Drug-Induced Liver Injury during Consolidation Therapy in Childhood Acute Lymphoblastic Leukemia as Assessed for Causality Using the Updated RUCAM

• Published in: Canadian Journal of Gastroenterology and Hepatology Vol. 2022; pp. 1 - 9
• Main Authors: Qin, Fu-Li, Sang, Guo-You, Zou, Xiao-Qin, Cheng, Dao-Hai
• Format: Journal Article
• Language: English
• Published: Egypt Hindawi 2022; John Wiley & Sons, Inc; Wiley
• Subjects: Age; Aspartate Aminotransferases; Causality; Chemical and Drug Induced Liver Injury - epidemiology; Chemical and Drug Induced Liver Injury - etiology; Chemotherapy; Child; Child, Preschool; Childhood; Children & youth; Consolidation Chemotherapy; Drug dosages; Humans; Leukemia; Liver; Pediatrics; Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy; Statistical analysis

Purpose. The presence of serious toxicities is a major problem in the treatment of childhood acute lymphoblastic leukemia (ALL). The objective of this research is to evaluate drug-induced liver injury (DILI) during consolidation therapy in childhood ALL. Methods. Clinical data of pediatric patients...