Activation of a Frizzled-2/β -adrenergic Receptor Chimera Promotes Wnt Signaling and Differentiation of Mouse F9 Teratocarcinoma Cells via Gα o and Gα t

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 96; no. 25; pp. 14383 - 14388
• Main Authors: Liu, Xunxian, Liu, Tong, Slusarski, Diane C., Yang-Snyder, Julia, Malbon, Craig C., Moon, Randall T., Wang, Hsien-Yu
• Format: Journal Article
• Language: English
• Published: National Academy of Sciences of the United States of America 07.12.1999; National Acad Sciences; The National Academy of Sciences
• Subjects: b-adrenergic receptors; Biological Sciences; Calcium; Chimeras; CHO cells; Embryos; frizzled gene; frizzled-2 gene; Natural satellites; pertussis toxin; Protein subunits; Receptors; RNA; tetracarcinoma; Toxins; Whooping cough; Wnt gene

The frizzled gene family of putative Wnt receptors encodes proteins that have a seven-transmembrane-spanning motif characteristic of G protein-linked receptors, though no loss-of-function studies have demonstrated a requirement for G proteins for Frizzled signaling. We engineered a Frizzled-2 chimer...