Complex sex-biased antibody responses: estrogen receptors bind estrogen response elements centered within immunoglobulin heavy chain gene enhancers

• Published in: International immunology Vol. 31; no. 3; pp. 141 - 156
• Main Authors: Jones, Bart G, Sealy, Robert E, Penkert, Rhiannon R, Surman, Sherri L, Maul, Robert W, Neale, Geoff, Xu, Beisi, Gearhart, Patricia J, Hurwitz, Julia L
• Format: Journal Article
• Language: English
• Published: UK Oxford University Press 05.03.2019
• Subjects: Animals; Antibody Formation - genetics; Antibody Formation - immunology; Binding Sites; Enhancer Elements, Genetic; Immunoglobulin Heavy Chains - genetics; Immunoglobulin Heavy Chains - immunology; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Original Research; Receptors, Estrogen - metabolism; Response Elements - genetics; Response Elements - immunology; Sex Characteristics; vaccine; female; ligand; male; nuclear hormone receptor

Nuclear hormones influence antibody production quantitatively and qualitatively Abstract Nuclear hormone receptors including the estrogen receptor (ERα) and the retinoic acid receptor regulate a plethora of biological functions including reproduction, circulation and immunity. To understand how estr...