Biphasic MIF and SDF1 expression during podocyte injury promote CD44-mediated glomerular parietal cell migration in focal segmental glomerulosclerosis

• Published in: American journal of physiology. Regulatory, integrative and comparative physiology Vol. 318; no. 3; pp. F741 - F753
• Main Authors: Ito, Naoko, Sakamoto, Kazuo, Hikichi, Chihiro, Matsusaka, Taiji, Nagata, Michio
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.03.2020
• Subjects: CD44 antigen; Cell activation; Cell adhesion & migration; Cell migration; Chemokines; Crosstalk; CXCR4 protein; Epithelial cells; Injuries; Kinases; Macrophage migration inhibitory factor; mRNA; Parietal cells; Proteinuria; SDF-1 protein; Signal transduction; Signaling; siRNA; Toxins; chemokine; migration inhibitory factor; podocyte injury; migration; parietal epithelial cells; CD44; stromal cell-derived factor 1

Glomerular parietal epithelial cell (PEC) activation, as revealed by de novo expression of CD44 and cell migration toward the injured filtration barrier, is a hallmark of podocyte injury-driven focal segmental glomerulosclerosis (FSGS). However, the signaling pathway that mediates activation of PECs...