publication-title: Trends Plant Sci.
  doi: 10.1016/j.tplants.2012.05.001
  contributor:
    fullname: He
– volume: 6
  start-page: 1297
  year: 2000
  ident: key 20171012092311_B24
  article-title: Coordinate regulation of yeast ribosomal protein genes is associated with targeted recruitment of Esa1 histone acetylase
  publication-title: Mol. Cell
  doi: 10.1016/S1097-2765(00)00128-3
  contributor:
    fullname: Reid
– volume: 11
  start-page: e1001649
  year: 2013
  ident: key 20171012092311_B60
  article-title: Photoperiodic regulation of flowering time through periodic histone deacetylation of the florigen gene FT
  publication-title: PLoS Biol.
  doi: 10.1371/journal.pbio.1001649
  contributor:
    fullname: Gu
– volume: 416
  start-page: 103
  year: 2002
  ident: key 20171012092311_B11
  article-title: Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9
  publication-title: Nature
  doi: 10.1038/nature722
  contributor:
    fullname: Nielsen
– volume: 34
  start-page: 6621
  year: 2006
  ident: key 20171012092311_B16
  article-title: Structure of human MRG15 chromo domain and its binding to Lys36-methylated histone H3
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkl989
  contributor:
    fullname: Zhang
– volume: 408
  start-page: 495
  year: 2000
  ident: key 20171012092311_B25
  article-title: Global histone acetylation and deacetylation in yeast
  publication-title: Nature
  doi: 10.1038/35044127
  contributor:
    fullname: Vogelauer
– volume: 377
  start-page: 111
  year: 2014
  ident: key 20171012092311_B46
  article-title: Analysis of protein interactions in situ by proximity ligation assays
  publication-title: Curr. Top. Microbiol. Immunol.
  contributor:
    fullname: Koos
– volume: 266
  start-page: 111
  year: 2001
  ident: key 20171012092311_B8
  article-title: Conservation of the MORF4 related gene family: identification of a new chromo domain subfamily and novel protein motif
  publication-title: Gene
  doi: 10.1016/S0378-1119(01)00372-9
  contributor:
    fullname: Bertram
– volume: 6
  start-page: e1001137
  year: 2010
  ident: key 20171012092311_B54
  article-title: Autoimmunity in Arabidopsis acd11 is mediated by epigenetic regulation of an immune receptor
  publication-title: PLoS Pathog.
  doi: 10.1371/journal.ppat.1001137
  contributor:
    fullname: Palma
– volume: 18
  start-page: 5108
  year: 1999
  ident: key 20171012092311_B19
  article-title: NuA4, an essential transcription adaptor/histone H4 acetyltransferase complex containing Esa1p and the ATM-related cofactor Tra1p
  publication-title: EMBO J.
  doi: 10.1093/emboj/18.18.5108
  contributor:
    fullname: Allard
– volume: 170
  start-page: 444
  year: 2013
  ident: key 20171012092311_B34
  article-title: Requirement of histone acetyltransferases HAM1 and HAM2 for epigenetic modification of FLC in regulating flowering in Arabidopsis
  publication-title: J. Plant Physiol.
  doi: 10.1016/j.jplph.2012.11.007
  contributor:
    fullname: Xiao
– volume: 4
  start-page: e7817
  year: 2009
  ident: key 20171012092311_B38
  article-title: The ASH1 HOMOLOG 2 (ASHH2) histone H3 methyltransferase is required for ovule and anther development in Arabidopsis
  publication-title: PloS One
  doi: 10.1371/journal.pone.0007817
  contributor:
    fullname: Grini
– volume: 410
  start-page: 1116
  year: 2001
  ident: key 20171012092311_B55
  article-title: CONSTANS mediates between the circadian clock and the control of flowering in Arabidopsis
  publication-title: Nature
  doi: 10.1038/35074138
  contributor:
    fullname: Suarez-Lopez
– volume: 21
  start-page: 39
  year: 2009
  ident: key 20171012092311_B59
  article-title: Regulation of carotenoid composition and shoot branching in Arabidopsis by a chromatin modifying histone methyltransferase, SDG8
  publication-title: Plant Cell
  doi: 10.1105/tpc.108.063131
  contributor:
    fullname: Cazzonelli
– volume: 16
  start-page: 1740
  year: 2008
  ident: key 20171012092311_B15
  article-title: Structural basis for the recognition of methylated histone H3K36 by the Eaf3 subunit of histone deacetylase complex Rpd3S
  publication-title: Structure
  doi: 10.1016/j.str.2008.08.008
  contributor:
    fullname: Xu
– volume: 17
  start-page: 1415
  year: 2003
  ident: key 20171012092311_B26
  article-title: Yeast enhancer of polycomb defines global Esa1-dependent acetylation of chromatin
  publication-title: Genes Dev.
