Interferon-λ and interleukin 22 act synergistically for the induction of interferon-stimulated genes and control of rotavirus infection

• Published in: Nature immunology Vol. 16; no. 7; pp. 698 - 707
• Main Authors: Hernández, Pedro P, Mahlakõiv, Tanel, Yang, Ines, Schwierzeck, Vera, Nguyen, Nam, Guendel, Fabian, Gronke, Konrad, Ryffel, Bernhard, Hölscher, Christoph, Dumoutier, Laure, Renauld, Jean-Christophe, Suerbaum, Sebastian, Staeheli, Peter, Diefenbach, Andreas
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.07.2015; Nature Publishing Group
• Subjects: 13; 13/31; 14; 38; 631/250/127/1213; 631/250/2504/2506; 64; 64/60; Animals; Biomedicine; Caco-2 Cells; Cell Line; Chlorocebus aethiops; Cytokines - genetics; Cytokines - immunology; Cytokines - pharmacology; Development and progression; Dogs; Drug metabolism; Drug Synergism; Epithelial Cells - immunology; Epithelial Cells - metabolism; Epithelial Cells - virology; Gene Expression - drug effects; Gene Expression - immunology; Genetic aspects; HT29 Cells; Humans; Immune response; Immunoblotting; Immunology; Infectious Diseases; Interferon; Interleukin-22; Interleukins; Interleukins - genetics; Interleukins - immunology; Interleukins - pharmacology; Intestinal Mucosa - metabolism; Intestines - immunology; Intestines - virology; Madin Darby Canine Kidney Cells; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Molecular Sequence Data; Patient outcomes; Receptors, Cytokine - genetics; Receptors, Cytokine - immunology; Regulation; Reoviridae; Reverse Transcriptase Polymerase Chain Reaction; Rotavirus; Rotavirus infections; Rotavirus Infections - genetics; Rotavirus Infections - immunology; Rotavirus Infections - virology; STAT1 Transcription Factor - genetics; STAT1 Transcription Factor - immunology; STAT1 Transcription Factor - metabolism; Vero Cells

Epithelial surfaces are the main entry point for viruses and thus are important immunological sites. Diefenbach and colleagues show that the related cytokines IL-22 and IFN-λ act together in the control of enterovirus infection. The epithelium is the main entry point for many viruses, but the proces...