Simvastatin Attenuates Cardiac Fibrosis via Regulation of Cardiomyocyte-Derived Exosome Secretion

• Published in: Journal of clinical medicine Vol. 8; no. 6; p. 794
• Main Authors: Kuo, Hsuan-Fu, Hsieh, Chong-Chao, Wang, Shu-Chi, Chang, Chia-Yuan, Hung, Chih-Hsin, Kuo, Po-Lin, Liu, Yu-Ru, Li, Chia-Yang, Liu, Po-Len
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 04.06.2019
• Subjects: cardiac fibrosis; decorin; periostin; exosomes; statins

Exosome-mediated communication within the cardiac microenvironment is associated with cardiac fibrosis. Simvastatin (SIM), a potent statin, protects against cardiac fibrosis, but its mechanism of action is unclear. We investigated the inhibitory effects and underlying mechanism of simvastatin in car...