Cell-type deconvolution from DNA methylation: a review of recent applications

• Published in: Human molecular genetics Vol. 26; no. R2; pp. R216 - R224
• Main Authors: Titus, Alexander J, Gallimore, Rachel M, Salas, Lucas A, Christensen, Brock C
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.10.2017
• Subjects: Algorithms; Animals; Computational Biology - methods; Computer Simulation; DNA Methylation - genetics; DNA Methylation - physiology; Genome-Wide Association Study; Humans; Invited Reviews; Sequence Analysis, DNA - methods

Recent advances in cell-type deconvolution approaches are adding to our understanding of the biology underlying disease development and progression. DNA methylation (DNAm) can be used as a biomarker of cell types, and through deconvolution approaches, to infer underlying cell type proportions. Cell-...