  doi: 10.1101/gad.1056603
  contributor:
    fullname: Boudreault
– volume: 4
  start-page: 24
  year: 2008
  ident: key 20171012092311_B42
  article-title: Vectors for multi-color bimolecular fluorescence complementation to investigate protein-protein interactions in living plant cells
  publication-title: Plant Methods
  doi: 10.1186/1746-4811-4-24
  contributor:
    fullname: Lee
– volume: 17
  start-page: 617
  year: 2010
  ident: key 20171012092311_B49
  article-title: Molecular basis of histone H3K36me3 recognition by the PWWP domain of Brpf1
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/nsmb.1797
  contributor:
    fullname: Vezzoli
– volume: 42
  start-page: 330
  year: 2011
  ident: key 20171012092311_B51
  article-title: Histone methylation by PRC2 is inhibited by active chromatin marks
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2011.03.025
  contributor:
    fullname: Schmitges
– volume: 447
  start-page: 407
  year: 2007
  ident: key 20171012092311_B9
  article-title: The complex language of chromatin regulation during transcription
  publication-title: Nature
  doi: 10.1038/nature05915
  contributor:
    fullname: Berger
– volume: 19
  start-page: 321
  year: 2003
  ident: key 20171012092311_B29
  article-title: The diverse functions of histone acetyltransferase complexes
  publication-title: Trends Genet.
  doi: 10.1016/S0168-9525(03)00115-X
  contributor:
    fullname: Carrozza
– volume: 25
  start-page: 5947
  year: 2005
  ident: key 20171012092311_B64
  article-title: The MRG domain mediates the functional integration of MSL3 into the dosage compensation complex
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.25.14.5947-5954.2005
  contributor:
    fullname: Morales
– volume: 286
  start-page: 7983
  year: 2011
  ident: key 20171012092311_B52
  article-title: H3K36 methylation antagonizes PRC2-mediated H3K27 methylation
  publication-title: The Journal of biological chemistry
  doi: 10.1074/jbc.M110.194027
  contributor:
    fullname: Yuan
– volume: 22
  start-page: 2776
  year: 2003
  ident: key 20171012092311_B22
  article-title: Alp13, an MRG family protein, is a component of fission yeast Clr6 histone deacetylase required for genomic integrity
  publication-title: EMBO J.
  doi: 10.1093/emboj/cdg248
  contributor:
    fullname: Nakayama
– volume: 277
  start-page: 50860
  year: 2002
  ident: key 20171012092311_B18
  article-title: MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M203839200
  contributor:
    fullname: Pardo
– volume: 3
  start-page: e3404
  year: 2008
  ident: key 20171012092311_B56
  article-title: Repression of FLOWERING LOCUS C and FLOWERING LOCUS T by the Arabidopsis Polycomb repressive complex 2 components
  publication-title: PloS One
  doi: 10.1371/journal.pone.0003404
  contributor:
    fullname: Jiang
– volume: 20
  start-page: 971
  year: 2005
  ident: key 20171012092311_B3
  article-title: Eaf3 chromodomain interaction with methylated H3-K36 links histone deacetylation to Pol II elongation
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2005.11.021
  contributor:
    fullname: Joshi
– volume: 22
  start-page: 1298
  year: 2002
  ident: key 20171012092311_B36
  article-title: Set2 is a nucleosomal histone H3-selective methyltransferase that mediates transcriptional repression
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.22.5.1298-1306.2002
  contributor:
    fullname: Strahl
– volume: 286
  start-page: 1960
  year: 1999
  ident: key 20171012092311_B45
  article-title: A pair of related genes with antagonistic roles in mediating flowering signals
  publication-title: Science
  doi: 10.1126/science.286.5446.1960
  contributor:
    fullname: Kobayashi
– volume: 17
  start-page: 1823
  year: 2003
  ident: key 20171012092311_B12
  article-title: Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27
  publication-title: Genes Dev.
