Diffusion tensor imaging (DTI) and proton magnetic resonance spectroscopy ( 1H MRS) in schizophrenic subjects and normal controls

• Published in: Psychiatry research Vol. 106; no. 3; pp. 161 - 170
• Main Authors: Steel, Robby M., Bastin, Mark E., McConnell, Sarah, Marshall, Ian, Cunningham-Owens, David G., Lawrie, Stephen M., Johnstone, Eve C., Best, Jonathan J.K.
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 30.05.2001; Elsevier
• Subjects: Adult; Adult and adolescent clinical studies; Anisotropy; Aspartic Acid - analogs & derivatives; Aspartic Acid - metabolism; Biological and medical sciences; Brain - metabolism; Brain - physiopathology; Female; Frontal lobe; Functional Laterality - physiology; Humans; Magnetic resonance imaging; Magnetic Resonance Spectroscopy; Male; Medical sciences; Neurons; Neurons - metabolism; Prefrontal Cortex - metabolism; Prefrontal Cortex - physiopathology; Protons; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Schizophrenia; Schizophrenia - diagnosis; Schizophrenia - metabolism; Schizophrenia - physiopathology; Temporal Lobe - metabolism; Temporal Lobe - physiopathology; Schizophrenia; Frontal lobe; Magnetic resonance imaging; Neurons; Human; Acyltransferases; Hemispheric specialization; Aspartate N-acetyltransferase; Enzyme; Transferases; Central nervous system; NMR spectrometry; Metabolism; White matter; Psychosis; Neuron; Anisotropic scattering; Diffusion coefficient; Laterality; Comparative study; Brain (vertebrata)

Several proton magnetic resonance spectroscopy ( 1H MRS) studies in schizophrenia have found reduced N-acetyl aspartate (NAA) concentrations in pre-frontal and temporal regions of the brain. Reductions in NAA may reflect abnormalities of neuronal structure (e.g. reduced neuronal density or viability...