Sex differences in renin-angiotensin-aldosterone system affect extracellular volume in healthy subjects

• Published in: American journal of physiology. Renal physiology Vol. 314; no. 5; pp. F873 - F878
• Main Authors: Toering, Tsjitske J., Gant, Christina M., Visser, Folkert W., van der Graaf, Anne Marijn, Laverman, Gozewijn D., Danser, A. H. Jan, Faas, Marijke M., Navis, Gerjan, Lely, A. Titia
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.05.2018
• Subjects: Adrenal Glands - drug effects; Adrenal Glands - metabolism; Adult; Aldosterone; Aldosterone - blood; Angiotensin; Angiotensin II; Angiotensin II - administration & dosage; Blood Pressure; Body Water - metabolism; Cross-Over Studies; Diet, Sodium-Restricted; Female; Fluid Shifts; Gender differences; Healthy Volunteers; Hormones; Humans; Infusions, Intravenous; Male; Menopause; Random Allocation; Renin; Renin-Angiotensin System; Sex differences; Sex Factors; Sodium; Sodium, Dietary - administration & dosage; Sodium, Dietary - metabolism; Water-Electrolyte Balance; Young Adult; aldosterone; extracellular volume; renin-angiotensin system; healthy volunteers; sex
• ISSN: 1931-857X; 1522-1466; 1522-1466
• DOI: 10.1152/ajprenal.00109.2017

Several studies reported sex differences in aldosterone. It is unknown whether these differences are associated with differences in volume regulation. Therefore we studied both aldosterone and extracellular volume in men and women on different sodium intakes. In healthy normotensive men ( n = 18) an...