  doi: 10.1101/gad.269603
  contributor:
    fullname: Min
– volume: 8
  start-page: 121
  year: 2008
  ident: key 20171012092311_B32
  article-title: The MYST histone acetyltransferases are essential for gametophyte development in Arabidopsis
  publication-title: BMC Plant Biol.
  doi: 10.1186/1471-2229-8-121
  contributor:
    fullname: Latrasse
– volume: 3
  start-page: 174
  year: 2010
  ident: key 20171012092311_B58
  article-title: Transcriptional control of SET DOMAIN GROUP 8 and CAROTENOID ISOMERASE during Arabidopsis development
  publication-title: Mol. Plant
  doi: 10.1093/mp/ssp092
  contributor:
    fullname: Cazzonelli
– volume: 327
  start-page: 996
  year: 2010
  ident: key 20171012092311_B5
  article-title: Regulation of alternative splicing by histone modifications
  publication-title: Science
  doi: 10.1126/science.1184208
  contributor:
    fullname: Luco
– volume: 123
  start-page: 581
  year: 2005
  ident: key 20171012092311_B2
  article-title: Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription
  publication-title: Cell
  doi: 10.1016/j.cell.2005.10.023
  contributor:
    fullname: Carrozza
– volume: 20
  start-page: 312
  year: 2000
  ident: key 20171012092311_B30
  article-title: The drosophila MSL complex acetylates histone H4 at lysine 16, a chromatin modification linked to dosage compensation
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.20.1.312-318.2000
  contributor:
    fullname: Smith
– volume: 423
  start-page: 43
  year: 2008
  ident: key 20171012092311_B50
  article-title: Dynamic and stable histone H3 methylation patterns at the Arabidopsis FLC and AP1 loci
  publication-title: Gene
  doi: 10.1016/j.gene.2008.06.022
  contributor:
    fullname: Saleh
– volume: 7
  start-page: 1256
  year: 2005
  ident: key 20171012092311_B37
  article-title: Prevention of early flowering by expression of FLOWERING LOCUS C requires methylation of histone H3 K36
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb1329
  contributor:
    fullname: Zhao
– volume: 123
  start-page: 593
  year: 2005
  ident: key 20171012092311_B4
  article-title: Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex
  publication-title: Cell
  doi: 10.1016/j.cell.2005.10.025
  contributor:
    fullname: Keogh
– volume: 41
  start-page: 376
  year: 2009
  ident: key 20171012092311_B1
  article-title: Differential chromatin marking of introns and expressed exons by H3K36me3
  publication-title: Nat. Genet.
  doi: 10.1038/ng.322
  contributor:
    fullname: Kolasinska-Zwierz
– volume: 276
  start-page: 39171
  year: 2001
  ident: key 20171012092311_B17
  article-title: MRG15 activates the B-myb promoter through formation of a nuclear complex with the retinoblastoma protein and the novel protein PAM14
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M103435200
  contributor:
    fullname: Leung
– volume: 23
  start-page: 1791
  year: 2009
  ident: key 20171012092311_B40
  article-title: A timing mechanism for stem cell maintenance and differentiation in the Arabidopsis floral meristem
  publication-title: Genes Dev.
