Syndecan-4 signaling at a glance

• Published in: Journal of cell science Vol. 126; no. Pt 17; pp. 3799 - 3804
• Main Authors: Elfenbein, Arye, Simons, Michael
• Format: Journal Article
• Language: English
• Published: England The Company of Biologists 01.09.2013
• Subjects: Cell Membrane - metabolism; Cell Movement; Cell Proliferation; Cell Science at a Glance; Endocytosis; Fibroblast Growth Factors - metabolism; Humans; Mechanotransduction, Cellular; Platelet-Derived Growth Factor - metabolism; Proto-Oncogene Proteins c-akt - metabolism; rho GTP-Binding Proteins - metabolism; Signal Transduction; Syndecan-4 - metabolism; TOR Serine-Threonine Kinases - metabolism; Vascular Endothelial Growth Factor A - metabolism

Syndecan-4, a ubiquitous cell surface proteoglycan, mediates numerous cellular processes through signaling pathways that affect cellular proliferation, migration, mechanotransduction and endocytosis. These effects are achieved through syndecan-4 functioning as both a co-receptor for the fibroblast g...