Toll-like Receptor and Hepatitis B Virus Clearance in Chronic Infected Patients: A Long-Term Prospective Cohort Study in Taiwan

• Published in: The Journal of infectious diseases Vol. 206; no. 5; pp. 662 - 668
• Main Authors: Wu, Jia-Feng, Chen, Chien-Hung, Ni, Yen-Hsuan, Lin, Ying-Ting, Chen, Huey-Ling, Hsu, Hong-Yuan, Chang, Mei-Hwei
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.09.2012
• Subjects: Alleles; Biological and medical sciences; Child; Chronic hepatitis; Cohort Studies; DNA - chemistry; DNA - genetics; Female; Fundamental and applied biological sciences. Psychology; Genetic Variation; Genotype; Genotypes; Hepatitis antigens; Hepatitis B; Hepatitis B Core Antigens - blood; Hepatitis B e Antigens - blood; Hepatitis B Surface Antigens - blood; Hepatitis B virus; Hepatitis B virus - genetics; Hepatitis B virus - isolation & purification; Hepatitis B, Chronic - blood; Hepatitis B, Chronic - virology; Humans; Infections; Infectious diseases; Logistic Models; Male; Medical sciences; Microbiology; Miscellaneous; P values; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Prospective Studies; Radioimmunoassay; Referents; Taiwan; Toll like receptors; Toll-Like Receptors - biosynthesis; Toll-Like Receptors - genetics; Viral Load; Virology; VIRUSES; Asia; Taiwan; Far east; Virus; Human; Infection; Subtropical zone; Chronic; Hepadnaviridae; Cohort study; Orthohepadnavirus; Toll like receptor; Hepatitis B virus

Background. We sought to elucidate the impacts of the Toll-like receptors (TLRs) on spontaneous hepatitis B virus (HBV) e antigen (HBeAg) and hepatitis B s antigen (HBsAg) seroconversion in chronic HBV-infected patients. Methods. Human TLR2, TLR4, TLR5y and TLR9 gene polymorphisms were assessed in 2...