  doi: 10.1101/gad.1800409
  contributor:
    fullname: Sun
– volume: 28
  start-page: 3401
  year: 2008
  ident: key 20171012092311_B65
  article-title: Transcription-coupled methylation of histone H3 at lysine 36 regulates dosage compensation by enhancing recruitment of the MSL complex in Drosophila melanogaster
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.00006-08
  contributor:
    fullname: Bell
– volume: 24
  start-page: 757
  year: 2004
  ident: key 20171012092311_B21
  article-title: Eaf3 regulates the global pattern of histone acetylation in Saccharomyces cerevisiae
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.24.2.757-764.2004
  contributor:
    fullname: Reid
– volume: 139
  start-page: 5
  year: 2005
  ident: key 20171012092311_B39
  article-title: Genome-wide identification and testing of superior reference genes for transcript normalization in Arabidopsis
  publication-title: Plant Physiol.
  doi: 10.1104/pp.105.063743
  contributor:
    fullname: Czechowski
– volume: 295
  start-page: 2080
  year: 2002
  ident: key 20171012092311_B10
  article-title: Structure of HP1 chromodomain bound to a lysine 9-methylated histone H3 tail
  publication-title: Science
  doi: 10.1126/science.1069473
  contributor:
    fullname: Jacobs
SSID ssj0014154
Score 2.4294565
Snippet Trimethylation of lysine 36 of histone H3 (H3K36me3) is found to be associated with various transcription events. In Arabidopsis, the H3K36me3 level peaks in...
Trimethylation of lysine 36 of histone H3 (H3K36me3) is found to be associated with various transcription events. In Arabidopsis , the H3K36me3 level peaks in...
SourceID pubmedcentral
proquest
crossref
pubmed
SourceType Open Access Repository
Aggregation Database
Index Database
StartPage 10960
SubjectTerms Acetylation
Arabidopsis - genetics
Arabidopsis - growth & development
Arabidopsis Proteins - analysis
Arabidopsis Proteins - genetics
Arabidopsis Proteins - metabolism
Chromosomal Proteins, Non-Histone - analysis
Chromosomal Proteins, Non-Histone - genetics
Chromosomal Proteins, Non-Histone - metabolism
Euchromatin - chemistry
Flowers - genetics
Gene Expression Regulation, Plant
Gene regulation, Chromatin and Epigenetics
Histone Acetyltransferases - metabolism
Histone-Lysine N-Methyltransferase - metabolism
Histones - metabolism
MADS Domain Proteins - genetics
MADS Domain Proteins - metabolism
Mutation
Phenotype
Transcription, Genetic
Title Arabidopsis MRG domain proteins bridge two histone modifications to elevate expression of flowering genes
URI https://www.ncbi.nlm.nih.gov/pubmed/25183522
https://search.proquest.com/docview/1566112384
https://pubmed.ncbi.nlm.nih.gov/PMC4176166
Volume 42
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB61vcAFlZbH8qgGgbil6SZOHB9XK0pVaQGhVtpb5FdKROOsdrMq_HvGTlKxcOsllySWNWN5vrG_-Qbgg-LakmunkWSyihjtwpFMMhOdaVEJkVGWHcqjF1_yi2t2ucyWe5CNtTCBtK9Vfepum1NX_wjcylWj45EnFn9bzNmUku88j_dhn8LvmKIPVwcUkXrNqCCxyYpRk1SksZPr-Obnlhe-PwwF9oA-dgPSfyjzX7LkX9Hn_BCeDLARZ_30nsKedUdwPHOUMje_8SMGImc4IT-CR_Oxidsx1LO1VLVpV5t6g4vvn9G0jawdBnmG2m2wL9jC7q7FID3sLDat8fyh_igPuxZ9CTpBUrS_Btasw7bC6tY3WKPIhzd-v3wG1-efruYX0dBdIdKMsS4iKyiZMn6WG5EKpawkrJcUqkgrj6mY5Saj3ERkhhPkY5pzm6eWZ1qqRBtKbZ_DgaNZvQSUMk-UYIagRsG0koJPp5Wo_MFAENibwPvRxOWqF9Eo-8vvtCSflL1PJvButH5JVvIXF9LZdrspfY5JuJAGn8CL3hv344xunADf8dP9B14_e_cNLaugoz0so1cP_vM1PCb8xDx9JBFv4KBbb-1bwiidOgm5_UlYmfS8-rr8A0vY660
link.rule.ids 230,314,727,780,784,864,885,27924,27925,53791,53793
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1NT9wwEB1RONBL1UJbtrTFVaveQkjixPFxtSosLYuqCiRukb8CEcRZ7WZF--87dhLULTfOcSxrxvK8sd-8AfgimTLo2igQVJQBxVM4EHGqgyPFS85TzLJ9efTsPJte0u9X6dUGpEMtjCftK1kd2rv60FY3nls5r1U48MTCn7MJjTD5zrLwGWylCePRkKT3jwcYkzrVKC-ySfNBlZQnoRWL8Pp2xXLXIQZDu8cf6yHpEc78ny75T_w5fgkveuBIxt0CX8GGsTuwO7aYNNd_yFfiqZz-jnwHtidDG7ddqMYLISvdzJfVksx-nRDd1KKyxAs0VHZJupIt0t43xIsPW0PqRjsGUXeZR9qGuCJ0BKXE_O55s5Y0JSnvXIs1jH3k2p2Yr-Hy-NvFZBr0_RUCRSltA7SCFAllR5nmCZfSCER7cS7zpHSoihqmU8xOeKoZgj6qGDNZYliqhIyVxuT2DWxaXNUeECGyWHKqEWzkVEnBWRSVvHRXA15ibwSfBxMX805Go-iev5MCfVJ0PhnBp8H6BVrJPV0Ia5rVsnBZJiJDnHwEbztvPMwzuHEEbM1PDwOcgvb6F9xYXkm730jvnvznAWxPL2Znxdnp-Y99eI5oijoySczfw2a7WJkPiFha-dHvz7-8J-zx
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1NT9wwEB1RkFouqEALS6F11aq3EDZx4vi42rLQj0WoKhK3yF-hUYmz2s0K-u8ZOwli21vPcSxrZuR5Yz-_AfgomTLo2mEgqCgCirtwIKJEByeKF5wnWGX759HTi_T8in69Tq6ftPrypH0ly2N7Wx3b8pfnVs4qFfY8sfByOqZDLL7TNJzpInwGG0mMQdYX6t0FAualVjnKC23SrFcm5XFoxTy8-b1kmesSg-ndY5DVtPQP1vybMvkkB01ewlYHHsmoXeQ2rBm7A7sji4Vz9Yd8Ip7O6c_Jd-DFuG_ltgvlaC5kqevZolyQ6Y8zoutKlJZ4kYbSLkj7bIs0dzXxAsTWkKrWjkXUHuiRpibuIToCU2LuO-6sJXVBilvXZg3zH7lxu-YruJqc_hyfB12PhUBRSpsArSBFTNlJqnnMpTQCEV-UySwuHLKihukEKxSeaIbAjyrGTBoblighI6WxwH0N6xZXtQ9EiDSSnGoEHBlVUnA2HBa8cMcDXmZvAB96E-ezVkojb6_A4xx9krc-GcD73vo5WsldXwhr6uUid5UmokOcfAB7rTce5-ndOAC24qfHAU5Fe_ULBpdX0-6C6eC__3wHzy8_T_LvXy6-vYFNBFTU8UkifgjrzXxpjhC0NPKtD88HIEnuBA
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Arabidopsis+MRG+domain+proteins+bridge+two+histone+modifications+to+elevate+expression+of+flowering+genes&rft.jtitle=Nucleic+acids+research&rft.au=Xu%2C+Yifeng&rft.au=Gan%2C+Eng-Seng&rft.au=Zhou%2C+Jie&rft.au=Wee%2C+Wan-Yi&rft.date=2014-09-29&rft.eissn=1362-4962&rft.volume=42&rft.issue=17&rft.spage=10960&rft_id=info:doi/10.1093%2Fnar%2Fgku781&rft_id=info%3Apmid%2F25183522&rft.externalDocID=25183522
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0305-1048&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0305-1048&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0305-1048&client=summon